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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 27, pp. 11115 - 11120
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear. Here, we show that the... 
Bone resorption | Enzymes | Cell lines | Stem cells | Bones | Osteoclasts | Cultured cells | Bone marrow cells | Cigarette smoking | Aryl hydrocarbon receptors | Osteoblast | Skeletal remodeling | Toxicology | Bone formation | toxicology | TARGET | RESORPTION | MULTIDISCIPLINARY SCIENCES | osteoblast | AHR | skeletal remodeling | CANCER | IN-VITRO | INHIBITION | METABOLISM | bone formation | CIGARETTE-SMOKE | HEALTH | OSTEOCLAST DIFFERENTIATION | Smoking - adverse effects | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Aryl Hydrocarbon Hydroxylases - biosynthesis | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP1A2 - deficiency | Bone Resorption - metabolism | Female | Cytochrome P-450 CYP1A1 - deficiency | Disease Models, Animal | Bone Resorption - etiology | Benzo(a)pyrene - toxicity | Smoke - adverse effects | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Smoking - genetics | Receptors, Aryl Hydrocarbon - physiology | Tobacco - toxicity | Mice, Knockout | Enzyme Induction - genetics | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Cytochrome P-450 CYP1A2 - biosynthesis | Bone Resorption - pathology | Cytochrome P-450 CYP1B1 | Polychlorinated Dibenzodioxins - toxicity | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Osteoporosis | Carcinogens | Cocarcinogens | Hydrocarbons | Physiological aspects | Health aspects | Smoking | Index Medicus | Biological Sciences
Journal Article
Journal Article
Archives of Toxicology, ISSN 0340-5761, 12/2010, Volume 84, Issue 12, pp. 939 - 946
Age-related changes in hepatic expression and activity of cytochrome P450 (CYP) were investigated in male rats aged 3 (weanling), 12 (young), 26 (adult), and... 
Development and aging | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Liver | Drug-metabolizing enzyme | Pharmacology/Toxicology | Expression and activity | Biomedicine general | PROTEIN | DEPENDENT EXPRESSION | TRANSPORTERS | HEPATOCYTE GROWTH-FACTOR | INDUCIBILITY | INDUCTION | DRUG-METABOLIZING-ENZYMES | MESSENGER-RNA | GENE-EXPRESSION | TOXICOLOGY | LIVER-MICROSOMES | Aryl Hydrocarbon Hydroxylases - biosynthesis | Liver - enzymology | Cytochrome P-450 CYP3A | Cytochrome P-450 Enzyme System - metabolism | Male | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | Cytochrome P-450 CYP2E1 - biosynthesis | Cytochrome P450 Family 2 | Isoenzymes - metabolism | Cytochrome P-450 CYP2B1 - metabolism | Membrane Proteins - metabolism | Microsomes, Liver - enzymology | Cytochrome P-450 CYP2B1 - biosynthesis | Rats | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Membrane Proteins - biosynthesis | Animals | Aging - physiology | Cytochrome P-450 CYP1A2 - biosynthesis | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 CYP1A1 - biosynthesis | Isoenzymes - biosynthesis | Steroid 16-alpha-Hydroxylase - biosynthesis | Cytochrome b | Xenobiotics | Pharmacy | Cytochrome P-450 | Proteins | Toxicology | Rodents | Age differences
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 2006, Volume 844, Issue 2, pp. 292 - 300
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2014, Volume 280, Issue 1, pp. 138 - 148
Journal Article
Journal Article
Toxicology, ISSN 0300-483X, 2010, Volume 277, Issue 1, pp. 59 - 65
Abstract The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the toxic responses of 2,3,7,8-tetrachlorodibenzo- p... 
