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The Journal of Clinical Pharmacology, ISSN 0091-2700, 09/2015, Volume 55, Issue 9, pp. 1012 - 1023
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 6/2014, Volume 70, Issue 6, pp. 675 - 684
ACT-178882, a direct renin inhibitor, was used as a model compound in an elaborate drug–drug interaction study with atorvastatin and simvastatin to explore... 
Biomedicine | ACT-178882 | Induction | Simvastatin | Drug–drug interaction | Atorvastatin | Inhibition | Pharmacology/Toxicology | Drug-drug interaction | DRUG-INTERACTIONS | TESTOSTERONE | ITRACONAZOLE | CLINICAL PHARMACOKINETICS | IN-VITRO | METABOLISM | RELEVANCE | PHARMACOLOGY & PHARMACY | MIDAZOLAM | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Pyrroles - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Heptanoic Acids - pharmacokinetics | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Cyclopropanes - blood | Substrate Specificity | Male | Cyclopropanes - adverse effects | Simvastatin - blood | Cytochrome P-450 CYP3A Inducers - adverse effects | Cytochrome P-450 CYP3A Inducers - blood | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Pyridines - adverse effects | Drug Interactions | Cyclopropanes - administration & dosage | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Cyclopropanes - pharmacology | Cytochrome P-450 CYP3A - biosynthesis | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Pyridines - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - blood | Simvastatin - administration & dosage | Pyrroles - blood | Simvastatin - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - administration & dosage | Pyridines - blood | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A - metabolism | Adolescent | Pyridines - pharmacology | Cytochrome P-450 CYP3A Inhibitors - adverse effects | Heptanoic Acids - blood | Metabolites | Analysis | Cytochrome P-450 | Dosage and administration | Investigations | Antilipemic agents | Hypertension | Clinical trials | Pharmacology | Inhibitor drugs | Statins
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138875 - e0138875
To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction... 
VITRO | COCKTAIL | METABOLISM | DRUG-INTERACTIONS | HUMAN HEPATOCYTES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | INDUCTION | Cytochrome P-450 CYP1A2 Inducers - pharmacology | Cells, Cultured | Male | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Quinolines - pharmacology | Cytochrome P-450 CYP1A2 Inducers - pharmacokinetics | Quinolines - pharmacokinetics | Animals | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP3A Inducers - pharmacokinetics | Enzyme Induction - drug effects | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Kinetics | Hepatocytes - drug effects | Hepatocytes - enzymology | Complications and side effects | Chemotherapy | Cytochrome P-450 | Physiological aspects | Quinoline | Genetic aspects | Dosage and administration | Research | Cancer | Cytochrome | CYP1A protein | Life assessment | mRNA | Cancer therapies | Toxicology | Metabolites | Rodents | Pretreatment | Inducers | Caffeine | Enzymes | Cytochrome P450 | Rats | Pharmacology | Liquid chromatography | FDA approval | Metabolism | Gene expression | High-performance liquid chromatography | Polymerase chain reaction | Studies | Pathology | Hepatocytes | Pharmacy | In vivo methods and tests | Pharmaceuticals | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 10/2015, Volume 84, pp. 99 - 105
Occupational toxicology and clinical pharmacology integration will be useful to understand potential exposure-drug interaction and to shape risk assessment... 
CYP3A | Ethanol fuel | CYP2C | Pharmacokinetics | CYP2D | Inhalation | VITRO | ENANTIOMERS | FOOD SCIENCE & TECHNOLOGY | CYTOCHROME-P450 ISOFORMS | INVERSION | PLASMA | ENZYME | LIQUID-CHROMATOGRAPHY | ORGANIC-SOLVENTS | LIVER | STEREOSELECTIVE METABOLISM | TOXICOLOGY | Limonene Hydroxylases - metabolism | Fluoxetine - pharmacokinetics | Air Pollutants, Occupational - toxicity | Cytochrome P-450 Enzyme Inhibitors - blood | Ethanol - toxicity | Rats, Wistar | Verapamil - blood | Cytochrome P-450 Enzyme System - metabolism | Male | Verapamil - analogs & derivatives | Limonene Hydroxylases - antagonists & inhibitors | Ibuprofen - blood | Cytochrome P-450 CYP3A - chemistry | Enzyme Induction - drug effects | Inhalation Exposure - adverse effects | Biofuels - toxicity | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Ibuprofen - pharmacokinetics | Verapamil - pharmacokinetics | Biomarkers - blood | Toxicity Tests, Chronic - methods | Fluoxetine - blood | Aryl Hydrocarbon Hydroxylases - metabolism | Verapamil - chemistry | Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics | Cytochrome P-450 Enzyme System - chemistry | Animals | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Atmosphere Exposure Chambers | Cytochrome P-450 Enzyme Inhibitors - toxicity | Cytochrome P-450 Enzyme Inducers - toxicity | Alcohol, Denatured | Isoenzymes | Fluoxetine | Cytochrome P-450 | Ibuprofen | Alcohol | Enantiomers
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Cytochrome P450 (CYP) activity can be assessed using a ‘cocktail’ phenotyping approach. Recently, we have developed a cocktail (Geneva cocktail) which combines... 
2D6 | PARAXANTHINE | BUPROPION | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FLURBIPROFEN | METABOLIZING-ENZYMES | COOPERSTOWN 5+1 COCKTAIL | ORAL-CONTRACEPTIVES | P-GLYCOPROTEIN | Caffeine - administration & dosage | Humans | Midazolam - administration & dosage | Male | Genotyping Techniques | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Adult | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cross-Over Studies | Phenotype | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Index Medicus
Journal Article
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 05/2018, Volume 84, Issue 5, pp. 952 - 960
Journal Article