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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6678 - 6692
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers.... 
TARGET | CHEMISTRY, MEDICINAL | PATHWAY | MECHANISMS | BETA-CATENIN | WNT | CANCER | Acyltransferases - antagonists & inhibitors | Maleimides - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Microsomes, Liver - metabolism | Maleimides - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Maleimides - pharmacokinetics | Cytochrome P-450 CYP1A2 Inhibitors - pharmacokinetics | Maleimides - chemical synthesis | HEK293 Cells | Pyridazines - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - pharmacology | Wnt Signaling Pathway | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Rats | Cytochrome P-450 CYP1A2 Inhibitors - chemical synthesis | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - chemical synthesis | Xenograft Model Antitumor Assays | Animals | Cytochrome P-450 CYP1A2 Inhibitors - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - chemical synthesis | High-Throughput Screening Assays | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Cytochrome P-450 CYP1A2 Inhibitors - administration & dosage | Cell Line, Tumor | Pyridazines - pharmacokinetics | Mice, Inbred BALB C
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 7/2018, Volume 74, Issue 7, pp. 913 - 920
Cytochrome P450 (CYP) 3A4 is responsible for the metabolism of more than 30% of clinically used drugs. Inherent between subject variability in clearance of... 
Biomedicine | Inter-racial variability | Caucasian | South Asian | Pharmacology/Toxicology | Pharmacokinetics | Inducibility | Cytochrome P450 3A4 | MESSENGER-RNA EXPRESSION | INTERINDIVIDUAL VARIABILITY | POPULATIONS | POLYMORPHISM | CYTOCHROME-P450 3A4 | GENOTYPE-PHENOTYPE ASSOCIATIONS | METABOLISM | IN-VIVO | PHARMACOLOGY & PHARMACY | MIDAZOLAM | Rifampin - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Rifampin - blood | Area Under Curve | Humans | Asian Continental Ancestry Group - genetics | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Cytochrome P-450 CYP3A Inducers - blood | Clarithromycin - blood | Young Adult | Cytochrome P-450 CYP3A - genetics | Clarithromycin - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - pharmacokinetics | Adult | Continental Population Groups | European Continental Ancestry Group - genetics | Cytochrome P-450 CYP3A Inhibitors - blood | Enzyme Induction | Genotype | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - pharmacology | Midazolam - blood | Cytochrome P-450 CYP3A - metabolism | Rifampin - pharmacology | Clarithromycin - pharmacology | Physiological aspects | Medical colleges | Rifampin | Analysis | Cytochrome P-450 | Cytochrome | Clarithromycin | Statistical analysis | Cytochrome P450 | Variability | Whites | Exposure | Males | Metabolism | Substrates | Midazolam | Genotypes | Asians
Journal Article
Journal Article
Environmental Pollution, ISSN 0269-7491, 03/2017, Volume 222, pp. 504 - 512
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2018, Volume 294, pp. 27 - 36
The high risk of herb-drug interactions (HDIs) mediated by the herbal medicines and dietary supplements which containing abundant flavonoids had become more... 
Herb-drug interactions (HDIs) | Flavonoids | CYP3A4 | QSAR | SOPHORA-TONKINENSIS | ANTIBACTERIAL | RISK | PIE | HERBS | IN-VITRO | INHIBITION | CYTOCHROME-P450 ENZYMES | GRAPEFRUIT JUICE | TOXICOLOGY | PROBE | Anti-Anxiety Agents - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Diazepam - metabolism | Humans | Microsomes, Liver - metabolism | Drugs, Chinese Herbal - pharmacology | Hydroxylation - drug effects | Hepatocytes - metabolism | Drugs, Chinese Herbal - metabolism | Dietary Supplements - analysis | Diazepam - pharmacology | Hepatocytes - cytology | Diazepam - chemistry | Bufanolides - metabolism | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Anti-Anxiety Agents - chemistry | Microsomes, Liver - enzymology | Molecular Structure | Hepatocytes - drug effects | Quantitative Structure-Activity Relationship | Food-Drug Interactions | Cells, Cultured | Computational Biology | Anti-Anxiety Agents - pharmacology | Models, Molecular | Cytochrome P-450 CYP3A Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Drugs, Chinese Herbal - chemistry | Flavonoids - metabolism | Herb-Drug Interactions | Bufanolides - chemistry | Kinetics | Flavonoids - chemistry | Analysis | Drug interactions | Cytochrome P-450 | Dietary supplements | Isoflavones | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 639 - 644
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2018, Volume 58, Issue 2, pp. 180 - 192
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2017, Volume 83, Issue 4, pp. 846 - 854
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 9, pp. 4210 - 4220
Journal Article
Journal Article