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Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
British journal of clinical pharmacology, ISSN 0306-5251, 09/2013, Volume 76, Issue 3, pp. 455 - 466
Aims The anticoagulant rivaroxaban is an oral, direct Factor Xa inhibitor for the management of thromboembolic disorders... 
P‐glycoprotein | rivaroxaban | drug interactions | cytochrome P450 | healthy subjects | P-glycoprotein | Rivaroxaban | Healthy subjects | Cytochrome P450 | Drug interactions | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Anticoagulants - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Erythromycin - pharmacology | Ketoconazole - administration & dosage | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Midazolam - administration & dosage | Substrate Specificity | Metabolic Clearance Rate | Thiophenes - administration & dosage | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Drug Interactions | Enzyme Inhibitors - pharmacokinetics | Clarithromycin - pharmacokinetics | Clarithromycin - administration & dosage | Adult | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Ketoconazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A - administration & dosage | Erythromycin - administration & dosage | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Thiophenes - pharmacokinetics | Erythromycin - pharmacokinetics | Cytochrome P-450 CYP3A - metabolism | Adolescent | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Clarithromycin - pharmacology | Midazolam - pharmacology | Ketoconazole | Protease inhibitors | Fluconazole | Proteases | Cytochrome P-450 | Dosage and administration | Anticoagulants (Medicine) | Erythromycin | Thromboembolism | Index Medicus
Journal Article
Journal Article
Journal Article
1993, Handbook of experimental pharmacology, ISBN 3540559086, Volume 105., xxxiv, 739
Book
PloS one, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0147183 - e0147183
...) or human recombinant CYPs. The results showed that CK inhibited the enzyme activities of CYP2C9 and CYP3A4 in the HLMs... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Drug Screening Assays, Antitumor - methods | Humans | Microsomes, Liver - metabolism | Substrate Specificity | Antineoplastic Agents, Phytogenic - chemistry | Cytochrome P-450 CYP2C9 Inhibitors - chemistry | Ginsenosides - metabolism | Ginsenosides - pharmacology | Recombinant Proteins | Enzyme Activation - drug effects | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP2C9 Inhibitors - pharmacology | Panax - chemistry | Cytochrome P-450 CYP3A - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents, Phytogenic - metabolism | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Kinetics | Antineoplastic Agents, Phytogenic - pharmacology | Ginsenosides - chemistry | In Vitro Techniques | Cytochrome P-450 CYP2C9 - metabolism | Prevention | Physiological aspects | Drug metabolism | Research | Cytochrome P-450 | Cancer | Cytochrome | Drugs | Transplants & implants | Molecular structure | Liver | Enzymatic activity | Metabolites | Hepatology | Pharmaceutical industry | CYP2D6 protein | Enzymes | Cytochrome P450 | Substrate inhibition | Pharmacology | CYP1A2 protein | Metabolism | Medical screening | Substrates | Microsomes | Chromatography | Infectious diseases | Hospitals | Inhibitors | Isoforms | Ginseng | Index Medicus
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 12/2008, Volume 36, Issue 12, pp. 2547 - 2555
.... CYP1A2 is generally considered to be the major enzyme involved in the biotransformation of CLZ to its N -demethylated (norCLZ) and N -oxygenated (CLZ N -oxide... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2C9 | Clozapine - metabolism | Oxidoreductases, N-Demethylating - genetics | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Biotransformation - genetics | Cytochrome P-450 Enzyme System - metabolism | Dextromethorphan - metabolism | Ketoconazole - pharmacology | Oxygenases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 Inhibitors | Testosterone - metabolism | Cytochrome P-450 CYP3A - genetics | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Oxygenases - metabolism | Cytochrome P-450 CYP1A2 - genetics | Catalysis | Oxidoreductases, N-Demethylating - metabolism | Tolbutamide - metabolism | Recombinant Proteins - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Oxidation-Reduction | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Clozapine - analogs & derivatives | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Fluvoxamine - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Alleles | Cytochrome P-450 Enzyme System - genetics | Kinetics | Oxygenases - genetics | Cytochrome P-450 CYP2B6 | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article