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1. Full Text Variants in the CYP2B6 3UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs
by Burgess, Kimberly S and Ipe, Joseph and Swart, Marelize and Metzger, Ingrid F and Lu, Jessica and Gufford, Brandon T and Thong, Nancy and Desta, Zeruesenay and Gaedigk, Roger and Pearce, Robin E and Gaedigk, Andrea and Liu, Yunlong and Skaar, Todd C
Clinical pharmacology and therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 130 - 138
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2B6 Inducers - metabolism | Area Under Curve | Humans | Middle Aged | 3' Untranslated Regions - genetics | Benzoxazines - metabolism | Male | MicroRNAs - metabolism | Healthy Volunteers | Cytochrome P-450 CYP2B6 - metabolism | Young Adult | Benzoxazines - pharmacokinetics | Computer Simulation | Pharmacogenomic Variants | Adult | Female | Binding Sites | Alkynes | Cytochrome P-450 CYP2B6 - genetics | Cyclopropanes | Hep G2 Cells | Cytochrome P-450 CYP2B6 Inducers - pharmacokinetics | Adolescent | Alleles | Polymorphism, Single Nucleotide | In Vitro Techniques | Index Medicus | Abridged Index Medicus
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2. Full Text Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes
by Chen, Chao and Liu, Jingbao and Halpert, James R and Wilderman, P. Ross
Biochemistry (Easton), ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2B1 - genetics | Aniline Compounds | Humans | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Structure-Activity Relationship | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Inhibitory Concentration 50 | Cytochrome P-450 CYP2B1 - metabolism | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Mutagenesis, Site-Directed | Oxidation-Reduction | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Rats | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Amino Acid Substitution | Research | Chemical properties | Aniline | Cytochrome P-450 | Index Medicus
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3. Full Text Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
by Kazui, Miho and Nishiya, Yumi and Ishizuka, Tomoko and Hagihara, Katsunobu and Farid, Nagy A and Okazaki, Osamu and Ikeda, Toshihiko and Kurihara, Atsushi
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
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4. Full Text Establishment of in silico prediction models for CYP3A4 and CYP2B6 induction in human hepatocytes by multiple regression analysis using azole compounds
by Nagai, Mika and Konno, Yoshihiro and Satsukawa, Masahiro and Yamashita, Shinji and Yoshinari, Kouichi
Drug metabolism and disposition, ISSN 0090-9556, 2016, Volume 44, Issue 8, pp. 1390 - 1398
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Middle Aged | Male | Structure-Activity Relationship | Cytochrome P-450 CYP3A Inducers - toxicity | RNA, Messenger - biosynthesis | Drug Interactions | Cytochrome P-450 CYP2B6 - biosynthesis | Cytochrome P-450 CYP2B6 Inducers - pharmacology | Cytochrome P-450 CYP3A - genetics | Time Factors | Computer Simulation | Adult | Azoles - toxicity | Molecular Structure | Principal Component Analysis | Hepatocytes - drug effects | Cytochrome P-450 CYP3A - biosynthesis | Cytochrome P-450 CYP2B6 - genetics | Cells, Cultured | Models, Statistical | Azoles - pharmacology | Azoles - chemistry | Cytochrome P-450 CYP2B6 Inducers - chemistry | Regression Analysis | Cytochrome P-450 CYP2B6 Inducers - toxicity | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A Inducers - chemistry | Hepatocytes - enzymology | Index Medicus
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5. Full Text Psoralen, a mechanism-based inactivator of CYP2B6
by Ji, Lin and Lu, Dan and Cao, Jiaojiao and Zheng, Liwei and Peng, Ying and Zheng, Jiang
Chemico-biological interactions, ISSN 0009-2797, 10/2015, Volume 240, pp. 346 - 352
Mechanism-based inactivation | Psoralen | Reactive metabolite | Cytochrome P450 2B6 | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Dose-Response Relationship, Drug | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Ficusin - chemistry | Ticlopidine - pharmacology | Cytochrome P-450 CYP2B6 Inhibitors - chemistry | Ficusin - pharmacology | Ticlopidine - metabolism | Enzyme Activation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Cytochrome P-450 CYP2B6 - metabolism | Coumarins | Evaluation | Cytochrome P-450 | Ticlopidine | Index Medicus
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6. Full Text Enantioselective inhibition of Cytochrome P450-mediated drug metabolism by a novel antithrombotic agent, S002-333: Major effect on CYP2B6
by Bhateria, Manisha and Ramakrishna, Rachumallu and Puttrevu, Santosh Kumar and Saxena, Anil K and Bhatta, Rabi Sankar
Chemico-biological interactions, ISSN 0009-2797, 08/2016, Volume 256, pp. 257 - 265
