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Drug Metabolism and Disposition, ISSN 0090-9556, 04/2003, Volume 31, Issue 4, pp. 421 - 431
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2010, Volume 38, Issue 3, pp. 516 - 525
HepaRG cells possess the unique property to differentiate in vitro and to express various functions of mature hepatocytes, including the major cytochromes P450... 
COCKTAIL | TRANSPORTER | IN-VITRO MODEL | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | INDUCTION | MICROSOMAL-ENZYME INDUCERS | TANDEM MASS-SPECTROMETRY | DRUG-METABOLISM | Phenobarbital - pharmacology | Humans | Cytochrome P-450 Enzyme System - metabolism | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | RNA, Messenger - metabolism | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Glutathione Transferase - genetics | Time Factors | Isoenzymes - metabolism | Membrane Transport Proteins - genetics | Enzyme Induction - drug effects | Membrane Transport Proteins - metabolism | Omeprazole - pharmacology | Cell Differentiation | Xenobiotics - metabolism | Cell Culture Techniques | Hepatocytes - drug effects | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Isoenzymes - genetics | Cells, Cultured | Glutathione Transferase - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Gene Expression Regulation - drug effects | Glutathione Transferase - biosynthesis | Membrane Transport Proteins - biosynthesis | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Rifampin - pharmacology | Isoenzymes - biosynthesis | Glucuronosyltransferase - biosynthesis | Cell Line, Transformed | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Receptors, Cytoplasmic and Nuclear | Life Sciences | Glutathione Transferase | Xenobiotics | Drug Evaluation, Preclinical | Glucuronosyltransferase | Hépatology and Gastroenterology | Isoenzymes | Gene Expression Regulation | Enzyme Induction | Cytochrome P-450 Enzyme System | Omeprazole | Human health and pathology | Phenobarbital | Hepatocytes | Membrane Transport Proteins | RNA, Messenger | Rifampin
Journal Article
Archives of Toxicology, ISSN 0340-5761, 10/2008, Volume 82, Issue 10, pp. 667 - 715
Journal Article
Archives of Toxicology, ISSN 0340-5761, 12/2010, Volume 84, Issue 12, pp. 939 - 946
Age-related changes in hepatic expression and activity of cytochrome P450 (CYP) were investigated in male rats aged 3 (weanling), 12 (young), 26 (adult), and... 
Development and aging | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Liver | Drug-metabolizing enzyme | Pharmacology/Toxicology | Expression and activity | Biomedicine general | PROTEIN | DEPENDENT EXPRESSION | TRANSPORTERS | HEPATOCYTE GROWTH-FACTOR | INDUCIBILITY | INDUCTION | DRUG-METABOLIZING-ENZYMES | MESSENGER-RNA | GENE-EXPRESSION | TOXICOLOGY | LIVER-MICROSOMES | Aryl Hydrocarbon Hydroxylases - biosynthesis | Liver - enzymology | Cytochrome P-450 CYP3A | Cytochrome P-450 Enzyme System - metabolism | Male | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | Cytochrome P-450 CYP2E1 - biosynthesis | Cytochrome P450 Family 2 | Isoenzymes - metabolism | Cytochrome P-450 CYP2B1 - metabolism | Membrane Proteins - metabolism | Microsomes, Liver - enzymology | Cytochrome P-450 CYP2B1 - biosynthesis | Rats | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Membrane Proteins - biosynthesis | Animals | Aging - physiology | Cytochrome P-450 CYP1A2 - biosynthesis | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 CYP1A1 - biosynthesis | Isoenzymes - biosynthesis | Steroid 16-alpha-Hydroxylase - biosynthesis | Cytochrome b | Xenobiotics | Pharmacy | Cytochrome P-450 | Proteins | Toxicology | Rodents | Age differences
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 03/2007, Volume 81, Issue 3, pp. 362 - 370
Journal Article
Journal Article