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1. Full Text Structures of human cytochrome P-450 2E1: Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
by Porubsky, Patrick R and Meneely, Kathleen M and Scott, Emily E
The Journal of biological chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 48, pp. 33698 - 33707
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Acetaminophen - adverse effects | Arachidonic Acid - metabolism | Heme - metabolism | Cytochrome P-450 CYP2E1 Inhibitors | Enzyme Inhibitors - metabolism | Nitrosamines - metabolism | Humans | Imidazoles - chemistry | Models, Molecular | Cytochrome P-450 CYP2E1 - metabolism | Hydroxylation - physiology | Carcinogens - metabolism | Smoking - metabolism | Heme - chemistry | Hydrogen Bonding | Analgesics, Non-Narcotic - adverse effects | Enzyme Inhibitors - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Structure, Secondary - physiology | Xenobiotics - metabolism | Cytochrome P-450 CYP2E1 - chemistry | Imidazoles - metabolism | Index Medicus
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2. Full Text Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease
by Craig D. Fisher and Andrew J. Lickteig and Lisa M. Augustine and James Ranger-Moore and Jonathan P. Jackson and Stephen S. Ferguson and Nathan J. Cherrington
Drug metabolism and disposition, ISSN 0090-9556, 10/2009, Volume 37, Issue 10, pp. 2087 - 2094
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Other diseases. Semiology | Pharmacology. Drug treatments | Cytochrome P-450 CYP2C9 | Fatty Liver - genetics | Cytochrome P-450 CYP2D6 - genetics | Oxidoreductases, N-Demethylating - genetics | Fatty Liver - metabolism | Fatty Liver - pathology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Disease Progression | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP2C19 | Cytochrome P-450 CYP1A2 - genetics | Fatty Liver - enzymology | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Microsomes, Liver - enzymology | Oxidoreductases, N-Demethylating - metabolism | Cytochrome P-450 CYP2B6 | Index Medicus
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3. Full Text Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance
by Haihong Zong and Michal Armoni and Chava Harel and Eddy Karnieli and Jeffrey E. Pessin
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 03/2012, Volume 302, Issue 5, pp. 532 - 539
Energy expenditure | Endocrinology & Metabolism | Physiology | Life Sciences & Biomedicine | Science & Technology | Liver - pathology | Hyperlipidemias - blood | Fatty Liver - pathology | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Male | Cytochrome P-450 CYP2E1 - genetics | Mice, 129 Strain | Muscle Fibers, Skeletal - metabolism | Molecular Targeted Therapy | Glucose Intolerance - blood | Glucose Intolerance - prevention & control | Biological Transport | Glucose Intolerance - etiology | Cytochrome P-450 CYP2E1 - physiology | Obesity - etiology | Cytokines - blood | Signal Transduction | Liver - metabolism | Fatty Liver - prevention & control | Insulin Resistance | Obesity - physiopathology | Hyperlipidemias - prevention & control | Mice, Knockout | Obesity - metabolism | Insulin - metabolism | Animals | Hyperlipidemias - etiology | Obesity - prevention & control | Glucose - metabolism | Mice | Fatty Liver - etiology | Obesity | Cytokines | Diet | Rodents | Motor ability | Insulin resistance | Glucose | Index Medicus | energy expenditure
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4. Full Text MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity
by Gill, Pritmohinder and Bhattacharyya, Sudeepa and McCullough, Sandra and Letzig, Lynda and Mishra, Prasun J and Luo, Chunqiao and Dweep, Harsh and James, Laura
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12331 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Drug Overdose - metabolism | Up-Regulation | Drug Overdose - blood | Humans | 3' Untranslated Regions - genetics | Child, Preschool | Male | MicroRNAs - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Drug Overdose - etiology | Female | Protein Biosynthesis - genetics | Binding Sites | Child | Cell Line | Drug Overdose - genetics | Acetaminophen - toxicity | Cytochrome P-450 CYP1A2 - metabolism | Hepatocytes | Cytochrome P-450 CYP3A - metabolism | Adolescent | MicroRNAs - blood | Toxicity | Cytochrome P450 | mRNA | CYP1A2 protein | Protein adducts | Analgesics | 3' Untranslated regions | Acetaminophen | Isoforms | miRNA | Overdose | Children | Binding sites | Index Medicus
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5. Full Text Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice
by Kristina K. Wolf and Sheryl G. Wood and Jenna L. Allard and Jane A. Hunt and Nadia Gorman and Brooke W. Walton-Strong and Juliana G. Szakacs and Su X. Duan and Qin Hao and Michael H. Court and Lisa L. von Moltke and David J. Greenblatt and Vsevolod Kostrubsky and Elizabeth H. Jeffery and Steven A. Wrighton and Frank J. Gonzalez and Peter R. Sinclair and Jacqueline F. Sinclair
Drug metabolism and disposition, ISSN 0090-9556, 07/2007, Volume 35, Issue 7, pp. 1223 - 1231