Stereoselectivity | CYP2B6 inhibition | Antithrombotic drugs | IC50 shift | Drug-drug interaction | S002-333 | shift | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Fibrinolytic Agents - chemistry | Sulfonamides - chemistry | Cytochrome P-450 CYP2B6 Inhibitors - chemistry | Stereoisomerism | Humans | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Fibrinolytic Agents - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Carbolines - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Carbolines - chemistry | Protein Isoforms - metabolism | Microsomes, Liver - drug effects | Sulfonamides - metabolism | Cytochrome P-450 Enzyme Inhibitors - chemistry | Physiological aspects | Drug discovery | Enantiomers | Liver | Cytochrome P-450 | Cardiovascular agents | Index Medicus
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7. Full Text Ser100-Phosphorylated ROR alpha Orchestrates CAR and HNF4 alpha to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6
by Fashe, Muluneh and Hashiguchi, Takuyu and Negishi, Masahiko and Sueyoshi, Tatsuya
Molecular pharmacology, ISSN 0026-895X, 03/2020, Volume 97, Issue 3, pp. 191 - 201
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Phenobarbital - pharmacology | Phosphorylation - physiology | Chromatin - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Cytochrome P-450 CYP2B6 - genetics | Humans | Cells, Cultured | Hepatocytes - metabolism | Oligopeptides - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism | Cytochrome P-450 CYP2B6 - biosynthesis | Cytochrome P-450 CYP2B6 Inducers - pharmacology | Phosphorylation - drug effects | Hepatocytes - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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8. Full Text Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites
by Uwimana, Eric and Ruiz, Patricia and Li, Xueshu and Lehmler, Hans-Joachim
Environmental science & technology, ISSN 0013-936X, 02/2019, Volume 53, Issue 4, pp. 2114 - 2123
Engineering | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Cytochrome P-450 CYP2A6 | Hydroxylation | Stereoisomerism | Cytochrome P-450 CYP2E1 | Humans | Polychlorinated Biphenyls | Cytochrome P-450 CYP2B6 | Cytochrome | Brain | Cytochrome P450 | CYP1A2 protein | Metabolism | Neurodevelopmental disorders | PCB compounds | Neurotoxicity | Hexachlorobiphenyl | Metabolites | Biotransformation | Isoforms | Polychlorinated biphenyls--PCB | Oxidation | Cytochromes P450 | Index Medicus
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9. Full Text CYP2B6 and Bupropion's Smoking‐Cessation Pharmacology: The Role of Hydroxybupropion
by Zhu, A Z X and Cox, L S and Nollen, N and Faseru, B and Okuyemi, K S and Ahluwalia, J S and Benowitz, N L and Tyndale, R F
Clinical pharmacology and therapeutics, ISSN 0009-9236, 12/2012, Volume 92, Issue 6, pp. 771 - 777
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Bupropion - metabolism | Predictive Value of Tests | Double-Blind Method | Humans | Smoking - drug therapy | African Americans | Bupropion - analogs & derivatives | Logistic Models | Treatment Outcome | Antidepressive Agents, Second-Generation - therapeutic use | Aryl Hydrocarbon Hydroxylases - metabolism | Kinetics | Antidepressive Agents, Second-Generation - metabolism | Odds Ratio | Oxidoreductases, N-Demethylating - metabolism | Cytochrome P-450 CYP2B6 | Bupropion - therapeutic use | Smoking Cessation | Drug metabolism | Smoking cessation programs | Cytochromes | Bupropion | Research | Metabolites | Index Medicus | Abridged Index Medicus
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10. Full Text Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers
by Zubiaur, Pablo and Saiz-Rodriguez, Miriam and Ochoa, Dolores and Belmonte, Carmen and Roman, Manuel and Mejia, Gina and Martin-Vilchez, Samuel and Abad-Santos, Francisco
The pharmacogenomics journal, ISSN 1470-269X, 04/2020, Volume 20, Issue 2, pp. 235 - 245
Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cytochrome P-450 | Drug metabolism | Genetic aspects | Dosage and administration | Single nucleotide polymorphisms | Health aspects | Efavirenz | Antiretroviral drugs | RNA-directed DNA polymerase | Non-nucleoside reverse transcriptase inhibitors | Nucleoside reverse transcriptase inhibitors | Cytochrome P450 | Human immunodeficiency virus--HIV | Single-nucleotide polymorphism | Pharmacokinetics | Index Medicus
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11. Full Text Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition
by Kharasch, Evan D and Crafford, Amanda
Clinical pharmacology and therapeutics, ISSN 0009-9236, 01/2019, Volume 105, Issue 1, pp. 142 - 152
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tissue Distribution - physiology | Antidepressive Agents, Second-Generation - chemistry | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Tissue Distribution - drug effects | Administration, Oral | Cytochrome P-450 CYP2B6 - genetics | Stereoisomerism | Humans | Bupropion - blood | Male | Antidepressive Agents, Second-Generation - administration & dosage | Bupropion - administration & dosage | Polymorphism, Single Nucleotide - drug effects | Antidepressive Agents, Second-Generation - blood | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Bupropion - chemistry | Polymorphism, Single Nucleotide - genetics | Adult | Female | Cytochrome P-450 CYP2D6 Inhibitors - blood | Index Medicus | Abridged Index Medicus | CYP2B6 | P450 oxidoreductase | stereochemistry | cytochrome P450 2B6 | CYP2C19 | bupropion | pharmacogenetics
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