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Journal Article
Xenobiotica, ISSN 1366-5928, 2008, Volume 30, Issue 12, pp. 1131 - 1152
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2018, Volume 13, pp. 8561 - 8575
...) enzymes, namely, CYP1A2, CYP2D6 and CYP3A4, expressed in the liver. Methods: Dose-dependent effect of the DN, GO and GN nanostructures on the catalytic activity of CYPs was examined using microsome-based model... 
Nanoparticles | Carbon nanostructures | Cytochrome p450 | Liver | Microsomes | liver | POLYCYCLIC AROMATIC-HYDROCARBONS | NANOMATERIALS | NANOSCIENCE & NANOTECHNOLOGY | TOXICITY | carbon nanostructures | cytochrome P450 | INDUCTION | DRUG-METABOLIZING-ENZYMES | WALLED CARBON NANOTUBES | nanoparticles | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOCHROME-P450 ENZYME | microsomes | Cytochrome P-450 CYP2D6 - genetics | Nanostructures - ultrastructure | Cytochrome P-450 Enzyme Inhibitors | Cell Survival | Humans | Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Fluorescence | Hydrodynamics | Hepatocytes - metabolism | Diamond - chemistry | Cytochrome P-450 CYP1A2 - metabolism | Down-Regulation - genetics | Hep G2 Cells | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Nanostructures - chemistry | Graphite - chemistry | Cytochrome P-450 Enzyme System - pharmacology | Hepatocytes - drug effects | Diamond crystals | RNA | Isoenzymes | Graphene | Genes | Cytochrome P-450 | Diamonds | Graphite | Genetic research | Genetic aspects | Gene expression | Cytochrome | Enzymes | Drug delivery systems | Nanomaterials | Metabolism | Carbon | Drug dosages
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93261
Intratumoral expression of genes encoding Cytochrome P450 enzymes (CYP) might play a critical role not only in cancer development but also in the metabolism of anticancer drugs... 
CYP3A4/5 | CYP2W1 | METABOLISM | CANCER | MULTIDISCIPLINARY SCIENCES | CHILDREN | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Prospective Studies | Follow-Up Studies | Humans | Rhabdomyosarcoma - metabolism | Gene Expression Regulation, Neoplastic | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Infant | Male | Muscle, Skeletal - metabolism | Cytochrome P-450 CYP2E1 - genetics | Gene Expression Profiling | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P450 Family 2 | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Biomarkers, Tumor - metabolism | Female | Child | Real-Time Polymerase Chain Reaction | RNA, Messenger - genetics | Cytochrome P-450 CYP1A1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | Gene Expression Regulation, Enzymologic | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 Enzyme System - genetics | Biomarkers, Tumor - genetics | Rhabdomyosarcoma - genetics | Cytochrome | Drugs | Rhabdomyosarcoma | Chemoresistance | Families & family life | Drug development | Tissues | Cancer therapies | Antitumor agents | Rodents | Drug metabolism | Children | Enzymes | Prodrugs | Cytochrome P450 | CYP gene | CYP1A2 protein | Metabolism | Gene expression | Chemical compounds | Patients | Polymerase chain reaction | Musculoskeletal system | Chemotherapy | Tumors | Cancer
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2010, Volume 38, Issue 1, pp. 92 - 99
.... CYP1A2, CYP2B6, and CYP2C19 catalyzed this reaction. In the same system using 2-oxo-clopidogrel as the substrate, detection of the active metabolite of clopidogrel required the addition of glutathione to the system... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | PHARMACOKINETICS | TICLOPIDINE | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 360, Issue 4, pp. 354 - 362
The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel... 
VARIABILITY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | PHARMACOKINETICS | STENT THROMBOSIS | INCREASED RISK | PLATELET INHIBITION | PRASUGREL | PHARMACODYNAMICS | INDIVIDUAL RESPONSIVENESS | ATHEROTHROMBOTIC EVENTS | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Area Under Curve | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Cardiovascular Diseases - genetics | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Genotype | Thrombosis - epidemiology | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Heterozygote | Thrombosis - genetics | Mutation | Usage | Genetic variation | Cytochrome P-450 | Physiological aspects | Causes of | Clopidogrel | Cardiovascular diseases | Health aspects | Risk factors | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 01/2016, Volume 40, Issue 1, pp. 73 - 82
...)‐mediated pathway in U937 monocytic cells. U937 cells are derived from blood monocytes and are considered as the model system for HIV‐related study... 
