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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1217 - 1228
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6678 - 6692
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers.... 
TARGET | CHEMISTRY, MEDICINAL | PATHWAY | MECHANISMS | BETA-CATENIN | WNT | CANCER | Acyltransferases - antagonists & inhibitors | Maleimides - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Microsomes, Liver - metabolism | Maleimides - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Maleimides - pharmacokinetics | Cytochrome P-450 CYP1A2 Inhibitors - pharmacokinetics | Maleimides - chemical synthesis | HEK293 Cells | Pyridazines - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - pharmacology | Wnt Signaling Pathway | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Rats | Cytochrome P-450 CYP1A2 Inhibitors - chemical synthesis | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - chemical synthesis | Xenograft Model Antitumor Assays | Animals | Cytochrome P-450 CYP1A2 Inhibitors - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - chemical synthesis | High-Throughput Screening Assays | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Cytochrome P-450 CYP1A2 Inhibitors - administration & dosage | Cell Line, Tumor | Pyridazines - pharmacokinetics | Mice, Inbred BALB C | Index Medicus
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Life Sciences, ISSN 0024-3205, 12/2017, Volume 190, pp. 46 - 51
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Drug Metabolism and Disposition, ISSN 0090-9556, 11/2005, Volume 33, Issue 11, pp. 1723 - 1728
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Toxicological Sciences, ISSN 1096-6080, 2012, Volume 125, Issue 2, pp. 345 - 358
Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. Individual susceptibility to AA-induced disease likely reflects... 
Aristolochic acid ia | Cytochrome P450 | Cyp1a-humanized mouse models | Balkan endemic nephropathy | Metabolism | Aristolochic acid nephropathy | Dna adducts | aristolochic acid nephropathy | DNA-ADDUCTS | P450 1A1 | PHASE-II | METABOLIC-ACTIVATION | cytochrome P450 | MOUSE LINE | RISK-FACTOR | REDUCTIVE ACTIVATION | GENE-EXPRESSION | metabolism | TOXICOLOGY | DNA adducts | CYP1A-humanized mouse models | aristolochic acid Ia | CHINESE HERBS | Cytochrome P-450 CYP1A1 - genetics | Inactivation, Metabolic | Liver - enzymology | Humans | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Chromatography, High Pressure Liquid | Carcinogens - metabolism | Aristolochic Acids - urine | DNA Adducts - metabolism | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 Inhibitors | Cytosol - enzymology | Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Female | Microsomes, Liver - enzymology | Aristolochic Acids - toxicity | Recombinant Proteins - metabolism | Oxidation-Reduction | Dealkylation | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Urologic Neoplasms - chemically induced | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Mice, Knockout | Animals | Aristolochic Acids - metabolism | Mice | Urothelium - drug effects | Index Medicus | Biotransformation and Toxicokinetics
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Drug Metabolism and Disposition, ISSN 0090-9556, 03/2010, Volume 38, Issue 3, pp. 376 - 385
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