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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2017, Volume 102, Issue 3, pp. 397 - 404
Journal Article
Gut, ISSN 0017-5749, 07/2016, Volume 65, Issue 7, pp. 1202 - 1214
ObjectivePeroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role... 
LIPID-METABOLISM | INSULIN-RESISTANCE | ACTIVATED RECEPTOR-ALPHA | NONALCOHOLIC STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | ADAPTIVE RESPONSE | EXPRESSION | GROWTH-FACTOR 21 | ADIPOSE-TISSUE | FGF21 | Drugs | Fibroblast growth factor | Animal models | Fasting | Body weight | Homeostasis | GENE EXPRESSION | Adipocytes | Nuclear receptors | Metabolism | Fatty acids | Lipolysis | Diets | Fenofibrate | Fatty liver | Hepatocytes | Aging | Lipid metabolism | steatosis | Digestive tract | Hypothermia | Gene Expression - drug effects | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - biosynthesis | Gene Expression Profiling | RNA, Messenger - metabolism | Lipolysis - genetics | Fenofibrate - pharmacology | Lipid Metabolism - genetics | Fatty Acids - metabolism | Disease Models, Animal | Hypoglycemia - genetics | Non-alcoholic Fatty Liver Disease - genetics | Mice, Inbred C57BL | Overweight - genetics | PPAR alpha - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Hypolipidemic Agents - pharmacology | Mice, Knockout | Triglycerides - metabolism | Animals | Aging - physiology | Cytochrome P-450 Enzyme System - genetics | PPAR alpha - metabolism | Homeostasis - genetics | Hypothermia - genetics | Cytochrome P450 Family 4 - genetics | Genetically modified mice | Peroxisomes | Research | Liver cells | Index Medicus | Abridged Index Medicus | Life Sciences | Animal biology | Toxicology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. 3181 - 3185
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 08/2016, Volume 119, Issue 2, pp. 173 - 183
Sunitinib ( SUN ) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To... 
BREAST-CANCER | DIACYLGLYCEROL ACYLTRANSFERASE | TYROSINE KINASE INHIBITOR | RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | CYTOCHROME-P450 3A4 | DRUG TRANSPORT | PHASE-I | RENAL-CELL CARCINOMA | HEPATITIS-E | Proteins | Enzymes | Protein expression | Rodents | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Rats, Wistar | Liver | Pyrroles | Transcriptome | Male | Steroid 16-alpha-Hydroxylase | Kidney | Cytochrome P450 Family 2 | Cytochrome P-450 CYP2E1 | Cytochrome P450 Family 4 | Cyp1a2 protein, rat | Cytochrome P-450 CYP1A2 | NQO1 protein, rat | Cytochrome P-450 CYP1A1 | Glutathione Transferase | Indoles | Xenobiotics | Glucuronosyltransferase | sunitinib | Isoenzymes | glutathione S-transferase alpha | Rats | NAD(P)H Dehydrogenase (Quinone) | Cytochrome P-450 Enzyme System | Ugt1a1 protein, rat | Index Medicus | cytochrome P-450 CYP4A2 (rat) | ATP-Binding Cassette Transporters | Animals | Cyp1b1 protein, rat | Abcg2 protein, rat | Cytochrome P-450 CYP1B1 | Abcc2 protein, rat | Lipid Peroxidation | Aryl Hydrocarbon Hydroxylases | RNA, Messenger | Cyp4f4 protein, rat | CYP2C11 protein, rat | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Liver - enzymology | Kidney - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Cytochrome P450 Family 2 - genetics | Indoles - pharmacology | Xenobiotics - metabolism | Steroid 16-alpha-Hydroxylase - antagonists & inhibitors | Cytochrome P450 Family 2 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Kidney - drug effects | Isoenzymes - genetics | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Cytochrome P450 Family 4 - metabolism | Pyrroles - pharmacology | Cytochrome P450 Family 2 - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Cytochrome P450 Family 4 - genetics | Antimitotic agents | Antineoplastic agents
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2017, Volume 146, pp. 174 - 187
We have established a protocol for the preparation of permeabilized fission yeast cells (enzyme bags) that recombinantly express human cytochrome P450 enzymes... 
Ether cleavage | Fission yeast | Hydroxylation | Human cytochrome P450 | Biotransformation | CYTOCHROME-P450 | 3A4 CATALYTIC-ACTIVITIES | ACID | BREAST-CANCER | SELECTIVE INHIBITOR | ENZYME | STRUCTURAL BASIS | PHARMACOLOGY & PHARMACY | GENE-THERAPY | EXPRESSION | DRUG-METABOLISM | Cytochrome P-450 CYP2C9 | Enzyme Inhibitors | Cytochrome P-450 CYP3A | Humans | Arachidonic acid (PubChem CID: 444899) | Gene Expression Regulation, Neoplastic | 1-Benzylimidazole (PubChem CID: 77918) | Substrate Specificity | Myristic acid (PubChem CID: 11005) | CYP4Z1 protein, human | Breast Neoplasms | Miconazole (PubChem CID: 4189) | CYP2C9 protein, human | Cytochrome P450 Family 4 | Octoxynol | Female | Binding Sites | Schizosaccharomyces | Lauric acid (PubChem CID: 3893) | Models, Molecular | Permeability | Tolazoline (PubChem CID: 5504) | Index Medicus | Gene Expression Regulation, Enzymologic | Testosterone | Econazole (PubChem CID: 3198) | Aminobenzotriazole (PubChem CID: 1367) | CYP3A4 protein, human | Eicosadienoic acid (PubChem CID: 6439848) | Protein Conformation | Microsomes, Liver | Breast Neoplasms - metabolism | Schizosaccharomyces - genetics | Breast Neoplasms - enzymology | Microsomes, Liver - drug effects | Microsomes, Liver - enzymology | Cytochrome P-450 CYP2C9 - metabolism | Enzyme Inhibitors - pharmacology | Cytochrome P450 Family 4 - metabolism | Schizosaccharomyces - metabolism | Breast Neoplasms - genetics | Cytochrome P-450 CYP3A - metabolism | Octoxynol - pharmacology | Cytochrome P450 Family 4 - antagonists & inhibitors | Cytochrome P450 Family 4 - genetics | Hydrogen | Analysis | Luciferase | Cytochrome P-450 | Cellulose | Crystals | Medical tests | Metastasis | Structure
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 05/2016, Volume 427, Issue C, pp. 133 - 142
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2017, Volume 330, pp. 100 - 106
Because macrophages respond to a variety of pathological and pharmacological reagents, understanding the role of P450s in macrophages is important for... 