Emergency | Cytochrome P450 1A1 | Aryl hydrocarbon receptor | 2,3,7,8-Tetrachlorodibenzo- p-dioxin | Single nucleotide polymorphisms | Gene regulation | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | METABOLIZING ENZYME | HUMAN AH RECEPTOR | GENETIC POLYMORPHISMS | SUSCEPTIBILITY | TCDD | RISK | ESTROGEN-RECEPTOR | CYP1A1 LEVELS | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | ASSOCIATION | Cytochrome P-450 CYP1A1 - genetics | Humans | Genetic Variation - physiology | Breast Neoplasms - metabolism | Liver Neoplasms, Experimental - metabolism | Genetic Variation - drug effects | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms, Experimental - genetics | Cytochrome P-450 Enzyme System - physiology | Cytochrome P-450 CYP1A1 - physiology | Receptors, Aryl Hydrocarbon - genetics | Receptors, Aryl Hydrocarbon - physiology | Gene Expression Regulation - drug effects | Animals | Breast Neoplasms - genetics | Cell Line, Tumor | Cytochrome P-450 CYP1B1 | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Polychlorinated Dibenzodioxins - toxicity | Mice | Polymorphism, Single Nucleotide | Cytochrome P-450 CYP1A1 - biosynthesis | Aryl Hydrocarbon Hydroxylases | Carcinoma, Hepatocellular - metabolism | Herbicides | Messenger RNA | Analysis | Dioxin | Cytochrome P-450 | Breast cancer | Hepatoma | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2009, Volume 237, Issue 1, pp. 119 - 126
Human and rodent cytochrome P450 (CYP) enzymes sometimes exhibit striking species-specific differences in substrate preference and rate of metabolism. Human... 
hCYP1A1_1A2_Cyp1a1/1a2(−/−) BAC-transgenic mouse line | Western immunoblot | Cytochrome P450 1 (CYP1) genes | Human HepG2 cell culture | uPA/SCID chimeric mouse line carrying human hepatocytes | Benzo[a]pyrene hydroxylase, ethoxyresorufin O-deethylase, acetanilide 4-hydroxylase and methoxyresorufin O-demethylase as CYP1A1 and CYP1A2 substrates | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) as P450 inducer | Human risk assessment | Mouse Hepa-1c1c7 cell culture | Bacterial artificial chromosome (BAC) | hCYP1A1_1A2_Cyp1a1/1a2(-/-) BAC-transgenic mouse line | ENZYME-ACTIVITY | TOXICITY | KNOCKOUT MICE | SUBSTRATE-SPECIFICITY | CARCINOGENESIS | METABOLISM | ARYL-HYDROCARBON RECEPTOR | LIVER | GENE-EXPRESSION | EMBRYONIC LETHALITY | PHARMACOLOGY & PHARMACY | as CYP1A1 and CYP1A2 Substrates | TOXICOLOGY | Benzo[a]pyrene hydroxylase, ethoxyresorufin O-deethylase, acetanilide 4-hydroxylase and methoxyresorufin O-demethylase | Cell Line | Cytochrome P-450 CYP1A1 - genetics | Species Specificity | Humans | Liver - metabolism | Mice, Inbred C57BL | Dioxins - pharmacology | Environmental Pollutants - pharmacology | Gene Expression Regulation - physiology | RNA, Messenger - analysis | Mice, Transgenic | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Animals | Cytochrome P-450 CYP1A1 - drug effects | Cytochrome P-450 CYP1A2 - genetics | Models, Animal | Cytochrome P-450 CYP1A2 - drug effects | Liver - cytology | Mice | Enzyme Induction - physiology | Chimera | Hepatocytes - enzymology | Herbicides | Messenger RNA | Dioxin | Cytochrome P-450 | Physiological aspects | Gene expression | Index Medicus | DIOXIN | HUMAN POPULATIONS | HEPATOMAS | CELL CULTURES | CHROMOSOMES | 60 APPLIED LIFE SCIENCES | PLASMINOGEN | HYDROXYLASES | ENZYME ACTIVITY | BENZOPYRENE | RISK ASSESSMENT | GENES | LIVER CELLS | TRANSGENIC MICE | UROKINASE | 1a2 | uPA | BAC-transgenic mouse line | hCYP1A1_1A2_Cyp1a1 | SCID chimeric mouse line carrying human hepatocytes
Journal Article