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Toxicological Sciences, ISSN 1096-6080, 06/2005, Volume 85, Issue 2, pp. 935 - 943
The presence of high affinity ligands for the aryl hydrocarbon receptor (AhR) in cell culture medium has generally been overlooked. Such compounds may confound... 
Tryptophan | Aryl hydrocarbon receptor | 6-formylindolo[3,2-b]carbazole | Light | CYP1A1 MESSENGER-RNA | TRANSIENT INDUCTION | HEPATOCYTES | HIGH-AFFINITY | AH RECEPTOR | aryl hydrocarbon receptor | GENE | light | LIVER | SINGLET OXYGEN | ULTRAVIOLET-B | TOXICOLOGY | EXPRESSION | tryptophan | Carbazoles - chemistry | Cytochrome P-450 CYP1A1 - radiation effects | Tryptophan - chemistry | Riboflavin - pharmacology | Tryptophan - metabolism | Carbazoles - radiation effects | Liver Neoplasms, Experimental - metabolism | Photosensitizing Agents - pharmacology | Spectrometry, Mass, Electrospray Ionization | Teratogens - pharmacology | Culture Media | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - radiation effects | Enzyme Inhibitors - chemistry | Enzyme Induction - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Indoles - pharmacology | Photochemistry | Indoles - radiation effects | Enzyme Inhibitors - pharmacology | Rats | Receptors, Aryl Hydrocarbon - drug effects | Enzyme Inhibitors - radiation effects | Cytochrome P-450 CYP1A1 - metabolism | Animals | Cell Line, Tumor | Cytochrome P-450 CYP1A1 - biosynthesis | Carbazoles - pharmacology | Indoles - chemistry | Teratogens | Cytochrome P-450 CYP1A1/biosynthesis/metabolism/radiation effects | Enzyme Inhibitors/chemistry/pharmacology/radiation effects | Spectrometry; Mass; Electrospray Ionization | Biology | Chemical Sciences | Indoles/chemistry/pharmacology/radiation effects | Analytical Chemistry | Enzyme Induction/drug effects | Biochemistry and Molecular Biology | Biologi | Natural Sciences | Biological Sciences | Riboflavin/pharmacology | Photosensitizing Agents/pharmacology | Liver Neoplasms; Experimental/metabolism | Receptors; Aryl Hydrocarbon/drug effects/metabolism/radiation effects | Tryptophan/chemistry/metabolism | Chemistry | Naturvetenskap | Biokemi och molekylärbiologi | Kemi | Biologiska vetenskaper | Cell Line; Tumor | Cell and molecular biology | Analytisk kemi | Carbazoles/chemistry/pharmacology/radiation effects | Cell- och molekylärbiologi
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 02/2014, Volume 274, Issue 3, pp. 408 - 416
The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo- -dioxin... 
CYP1A1 | ARNT | Hypoxia | AhR | HIF-1α | PCB 126 | HIF-1 alpha | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NUCLEAR TRANSLOCATOR | PROMOTER | STRESS | POLYCHLORINATED-BIPHENYLS | Cytochrome P-450 CYP1A1 - genetics | Skin - cytology | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Skin - metabolism | Humans | Transcriptional Activation | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Hepatocytes - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | RNA, Messenger - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Hepatocytes - drug effects | Promoter Regions, Genetic | Cell Hypoxia - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Liver - metabolism | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Cytochrome P-450 CYP1A1 - metabolism | Hep G2 Cells | Polychlorinated Biphenyls - toxicity | Polychlorinated Dibenzodioxins - toxicity | Protein Binding | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Liver - cytology | Skin - drug effects | Herbicides | Dichloropropane | RNA | Liver | Cytochrome P-450 | Physiological aspects | Skin | Xenobiotics | Cells | Index Medicus | DIOXIN | HYDROCARBONS | POLYCHLORINATED BIPHENYLS | DIMERIZATION | TOXICITY | 60 APPLIED LIFE SCIENCES | LUCIFERASE | XENOBIOTICS | MESSENGER-RNA | METABOLISM | ANOXIA | GENES | LIVER | LIVER CELLS | SKIN | RECEPTORS | hypoxia | oxygen effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 21, pp. 8851 - 8856
UVB radiation-induced signaling in mammalian cells involves two major pathways: one that is initiated through the generation of DNA photoproducts in the... 