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Liver - pathology | Liver - enzymology | Cytochrome P-450 Enzyme Inhibitors | Ethanol - toxicity | Glutathione - metabolism | Liver Diseases - pathology | Cytochrome P-450 Enzyme System - metabolism | Male | Alanine Transaminase - blood | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Testosterone - metabolism | Glucuronides - metabolism | Liver - drug effects | Enzyme Induction - drug effects | Troleandomycin - pharmacology | Benzoquinones - metabolism | Disease Models, Animal | Severity of Illness Index | Hydroxylation | Imines - metabolism | Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP1A2 - metabolism | Mice, Knockout | Drug Synergism | Cytochrome P-450 CYP2E1 - deficiency | Animals | Acetaminophen | Cytochrome P-450 Enzyme System - biosynthesis | Chemical and Drug Induced Liver Injury | Mice | Liver Diseases - metabolism | Pentanols - toxicity | Index Medicus
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6. Full Text CYP Induction-Mediated Drug Interactions: in Vitro Assessment and Clinical Implications
by Lin, Jiunn H
Pharmaceutical research, ISSN 0724-8741, 6/2006, Volume 23, Issue 6, pp. 1089 - 1116
Biochemistry, general | glucocorticoid receptor | interindividual variability | cross talk | pregnane X receptor | aryl hydrocarbon receptor | xenobiotic responsive elements | Biomedical Engineering | hepatic and intestinal CYP induction | Biomedicine | constitutive androstane receptor | Pharmacy | Medical Law | species differences | Pharmacology/Toxicology | in vitro / in vivo extrapolation | Aryl hydrocarbon receptor | In vitro/in vivo extrapolation | Interindividual variability | Pregnane X receptor | Glucocorticoid receptor | Cross talk | Constitutive androstane receptor | Species differences | Hepatic and intestinal CYP induction | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cytochrome P-450 CYP2B1 - genetics | Cytochrome P-450 CYP3A - biosynthesis | Liver - enzymology | Receptor Cross-Talk | Receptors, Steroid - metabolism | Species Specificity | Humans | Cytochrome P-450 CYP2E1 - genetics | Pharmacology | Receptors, Cytoplasmic and Nuclear - genetics | Cytochrome P-450 CYP2E1 - biosynthesis | Genetic Variation | Transcription Factors - metabolism | Enzyme Induction - genetics | Animals | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Drug Design | Enzyme Induction - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Pharmacokinetics | Cytochrome P-450 CYP2B1 - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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7. Full Text In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes
by Liu, Lu and Sun, Sen and Rui, Hongbing and Li, Xiaohua
Pharmaceutical biology, ISSN 1388-0209, 01/2017, Volume 55, Issue 1, pp. 1868 - 1874
CYP2E1 | CYP3A4 | CYP2D6 | Ampelopsis grossedentata | herb-drug interaction | Drug interaction | herb–drug interaction | Herb | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Plant Sciences | Medical Laboratory Technology | Science & Technology | Binding, Competitive | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Microsomes, Liver - metabolism | Cytochrome P-450 CYP2D6 - chemistry | Antioxidants - pharmacology | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2E1 Inhibitors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cytochrome P-450 CYP3A - metabolism | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A - chemistry | Cytochrome P-450 CYP2D6 - metabolism | Microsomes, Liver - enzymology | Flavonols - pharmacology | Kinetics | Antineoplastic Agents, Phytogenic - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - pharmacology | Cytochrome P-450 CYP2E1 - chemistry | Cytochrome | Enzymes | Flavonoids | Liver | Cytochrome P450 | Isoforms | Enzyme kinetics | Microsomes | CYP2D6 protein | Index Medicus | cyp3a4 | cyp2e1 | ampelopsis grossedentata | cyp2d6
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8. Full Text Structural and functional effects of cytochrome b 5 interactions with human cytochrome P450 enzymes
by Bart, Aaron G and Scott, Emily E
The Journal of biological chemistry, 12/2017, Volume 292, Issue 51, p. 20818
Humans | Cytochrome P-450 CYP2D6 - chemistry | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Cytochromes b5 - chemistry | Cytochromes b5 - metabolism | Cytochrome P-450 CYP3A - genetics | Solutions | Cytochrome P-450 CYP3A - chemistry | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Cytochrome P-450 CYP2E1 - chemistry | Cytochrome P-450 CYP2D6 - genetics | Biocatalysis | Mutagenesis, Site-Directed | Cytochrome P-450 CYP2A6 - genetics | Cytochrome P-450 CYP2A6 - metabolism | Cytochrome P-450 Enzyme System - chemistry | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Protein Conformation | Kinetics | Mutation | Cytochrome P-450 CYP2A6 - chemistry | Amino Acid Substitution
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9. Full Text Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots
by Wang, Yinghao and Wu, Shuisheng and Chen, Zhichun and Zhang, Hua and Zhao, Wanli
Journal of ethnopharmacology, ISSN 0378-8741, 05/2015, Volume 166, pp. 66 - 73
Drug–herb interactions | Enzyme inhibition | Alkaloids | Gelsemium elegans | Cytochrome P450 | Cytochrome | Drug-herb interactions | P450 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Plant Extracts - chemistry | Cytochromes - antagonists & inhibitors | Alkaloids - pharmacology | Plant Extracts - pharmacology | Rats | Gelsemium - chemistry | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2A6 - antagonists & inhibitors | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P-450 CYP3A - metabolism | Microsomes, Liver - drug effects | Plant Roots - chemistry | Cytochrome P-450 CYP1A2 | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Alkaloids - chemistry | Psoriasis | Cytochrome P-450 | Index Medicus
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