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1. Full Text Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?
by Gazzaz, Malaz and Kinzig, Martina and Schaeffeler, Elke and Jübner, Martin and Hsin, Chih‐hsuan and Li, Xia and Taubert, Max and Trueck, Christina and Iltgen‐Breburda, Juliane and Kraus, Daria and Queckenberg, Christian and Stoffel, Marc and Schwab, Matthias and Sörgel, Fritz and Fuhr, Uwe
Clinical pharmacology and therapeutics, ISSN 0009-9236, 12/2018, Volume 104, Issue 6, pp. 1249 - 1259
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Intestines - drug effects | Arylamine N-Acetyltransferase - metabolism | Liver - enzymology | Humans | Ethanol - administration & dosage | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - adverse effects | Male | Young Adult | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Ethanol - adverse effects | Adult | Female | Alcohol Drinking - metabolism | Cytochrome P-450 CYP2C9 - metabolism | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Risk Assessment | Genotype | Alcohol Drinking - adverse effects | Cytochrome P-450 CYP1A2 - metabolism | Cytochrome P-450 Enzyme Inhibitors - administration & dosage | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Cross-Over Studies | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Phenotype | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP1A2 Inhibitors - administration & dosage | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 CYP2C19 - metabolism | Pharmacokinetics | Intestines - enzymology | Index Medicus | Abridged Index Medicus
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2. Full Text Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease
by Craig D. Fisher and Andrew J. Lickteig and Lisa M. Augustine and James Ranger-Moore and Jonathan P. Jackson and Stephen S. Ferguson and Nathan J. Cherrington
Drug metabolism and disposition, ISSN 0090-9556, 10/2009, Volume 37, Issue 10, pp. 2087 - 2094
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Other diseases. Semiology | Pharmacology. Drug treatments | Cytochrome P-450 CYP2C9 | Fatty Liver - genetics | Cytochrome P-450 CYP2D6 - genetics | Oxidoreductases, N-Demethylating - genetics | Fatty Liver - metabolism | Fatty Liver - pathology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Disease Progression | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP2C19 | Cytochrome P-450 CYP1A2 - genetics | Fatty Liver - enzymology | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Microsomes, Liver - enzymology | Oxidoreductases, N-Demethylating - metabolism | Cytochrome P-450 CYP2B6 | Index Medicus
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3. Full Text Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria
by Deye, Gregory and McCarthy, William F and Bennett, Jason W and Pybus, Brandon S and Melendez, Victor and Ockenhouse, Christian F and Yadava, Anjali and Tosh, Donna and Sousa, Jason C
The New England journal of medicine, ISSN 0028-4793, 10/2013, Volume 369, Issue 14, pp. 1381 - 1382
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Recurrence | Plasmodium vivax - drug effects | Humans | Middle Aged | Metabolism, Inborn Errors | Male | Parasitemia - drug therapy | Cytochrome P-450 CYP2D6 - deficiency | Young Adult | Phenotype | Primaquine - metabolism | Malaria, Vivax - drug therapy | Primaquine - therapeutic use | Treatment Failure | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Adult | Female | Cytochrome | Genotype & phenotype | Enzymes | Malaria | Metabolites | Primaquine | FDA approval | Genetic factors | Metabolism | Drug dosages | Index Medicus | Abridged Index Medicus
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4. Full Text Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors
by Hicks, JK and Bishop, JR and Sangkuhl, K and Müller, DJ and Ji, Y and Leckband, SG and Leeder, JS and Graham, RL and Chiulli, DL and LLerena, A and Skaar, TC and Scott, SA and Stingl, JC and Klein, TE and Caudle, KE and Gaedigk, A and Clinical Pharmacogenetics Implementation Consortium
Clinical pharmacology and therapeutics, ISSN 0009-9236, 08/2015, Volume 98, Issue 2, pp. 127 - 134
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Serotonin Uptake Inhibitors - pharmacokinetics | Risk Assessment | Humans | Risk Factors | Cytochrome P-450 CYP2C19 - genetics | Serotonin Uptake Inhibitors - adverse effects | Genotype | Polymorphism, Genetic | Drug Dosage Calculations | Phenotype | Serotonin Uptake Inhibitors - administration & dosage | Biotransformation | Patient Safety | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 CYP2C19 - metabolism | Pharmacogenetics - standards | Pharmacogenetics | Medical societies | Practice guidelines (Medicine) | Serotonin uptake inhibitors | Dosage and administration | Health aspects | Standards | Index Medicus | Abridged Index Medicus | CPIC Guidelines
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5. Full Text Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method
by Bosilkovska, Marija and Samer, Caroline and Déglon, Julien and Thomas, Aurélien and Walder, Bernhard and Desmeules, Jules and Daali, Youssef
