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Veterinary Clinics of North America - Small Animal Practice, ISSN 0195-5616, 09/2013, Volume 43, Issue 5, pp. 1027 - 1038
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 27, pp. 11115 - 11120
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear. Here, we show that the... 
Bone resorption | Enzymes | Cell lines | Stem cells | Bones | Osteoclasts | Cultured cells | Bone marrow cells | Cigarette smoking | Aryl hydrocarbon receptors | Osteoblast | Skeletal remodeling | Toxicology | Bone formation | toxicology | TARGET | RESORPTION | MULTIDISCIPLINARY SCIENCES | osteoblast | AHR | skeletal remodeling | CANCER | IN-VITRO | INHIBITION | METABOLISM | bone formation | CIGARETTE-SMOKE | HEALTH | OSTEOCLAST DIFFERENTIATION | Smoking - adverse effects | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Aryl Hydrocarbon Hydroxylases - biosynthesis | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP1A2 - deficiency | Bone Resorption - metabolism | Female | Cytochrome P-450 CYP1A1 - deficiency | Disease Models, Animal | Bone Resorption - etiology | Benzo(a)pyrene - toxicity | Smoke - adverse effects | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Smoking - genetics | Receptors, Aryl Hydrocarbon - physiology | Tobacco - toxicity | Mice, Knockout | Enzyme Induction - genetics | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Cytochrome P-450 CYP1A2 - biosynthesis | Bone Resorption - pathology | Cytochrome P-450 CYP1B1 | Polychlorinated Dibenzodioxins - toxicity | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Osteoporosis | Carcinogens | Cocarcinogens | Hydrocarbons | Physiological aspects | Health aspects | Smoking | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 2016, Volume 11, Issue 7, p. e0159552
Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the... 
RAT | MULTIDISCIPLINARY SCIENCES | MOUSE | GENES | LIVER | ALPHA | MICE | EXPRESSION | MIDAZOLAM | Liver - enzymology | Metoprolol - pharmacology | Receptors, Cytoplasmic and Nuclear - deficiency | Omeprazole - blood | Cytochrome P-450 Enzyme System - metabolism | Warfarin - pharmacology | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Caffeine - pharmacology | Cytochrome P450 Family 2 - genetics | Female | Omeprazole - pharmacology | Membrane Proteins - metabolism | Metoprolol - blood | Fasting | Membrane Proteins - genetics | Caffeine - blood | Mice, Inbred C57BL | Gene Expression Regulation | Receptors, Cytoplasmic and Nuclear - genetics | Cytochrome P-450 CYP1A2 - metabolism | Mice, Knockout | Animals | Cytochrome P450 Family 2 - metabolism | Midazolam - blood | Cytochrome P-450 CYP3A - metabolism | Warfarin - blood | Cytochrome P-450 Enzyme System - genetics | Inactivation, Metabolic - genetics | Mice | Midazolam - pharmacology | Omeprazole | RNA | Analysis | Cytochrome P-450 | Drug metabolism | Dosage and administration | Research | Health aspects | Receptor analysis | Cytochrome | Drugs | Enzymes | Warfarin | Metoprolol | Liver | Cytochrome P450 | Homology | CYP1A2 protein | Metabolism | Gene expression | Alterations | Analgesics | Rodents | Pharmacy | Midazolam | CYP2D6 protein | Nutritional status | Caffeine
Journal Article
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, ISSN 0962-8436, 02/2013, Volume 368, Issue 1612, p. 20120431
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2009, Volume 37, Issue 12, pp. 2305 - 2313
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2013, Volume 132, Issue 10, pp. 2439 - 2447
Paclitaxel is avidly transported by P‐glycoprotein (P‐gp/MDR1/ABCB1). This results in low oral bioavailability, which can be boosted by coadministration of... 
P‐glycoprotein (P‐gp/MDR1) | paclitaxel | CYP3A4 | oral bioavailability | ritonavir | P-glycoprotein (P-gp/MDR1) | PLUS CYCLOSPORINE | GUT WALL | PHASE-II | KNOCKOUT MICE | CANCER | MDR1 | INHIBITION | METABOLISM | ONCOLOGY | SYSTEMIC EXPOSURE | ABSORPTION | P-glycoprotein (P-gp | Cytochrome P-450 Enzyme Inhibitors | Area Under Curve | Humans | Cytochrome P-450 Enzyme System - metabolism | Biological Availability | Male | Paclitaxel - pharmacokinetics | Intestinal Absorption | Enzyme Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Ritonavir - therapeutic use | Ritonavir - pharmacology | Paclitaxel - blood | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Taxoids - blood | Antineoplastic Agents, Phytogenic - blood | Ritonavir - administration & dosage | Administration, Oral | Docetaxel | Enzyme Inhibitors - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - deficiency | Enzyme Inhibitors - therapeutic use | ATP Binding Cassette Transporter, Subfamily B | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Mice, Knockout | Taxoids - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Taxoids - administration & dosage | Cytochrome P-450 Enzyme System - deficiency | Animals | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 Enzyme System - genetics | Mice | Infusions, Intravenous | Chemotherapy | Glycoproteins | Bioavailability | Rodents
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2007, Volume 35, Issue 7, pp. 1223 - 1231
Journal Article
Journal Article