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Journal Article
Clinical pharmacology and therapeutics, ISSN 0009-9236, 12/2018, Volume 104, Issue 6, pp. 1249 - 1259
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2004, Volume 32, Issue 4, pp. 447 - 454
... CYP3A4. CYP2D6 had the highest activity for O -demethylation. Multienzyme, Michaelis-Menten kinetics were observed for both oxidative reactions in microsomes prepared from five human livers... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Intestines - drug effects | Microsomes - metabolism | Intestinal Mucosa - metabolism | Morphinans - antagonists & inhibitors | Oxidoreductases, N-Demethylating - genetics | Quinidine - antagonists & inhibitors | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Ketoconazole - metabolism | Metabolic Clearance Rate | Ketoconazole - pharmacology | Microsomes - drug effects | Morphinans - metabolism | Oxymorphone - metabolism | Microsomes, Liver - drug effects | Quinidine - adverse effects | Biotransformation | Protein Binding - drug effects | Molecular Structure | Oxidoreductases, N-Demethylating - metabolism | Oxycodone - metabolism | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP2D6 - pharmacology | Morphinans - chemistry | Aryl Hydrocarbon Hydroxylases - pharmacology | Oxycodone - pharmacology | Oxymorphone - chemistry | Quinidine - pharmacology | Microsomes, Liver - chemistry | Aryl Hydrocarbon Hydroxylases - metabolism | Intestines - ultrastructure | Oxidoreductases, N-Demethylating - pharmacology | Methylation - drug effects | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Kinetics | Index Medicus
Journal Article
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 09/2004, Volume 310, Issue 3, pp. 1062 - 1075
...; 4-hydroxy-TAM formation catalyzed by CYP2D6 ( and other P450s) represents a minor route. Other minor primary metabolites include alpha -, 3-, and 4'-hydroxyTAM and one unidentified metabolite (M... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tamoxifen - metabolism | Oxidation-Reduction | Cytochrome P-450 CYP3A | Biotransformation | Humans | Microsomes, Liver - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Microsomes, Liver - enzymology | Statistics as Topic | Kinetics
Journal Article
Journal Article