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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1217 - 1228
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2015, Volume 43, Issue 2, pp. 182 - 189
Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory... 
IN-VITRO | WARFARIN | KINETICS | HUMANS | PHARMACOLOGY & PHARMACY | PLASMA-PROTEIN BINDING | DESETHYLAMIODARONE | DISCOVERY | DIALYSIS | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Liver - enzymology | Cytochrome P-450 CYP2D6 Inhibitors - metabolism | Expert Systems | Humans | Middle Aged | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Cytochrome P-450 CYP2C9 Inhibitors - chemistry | Amiodarone - blood | Anti-Arrhythmia Agents - metabolism | Amiodarone - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Liver - drug effects | Amiodarone - pharmacokinetics | Computer Simulation | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP2C9 Inhibitors - metabolism | Adult | Female | Cytochrome P-450 CYP2C9 Inhibitors - blood | Reproducibility of Results | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - blood | Administration, Oral | Liver - metabolism | Amiodarone - antagonists & inhibitors | Anti-Arrhythmia Agents - chemistry | Anti-Arrhythmia Agents - pharmacokinetics | Anti-Arrhythmia Agents - administration & dosage | Amiodarone - analogs & derivatives | Amiodarone - metabolism | Cytochrome P-450 CYP3A Inhibitors - metabolism | Models, Biological | Biotransformation - drug effects | Cytochrome P-450 CYP2D6 Inhibitors - blood | Infusions, Intravenous | Cytochrome P-450 CYP2C9 Inhibitors - pharmacokinetics | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 03/2009, Volume 5, Issue 3, pp. e1000433 - e1000433
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2007, Volume 5, Issue 12, pp. 2429 - 2436
Background:  Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y 12 adenosine diphosphate receptor. The... 
clopidogrel | prasugrel | receptor | P2Y | platelet function | thienopyridines | cytochrome P450 enzymes | Prasugrel | Cytochrome P450 enzymes | Platelet function | Thienopyridines | Clopidogrel | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | ANTIPLATELET THERAPY | ATHEROTHROMBOTIC EVENTS | INCREASED RISK | P2Y receptor | THIENOPYRIDINE P2Y INHIBITOR | PERIPHERAL VASCULAR DISEASE | ST-SEGMENT ELEVATION | HEMATOLOGY | CORONARY-ARTERY-DISEASE | PLATELET REACTIVITY | ACTIVE METABOLITE | Cytochrome P-450 CYP2C9 | Prasugrel Hydrochloride | Ticlopidine - pharmacology | Area Under Curve | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Mixed Function Oxygenases - metabolism | Reference Values | Thiophenes - blood | Platelet Aggregation Inhibitors - blood | Receptors, Purinergic P2Y12 | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Retrospective Studies | Ticlopidine - pharmacokinetics | Piperazines - pharmacokinetics | Blood Platelets - drug effects | Piperazines - blood | Purinergic P2 Receptor Antagonists | Thiophenes - pharmacology | Genotype | Clinical Trials as Topic | Piperazines - pharmacology | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Cross-Over Studies | Thiophenes - pharmacokinetics | Phenotype | Prodrugs - pharmacokinetics | Blood Platelets - metabolism | Cytochrome P-450 CYP2C19 | Receptors, Purinergic P2 - metabolism | Mixed Function Oxygenases - genetics | Prodrugs - pharmacology | Research Design | Ticlopidine - blood | Adenosine diphosphate | Genetic aspects | Metabolites | Cytochrome P-450 | Index Medicus
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 05/2011, Volume 71, Issue 5, pp. 737 - 750
Journal Article
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 2015, Volume 43, Issue 6, pp. 819 - 828
Journal Article
Journal Article