Receptors | Messenger RNA | Cell nucleus | Cell lines | Irradiation | Ligands | Cell membranes | Skin | Chromophores | Cells | UVB | EGF receptor | 6-formylindolo[3,2-b]carbazole | Cyclooxygenase-2 | Src | HUMAN SKIN | src | PROTEIN-KINASE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | cyclooxygenase-2 | AH RECEPTOR | INDUCED SIGNAL-TRANSDUCTION | GROWTH-FACTOR RECEPTOR | ARYL-HYDROCARBON RECEPTOR | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | CYP1A1 GENE-EXPRESSION | C-SRC | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Carbazoles - chemistry | Humans | Cytoplasm - metabolism | Tryptophan - metabolism | Indoles - metabolism | Receptor, Epidermal Growth Factor - metabolism | Cell Nucleus - metabolism | Ultraviolet Rays | Receptors, Aryl Hydrocarbon - metabolism | Molecular Structure | Active Transport, Cell Nucleus | Signal Transduction - radiation effects | Basic Helix-Loop-Helix Transcription Factors | Carbazoles - metabolism | Cell Line | Cytoplasm - radiation effects | Gene Expression Regulation | Receptors, Aryl Hydrocarbon - genetics | Cytochrome P-450 CYP1A1 - metabolism | Mice, Knockout | Animals | Proto-Oncogene Proteins pp60(c-src) - metabolism | Mice | Transcription, Genetic - genetics | Indoles - chemistry | COX-2 inhibitors | Ultraviolet radiation | Research | Biological Sciences
Journal Article
1993, Handbook of experimental pharmacology, ISBN 3540559086, Volume 105., xxxiv, 739
Book
Current Medicinal Chemistry, ISSN 0929-8673, 03/2013, Volume 20, Issue 7, pp. 869 - 879
Journal Article
Journal Article
BMC Genomics, ISSN 1471-2164, 06/2011, Volume 12, Issue 1, pp. 333 - 333
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e44472
The study aimed to identify endogenous lipid mediators of metabolic and inflammatory responses of human keratinocytes to solar UV irradiation. Physiologically... 
GROWTH-FACTOR RECEPTOR | OXIDATIVE STRESS | CHEMOKINE EXPRESSION | ACTIVATION | KAPPA | ARYL-HYDROCARBON RECEPTOR | PATHWAY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | ULTRAVIOLET | EGF RECEPTOR | Inflammation - pathology | Keratinocytes - radiation effects | Humans | Oxidation-Reduction - radiation effects | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Receptor, Epidermal Growth Factor - metabolism | Ultraviolet Rays | Time Factors | Isoenzymes - metabolism | Aldehydes - pharmacology | Oxidation-Reduction - drug effects | Surface Properties - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Adult | Signal Transduction - radiation effects | Surface Properties - radiation effects | Cytokines - genetics | Keratinocytes - enzymology | Epidermis - pathology | Cytokines - metabolism | RNA, Messenger - genetics | Cytochrome P-450 CYP1A1 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Gene Expression Regulation - drug effects | Keratinocytes - pathology | Signal Transduction - drug effects | Squalene - pharmacology | Keratinocytes - metabolism | Skin - radiation effects | Cyclooxygenase 2 - metabolism | Cytochrome P-450 CYP1B1 | Gene Expression Regulation - radiation effects | Carbazoles - pharmacology | Dose-Response Relationship, Radiation | Nitric Oxide Synthase Type II - metabolism | Ultraviolet radiation | Keratinocytes | Physiological aspects | Causes of | Genetic aspects | Inflammation | Research | Lipids | Arachidonic acid | Kinases | Machinery | Interleukin 6 | Aromatic compounds | Oxidation | Epidermal growth factor receptors | CYP1B1 gene | U.V. radiation | Cytochrome P450 | Tryptophan | Squalene | Cultures | Gene expression | Carbazole | Cholesterol | Nitric-oxide synthase | Irradiation | Skin | Cyclooxygenase-2 | Tocopherol | Human behavior | Photooxidation
Journal Article
1993, 2nd ed., ISBN 9784062054607, xii, 292
Book
Journal Article