THP1 | CYP | Fatty acid metabolism | PPAR gamma | CYP4V2 | Macrophage | CYTOCHROME-P450 | MESSENGER-RNA EXPRESSION | PROSTAGLANDIN-H | BLOOD MONONUCLEAR-CELLS | BRONCHOALVEOLAR MACROPHAGES | GENE | METABOLISM | MONOCYTE-DERIVED MACROPHAGES | PPAR-GAMMA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INFLAMMATORY MEDIATORS | Tetradecanoylphorbol Acetate | 12-hydroxydodecanoic acid | Fatty Acids | Humans | PPAR alpha | Macrophages | Anilides | Lauric Acids | Liver X Receptors | Cytochrome P450 Family 4 | Transcription, Genetic | CYP4V2 protein, human | lauric acid | Cell Line | Index Medicus | Gene Expression Regulation, Enzymologic | Hydroxycholesterols | RNA, Small Interfering | 22-hydroxycholesterol | 2-chloro-5-nitrobenzanilide | RNA, Messenger | PPAR alpha - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | RNA, Small Interfering - genetics | PPAR alpha - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Liver X Receptors - antagonists & inhibitors | RNA, Messenger - genetics | PPAR alpha - genetics | Lauric Acids - metabolism | Cytochrome P450 Family 4 - biosynthesis | Hydroxycholesterols - pharmacology | Macrophages - enzymology | RNA, Messenger - biosynthesis | Anilides - pharmacology | Macrophages - drug effects | Fatty Acids - metabolism | Cytochrome P450 Family 4 - genetics | Metabolites | RNA | Atherosclerosis | Cytochrome P-450 | Genetic aspects | Genetic transcription | Fatty acids | Medical colleges | Pharmacogenetics | Liver | Physiological aspects | DNA polymerases
Journal Article
Experimental Physiology, ISSN 0958-0670, 12/2017, Volume 102, Issue 12, pp. 1596 - 1606
New FindingsWhat is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation... 
diabetes mellitus | brain ischemia | hyperbaric oxygenation | stroke | THERAPEUTIC WINDOW | 20-HETE | PHYSIOLOGY | GUIDELINES | MODEL | HEALTH-CARE PROFESSIONALS | INFARCT VOLUME | CEREBRAL-ARTERY OCCLUSION | ISCHEMIC-STROKE | ASSOCIATION | BRAIN | Cytochrome | Stroke | Streptozocin | Cytochrome P450 | Diabetes mellitus | Cortex | Acid production | Gene expression | Epoxide hydrolase | Nitric-oxide synthase | Reperfusion | Acids | Ischemia | Metabolites | Cerebral blood flow | Nitric oxide | Rodents | Diabetes | Oxygenation | Infarction, Middle Cerebral Artery - physiopathology | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Diabetes Mellitus, Type 1 - metabolism | Infarction, Middle Cerebral Artery - therapy | Steroid 16-alpha-Hydroxylase - metabolism | Infarction, Middle Cerebral Artery - metabolism | RNA, Messenger - metabolism | Diabetes Mellitus, Type 1 - therapy | Diabetes Mellitus, Experimental - therapy | Brain - metabolism | Neuroprotective Agents - pharmacology | Time Factors | Cytochrome P450 Family 2 - genetics | Female | Nitric Oxide Synthase Type III - metabolism | Diabetes Mellitus, Experimental - metabolism | Reperfusion Injury - metabolism | Diabetes Mellitus, Experimental - physiopathology | Reperfusion Injury - pathology | Diabetes Mellitus, Type 1 - physiopathology | RNA, Messenger - genetics | Combined Modality Therapy | Infarction, Middle Cerebral Artery - pathology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Epoxide Hydrolases - genetics | Brain - drug effects | Gene Expression Regulation, Enzymologic | Cytochrome P450 Family 4 - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Reperfusion Injury - prevention & control | Cytochrome P450 Family 2 - metabolism | Reperfusion Injury - physiopathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Steroid 16-alpha-Hydroxylase - genetics | Amidines - pharmacology | Epoxide Hydrolases - metabolism | Hyperbaric Oxygenation | Cytochrome P450 Family 4 - genetics | Stroke (Disease) | RNA | Type 1 diabetes | Cytochrome P-450 | Index Medicus
Journal Article