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Molecular and Cellular Biochemistry, ISSN 0300-8177, 6/2014, Volume 391, Issue 1, pp. 127 - 136
Incense smoke is increasingly being recognized as a potential environmental contaminant and is linked to malignant and non-malignant respiratory diseases. The... 
Life Sciences | Biochemistry, general | Cytochrome p-450 | Oxidative stress | Lung | Liver | Incense | Medical Biochemistry | Oncology | Inflammation | Cardiology | PARTICLES | POLYCYCLIC AROMATIC-HYDROCARBONS | RISK | DNA ADDUCT FORMATION | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | ORGANIC EXTRACTS | CIGARETTE-SMOKE | AIR-POLLUTANTS | EXPRESSION | PARTICULATE MATTER | Tumor Necrosis Factor-alpha - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Inflammation - pathology | Liver - pathology | Liver - enzymology | Rats, Wistar | Cytochrome P-450 CYP1B1 - metabolism | Male | RNA, Messenger - metabolism | Cytochrome P-450 CYP1B1 - biosynthesis | Lung - enzymology | Organ Specificity - genetics | Cytochrome P-450 CYP1A2 - genetics | Biomarkers - metabolism | Lung - pathology | Smoke - adverse effects | Interleukin-4 - metabolism | RNA, Messenger - genetics | Oxidative Stress - genetics | Enzyme Induction | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Environmental Exposure - adverse effects | Animals | Cytochrome P-450 CYP1A2 - biosynthesis | Perfume - adverse effects | Cytochrome P-450 CYP1A1 - biosynthesis | Inflammation - enzymology | Metabolites | Polycyclic aromatic hydrocarbons | DNA | Cytochrome P-450 | Enzymes | Biochemistry | DNA damage | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 27, pp. 11115 - 11120
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear. Here, we show that the... 
Bone resorption | Enzymes | Cell lines | Stem cells | Bones | Osteoclasts | Cultured cells | Bone marrow cells | Cigarette smoking | Aryl hydrocarbon receptors | Osteoblast | Skeletal remodeling | Toxicology | Bone formation | toxicology | TARGET | RESORPTION | MULTIDISCIPLINARY SCIENCES | osteoblast | AHR | skeletal remodeling | CANCER | IN-VITRO | INHIBITION | METABOLISM | bone formation | CIGARETTE-SMOKE | HEALTH | OSTEOCLAST DIFFERENTIATION | Smoking - adverse effects | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Aryl Hydrocarbon Hydroxylases - biosynthesis | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP1A2 - deficiency | Bone Resorption - metabolism | Female | Cytochrome P-450 CYP1A1 - deficiency | Disease Models, Animal | Bone Resorption - etiology | Benzo(a)pyrene - toxicity | Smoke - adverse effects | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Smoking - genetics | Receptors, Aryl Hydrocarbon - physiology | Tobacco - toxicity | Mice, Knockout | Enzyme Induction - genetics | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Cytochrome P-450 CYP1A2 - biosynthesis | Bone Resorption - pathology | Cytochrome P-450 CYP1B1 | Polychlorinated Dibenzodioxins - toxicity | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Osteoporosis | Carcinogens | Cocarcinogens | Hydrocarbons | Physiological aspects | Health aspects | Smoking | Genotype & phenotype | Rodents | Bone marrow | Toxins | Cells | Risk factors | Index Medicus | Biological Sciences
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 10/2012, Volume 120, Issue 10, pp. 1425 - 1431
Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult... 
Pregnancy | Statistical significance | Animal nesting | Cord blood | Tobacco smoking | Epigenetics | Methylation | Cigarette smoking | Cells | Children's Health | Blood plasma | Epigenome-wide | In utero | Maternal smoking | CHILD COHORT | epigenome-wide | in utero | GENE-REGULATION | epigenetics | SUPPLEMENTATION | WOMEN | ENVIRONMENTAL SCIENCES | CIGARETTE-SMOKING | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HUMAN GENOME | ARYL-HYDROCARBON RECEPTOR | methylation | NORWEGIAN MOTHER | TOBACCO-SMOKE | maternal smoking | EXPOSURE | Cytochrome P-450 CYP1A1 - genetics | United States - epidemiology | Prenatal Exposure Delayed Effects - epidemiology | Epigenesis, Genetic | Humans | Male | Maternal Exposure | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | DNA Methylation | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cotinine - blood | Chromatography, Liquid | Adult | Female | Infant, Newborn | Repressor Proteins - metabolism | Genome-Wide Association Study | Basic Helix-Loop-Helix Transcription Factors - genetics | Repressor Proteins - genetics | Biomarkers - blood | Transcription Factors - genetics | Cytochrome P-450 CYP1A1 - metabolism | DNA-Binding Proteins - genetics | Prenatal Exposure Delayed Effects - genetics | Transcription Factors - metabolism | Tobacco Smoke Pollution - adverse effects | Norway - epidemiology | Fetal Blood | Prenatal Exposure Delayed Effects - chemically induced | Cohort Studies | Complications and side effects | Epigenetic inheritance | Risk factors (Health) | Physiological aspects | Research | Health aspects | Smoking in pregnancy | Index Medicus | Rope | Health | Deoxyribonucleic acid | Smoke | Children | Smoking
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 267 - 275
Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic hydrocarbons; therefore, its inhibition interferes with the carcinogenesis... 
Naringenin | CYP1A1 inhibitor | Dihydroxybergamottin | Molecular modeling | MOLECULAR-DYNAMICS | IN-VITRO INHIBITION | SIMVASTATIN METABOLISM | PARTICLE MESH EWALD | CYTOCHROMES P450 1A1 | O-DEETHYLATION | SUBSTRATE-BINDING | CARCINOGEN METABOLISM | TOXICOLOGY | HUMAN-LIVER-MICROSOMES | Cytochrome P-450 CYP1A1 - genetics | Rats, Wistar | Humans | Molecular Conformation | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Cytochrome P-450 Enzyme Inhibitors - metabolism | Anticarcinogenic Agents - metabolism | Flavanones - chemistry | Microsomes, Liver - drug effects | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Anticarcinogenic Agents - pharmacology | Furocoumarins - chemistry | Binding, Competitive | Recombinant Proteins - metabolism | Catalytic Domain | Furocoumarins - metabolism | Furocoumarins - pharmacology | Citrus paradisi - chemistry | Flavanones - pharmacology | Food-Drug Interactions | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A1 - chemistry | Molecular Dynamics Simulation | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Flavanones - metabolism | Fruit and Vegetable Juices - analysis | Ligands | Molecular Docking Simulation | Cytochrome P-450 | Fruit juices | Physiological aspects | Polycyclic aromatic hydrocarbons | Index Medicus | Enzymes | Carcinogens | Inhibitors | Computation | Grapefruit | Mathematical models | Juices | Inhibition
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