Cytochrome P450s | Darunavir/Ritonavir | Ethanol | Oxidative Stress | Antioxidant Enzymes | Oxidative stress | Antioxidant enzymes | DENDRITIC CELLS | MACROPHAGES | SUBSTANCE ABUSE | PROTEASE INHIBITORS | NICOTINE METABOLITES | HIV | ALCOHOL | LC-MS/MS METHOD | CONCURRENT DETERMINATION | DRUG-DRUG INTERACTIONS | RITONAVIR | Catalase - drug effects | Superoxide Dismutase - genetics | Antioxidants - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | Monocytes - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Peroxiredoxin VI - genetics | Central Nervous System Depressants - pharmacology | HIV Protease Inhibitors - pharmacology | Peroxiredoxin VI - metabolism | Darunavir - pharmacology | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP2E1 - drug effects | Ritonavir - pharmacology | Cytochrome P-450 CYP3A - drug effects | Superoxide Dismutase - metabolism | RNA, Messenger - drug effects | Cell Line | Cell Survival - drug effects | Catalase - genetics | Oxidative Stress - genetics | Peroxiredoxin VI - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Superoxide Dismutase - drug effects | Blotting, Western | Catalase - metabolism | Monocytes - drug effects | Cytochrome P-450 Enzyme System - drug effects | Ethanol - pharmacology | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 Enzyme System - genetics | Oxidative Stress - drug effects | Superoxide Dismutase-1 | Antioxidants | Antiviral agents | Alcohol, Denatured | RNA | Analysis | Cytochrome P-450 | Physiological aspects | HIV patients | Alcohol | darunavir | antioxidant enzymes | cytochrome P450s | oxidative stress | ritonavir
Journal Article
Archives of toxicology, ISSN 1432-0738, 2014, Volume 90, Issue 2, pp. 291 - 304
The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role... 
Benzo[ a ]pyrene | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Carcinogen metabolism | DNA adducts | Pharmacology/Toxicology | Tumour suppressor p53 | Biomedicine general | Benzo[a]pyrene | DNA-ADDUCTS | METABOLIC-ACTIVATION | HUMAN CANCER-CELLS | P53 | RESPONSES | ARISTOLOCHIC ACID I | MESSENGER-RNA | MICE | TOXICOLOGY | EXPRESSION | BENZO(A)PYRENE | DNA Damage - drug effects | Cell Survival - drug effects | Cytochrome P-450 CYP1B1 - genetics | Inactivation, Metabolic | Polycyclic Aromatic Hydrocarbons - pharmacokinetics | Benzo(a)pyrene - toxicity | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Tumor Suppressor Protein p53 - metabolism | Cytochrome P-450 CYP1B1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Cytochrome P-450 CYP1A1 - metabolism | HCT116 Cells - drug effects | Tumor Suppressor Protein p53 - genetics | Carcinogens - toxicity | DNA Adducts | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cytochrome P-450 Enzyme Inducers - poisoning | DNA Damage - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 Enzyme Inducers - pharmacology | Toxicity Tests | Cytochrome P-450 Enzyme Inducers - toxicity | Metabolites | Benzopyrene | Analysis | Cytochrome P-450 | Physiological aspects | Tumor proteins | Xenobiotics | Cells | Cytochrome | Carcinogens | Polycyclic aromatic hydrocarbons | Tumors | Index Medicus | Toxicokinetics and Metabolism | Cell Survival | HCT116 Cells | Polycyclic Aromatic Hydrocarbons | Benzo(a)pyrene | NAD(P)H Dehydrogenase (Quinone) | Journal Article | Cytochrome P-450 Enzyme Inducers | Tumor Suppressor Protein p53 | Research Support, Non-U.S. Gov't | Cytochrome P-450 CYP1B1 | Cytochrome P-450 CYP1A1 | DNA Damage | Receptors, Aryl Hydrocarbon | Basic Helix-Loop-Helix Transcription Factors
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 12/2006, Volume 6, Issue 12, pp. 947 - 960
Some cytochrome P450 (CYP) heme-thiolate enzymes participate in the detoxication and, paradoxically, the formation of reactive intermediates of thousands of chemicals that can damage DNA, as well as lipids and proteins... 
LUNG-CANCER | AROMATIC-HYDROCARBON RECEPTOR | MEDIATED INDUCTION | CIGARETTE-SMOKING | IMMUNE-SYSTEM | GENETIC POLYMORPHISMS | ONCOLOGY | BREAST-CANCER RISK | CHEMICAL CARCINOGENESIS | NUCLEAR RECEPTORS | DRUG-METABOLIZING-ENZYMES | Humans | Cytochrome P-450 Enzyme System - metabolism | Carcinogens, Environmental - toxicity | DNA-Binding Proteins - metabolism | Neoplasms - chemically induced | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Isoenzymes - metabolism | Biotransformation | Receptors, Aryl Hydrocarbon - metabolism | Carcinogens, Environmental - pharmacokinetics | Pharmacogenetics | Risk Assessment | Signal Transduction | Isoenzymes - genetics | Risk Factors | Neoplasms - enzymology | Cytochrome P-450 CYP1A1 - metabolism | Cell Transformation, Neoplastic - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Metabolic Networks and Pathways | Models, Biological | Cytochrome P-450 CYP1B1 | Cytochrome P-450 Enzyme System - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Cytochrome P-450 | Cancer
Journal Article