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Caffeine - administration & dosage | Humans | Midazolam - administration & dosage | Male | Genotyping Techniques | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Adult | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cross-Over Studies | Phenotype | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Index Medicus
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6. Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction: A systematic review on CYP2C9, CYP2C19 and CYP2D6
by Bahar, Muh Akbar and Setiawan, Didik and Hak, Eelko and Wilffert, Bob
Pharmacogenomics, ISSN 1462-2416, 05/2017, Volume 18, Issue 7, pp. 701 - 739
drug-drug interaction (DDI) | CYP2C9 | drug-metabolizing enzyme | CYP2C19 | CYP2D6 | drug-drug-gene interaction (DDGI) | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Pharmacogenetics - methods | Pharmacogenetics - trends | Animals | Drug Interactions - genetics | Humans | Cytochrome P-450 CYP2C19 - genetics | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 CYP2C19 - metabolism | Inactivation, Metabolic - genetics | Cytochrome P-450 CYP2C9 - metabolism | Cytochrome P-450 CYP2C9 - genetics
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7. Full Text Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity
by Ahern, Thomas P and Hertz, Daniel L and Damkier, Per and Ejlertsen, Bent and Hamilton-Dutoit, Stephen J and Rae, James M and Regan, Meredith M and Thompson, Alastair M and Lash, Timothy L and Cronin-Fenton, Deirdre P
American journal of epidemiology, ISSN 0002-9262, 01/2017, Volume 185, Issue 2, pp. 75 - 85
Tamoxifen | Cytochrome P-450 2D6 | Breast neoplasms | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Tamoxifen - metabolism | Cytochrome P-450 CYP2D6 - genetics | Humans | Genotype | Loss of Heterozygosity | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Treatment Failure | Tamoxifen - analogs & derivatives | Breast Neoplasms - mortality | Female | Neoplasm Recurrence, Local - genetics | DNA, Neoplasm - analysis | Prevention | Care and treatment | Usage | Receptors | Relapse | Cytochrome P-450 | Estrogen | Breast cancer | Research | Health aspects | Cancer | Index Medicus | cytochrome P-450 2D6 | Systematic Reviews, Meta- and Pooled Analyses | breast neoplasms | tamoxifen
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8. Full Text Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes
by Fohner, Alison and Muzquiz, LeeAnna I and Austin, Melissa A and Gaedigk, Andrea and Gordon, Adam and Thornton, Timothy and Rieder, Mark J and Pershouse, Mark A and Putnam, Elizabeth A and Howlett, Kevin and Beatty, Patrick and Thummel, Kenneth E and Woodahl, Erica L
Pharmacogenetics and genomics, ISSN 1744-6872, 08/2013, Volume 23, Issue 8, pp. 403 - 414
indigenous populations | CYP2C9 | Alaska Native | pharmacogenomics | CYP2D6 | cytochrome P450 | American Indian | CYP3A4 | CYP3A5 | pharmacogenetics | Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Cytochrome P-450 CYP2C9 | Cytochrome P-450 CYP3A - pharmacology | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | DNA Copy Number Variations | Genetic Variation | Young Adult | Cytochrome P-450 CYP3A - genetics | Aged, 80 and over | Northwestern United States | Adult | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP2D6 - pharmacology | Aryl Hydrocarbon Hydroxylases - pharmacology | Pharmacogenetics | African Americans - genetics | Sequence Analysis, DNA | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP3A - metabolism | Adolescent | Indians, North American - genetics | Cytochrome P-450 CYP2D6 - metabolism | Aged | Polymorphism, Single Nucleotide | Index Medicus | Cytochrome P450
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9. Full Text Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
by Gasche, Yvan and Daali, Youssef and Fathi, Marc and Chiappe, Alberto and Cottini, Silvia and Dayer, Pierre and Desmeules, Jules
The New England journal of medicine, ISSN 0028-4793, 12/2004, Volume 351, Issue 27, pp. 2827 - 2831
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Dextromethorphan - therapeutic use | Antitussive Agents - poisoning | Cough - drug therapy | Cytochrome P-450 CYP3A | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Dextromethorphan - metabolism | Male | Codeine - administration & dosage | Codeine - metabolism | Lung Diseases, Fungal - drug therapy | Antitussive Agents - metabolism | Codeine - poisoning | Cytochrome P-450 CYP2D6 - genetics | Analgesics, Opioid - poisoning | Genotype | Cough - etiology | Phenotype | Antitussive Agents - administration & dosage | Pneumonia - drug therapy | Analgesics, Opioid - administration & dosage | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Pneumonia - complications | Analgesics, Opioid - metabolism | Methylation | Pneumonia | Dosage and administration | Drug therapy | Bacterial pneumonia | Cough | Codeine | Index Medicus | Abridged Index Medicus
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