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Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 6/2014, Volume 391, Issue 1, pp. 127 - 136
Incense smoke is increasingly being recognized as a potential environmental contaminant and is linked to malignant and non-malignant respiratory diseases. The... 
Life Sciences | Biochemistry, general | Cytochrome p-450 | Oxidative stress | Lung | Liver | Incense | Medical Biochemistry | Oncology | Inflammation | Cardiology | PARTICLES | POLYCYCLIC AROMATIC-HYDROCARBONS | RISK | DNA ADDUCT FORMATION | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | ORGANIC EXTRACTS | CIGARETTE-SMOKE | AIR-POLLUTANTS | EXPRESSION | PARTICULATE MATTER | Tumor Necrosis Factor-alpha - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Inflammation - pathology | Liver - pathology | Liver - enzymology | Rats, Wistar | Cytochrome P-450 CYP1B1 - metabolism | Male | RNA, Messenger - metabolism | Cytochrome P-450 CYP1B1 - biosynthesis | Lung - enzymology | Organ Specificity - genetics | Cytochrome P-450 CYP1A2 - genetics | Biomarkers - metabolism | Lung - pathology | Smoke - adverse effects | Interleukin-4 - metabolism | RNA, Messenger - genetics | Oxidative Stress - genetics | Enzyme Induction | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Environmental Exposure - adverse effects | Animals | Cytochrome P-450 CYP1A2 - biosynthesis | Perfume - adverse effects | Cytochrome P-450 CYP1A1 - biosynthesis | Inflammation - enzymology | Metabolites | Polycyclic aromatic hydrocarbons | DNA | Cytochrome P-450 | Enzymes | Biochemistry | DNA damage | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Archives of Toxicology, ISSN 0340-5761, 2/2016, Volume 90, Issue 2, pp. 291 - 304
The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role... 
Benzo[ a ]pyrene | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Carcinogen metabolism | DNA adducts | Pharmacology/Toxicology | Tumour suppressor p53 | Biomedicine general | Benzo[a]pyrene | DNA-ADDUCTS | METABOLIC-ACTIVATION | HUMAN CANCER-CELLS | P53 | RESPONSES | ARISTOLOCHIC ACID I | MESSENGER-RNA | MICE | TOXICOLOGY | EXPRESSION | BENZO(A)PYRENE | DNA Damage - drug effects | Cell Survival - drug effects | Cytochrome P-450 CYP1B1 - genetics | Inactivation, Metabolic | Polycyclic Aromatic Hydrocarbons - pharmacokinetics | Benzo(a)pyrene - toxicity | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Tumor Suppressor Protein p53 - metabolism | Cytochrome P-450 CYP1B1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Cytochrome P-450 CYP1A1 - metabolism | HCT116 Cells - drug effects | Tumor Suppressor Protein p53 - genetics | Carcinogens - toxicity | DNA Adducts | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cytochrome P-450 Enzyme Inducers - poisoning | DNA Damage - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 Enzyme Inducers - pharmacology | Toxicity Tests | Cytochrome P-450 Enzyme Inducers - toxicity | Metabolites | Benzopyrene | Analysis | Cytochrome P-450 | Physiological aspects | Tumor proteins | Xenobiotics | Cells | Cytochrome | Carcinogens | Polycyclic aromatic hydrocarbons | Tumors | Index Medicus | Toxicokinetics and Metabolism
Journal Article
Journal Article
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 267 - 275
Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic hydrocarbons; therefore, its inhibition interferes with the carcinogenesis... 
Naringenin | CYP1A1 inhibitor | Dihydroxybergamottin | Molecular modeling | MOLECULAR-DYNAMICS | IN-VITRO INHIBITION | SIMVASTATIN METABOLISM | PARTICLE MESH EWALD | CYTOCHROMES P450 1A1 | O-DEETHYLATION | SUBSTRATE-BINDING | CARCINOGEN METABOLISM | TOXICOLOGY | HUMAN-LIVER-MICROSOMES | Cytochrome P-450 CYP1A1 - genetics | Rats, Wistar | Humans | Molecular Conformation | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Cytochrome P-450 Enzyme Inhibitors - metabolism | Anticarcinogenic Agents - metabolism | Flavanones - chemistry | Microsomes, Liver - drug effects | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Anticarcinogenic Agents - pharmacology | Furocoumarins - chemistry | Binding, Competitive | Recombinant Proteins - metabolism | Catalytic Domain | Furocoumarins - metabolism | Furocoumarins - pharmacology | Citrus paradisi - chemistry | Flavanones - pharmacology | Food-Drug Interactions | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A1 - chemistry | Molecular Dynamics Simulation | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Flavanones - metabolism | Fruit and Vegetable Juices - analysis | Ligands | Molecular Docking Simulation | Cytochrome P-450 | Fruit juices | Physiological aspects | Polycyclic aromatic hydrocarbons | Index Medicus | Enzymes | Carcinogens | Inhibitors | Computation | Grapefruit | Mathematical models | Juices | Inhibition
Journal Article