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Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 08/2016, Volume 119, Issue 2, pp. 173 - 183
Sunitinib ( SUN ) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To... 
BREAST-CANCER | DIACYLGLYCEROL ACYLTRANSFERASE | TYROSINE KINASE INHIBITOR | RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | CYTOCHROME-P450 3A4 | DRUG TRANSPORT | PHASE-I | RENAL-CELL CARCINOMA | HEPATITIS-E | Proteins | Enzymes | Protein expression | Rodents | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Rats, Wistar | Liver | Pyrroles | Transcriptome | Male | Steroid 16-alpha-Hydroxylase | Kidney | Cytochrome P450 Family 2 | Cytochrome P-450 CYP2E1 | Cytochrome P450 Family 4 | Cyp1a2 protein, rat | Cytochrome P-450 CYP1A2 | NQO1 protein, rat | Cytochrome P-450 CYP1A1 | Glutathione Transferase | Indoles | Xenobiotics | Glucuronosyltransferase | sunitinib | Isoenzymes | glutathione S-transferase alpha | Rats | NAD(P)H Dehydrogenase (Quinone) | Cytochrome P-450 Enzyme System | Ugt1a1 protein, rat | Index Medicus | cytochrome P-450 CYP4A2 (rat) | ATP-Binding Cassette Transporters | Animals | Cyp1b1 protein, rat | Abcg2 protein, rat | Cytochrome P-450 CYP1B1 | Abcc2 protein, rat | Lipid Peroxidation | Aryl Hydrocarbon Hydroxylases | RNA, Messenger | Cyp4f4 protein, rat | CYP2C11 protein, rat | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Liver - enzymology | Kidney - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Cytochrome P450 Family 2 - genetics | Indoles - pharmacology | Xenobiotics - metabolism | Steroid 16-alpha-Hydroxylase - antagonists & inhibitors | Cytochrome P450 Family 2 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Kidney - drug effects | Isoenzymes - genetics | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Cytochrome P450 Family 4 - metabolism | Pyrroles - pharmacology | Cytochrome P450 Family 2 - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Cytochrome P450 Family 4 - genetics | Antimitotic agents | Antineoplastic agents
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2017, Volume 146, pp. 174 - 187
We have established a protocol for the preparation of permeabilized fission yeast cells (enzyme bags) that recombinantly express human cytochrome P450 enzymes... 
Ether cleavage | Fission yeast | Hydroxylation | Human cytochrome P450 | Biotransformation | CYTOCHROME-P450 | 3A4 CATALYTIC-ACTIVITIES | ACID | BREAST-CANCER | SELECTIVE INHIBITOR | ENZYME | STRUCTURAL BASIS | PHARMACOLOGY & PHARMACY | GENE-THERAPY | EXPRESSION | DRUG-METABOLISM | Cytochrome P-450 CYP2C9 | Enzyme Inhibitors | Cytochrome P-450 CYP3A | Humans | Arachidonic acid (PubChem CID: 444899) | Gene Expression Regulation, Neoplastic | 1-Benzylimidazole (PubChem CID: 77918) | Substrate Specificity | Myristic acid (PubChem CID: 11005) | CYP4Z1 protein, human | Breast Neoplasms | Miconazole (PubChem CID: 4189) | CYP2C9 protein, human | Cytochrome P450 Family 4 | Octoxynol | Female | Binding Sites | Schizosaccharomyces | Lauric acid (PubChem CID: 3893) | Models, Molecular | Permeability | Tolazoline (PubChem CID: 5504) | Index Medicus | Gene Expression Regulation, Enzymologic | Testosterone | Econazole (PubChem CID: 3198) | Aminobenzotriazole (PubChem CID: 1367) | CYP3A4 protein, human | Eicosadienoic acid (PubChem CID: 6439848) | Protein Conformation | Microsomes, Liver | Breast Neoplasms - metabolism | Schizosaccharomyces - genetics | Breast Neoplasms - enzymology | Microsomes, Liver - drug effects | Microsomes, Liver - enzymology | Cytochrome P-450 CYP2C9 - metabolism | Enzyme Inhibitors - pharmacology | Cytochrome P450 Family 4 - metabolism | Schizosaccharomyces - metabolism | Breast Neoplasms - genetics | Cytochrome P-450 CYP3A - metabolism | Octoxynol - pharmacology | Cytochrome P450 Family 4 - antagonists & inhibitors | Cytochrome P450 Family 4 - genetics | Hydrogen | Analysis | Luciferase | Cytochrome P-450 | Cellulose | Crystals | Medical tests | Metastasis | Structure
Journal Article
Journal Article
Experimental Physiology, ISSN 0958-0670, 12/2017, Volume 102, Issue 12, pp. 1596 - 1606
New FindingsWhat is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation... 
diabetes mellitus | brain ischemia | hyperbaric oxygenation | stroke | THERAPEUTIC WINDOW | 20-HETE | PHYSIOLOGY | GUIDELINES | MODEL | HEALTH-CARE PROFESSIONALS | INFARCT VOLUME | CEREBRAL-ARTERY OCCLUSION | ISCHEMIC-STROKE | ASSOCIATION | BRAIN | Cytochrome | Stroke | Streptozocin | Cytochrome P450 | Diabetes mellitus | Cortex | Acid production | Gene expression | Epoxide hydrolase | Nitric-oxide synthase | Reperfusion | Acids | Ischemia | Metabolites | Cerebral blood flow | Nitric oxide | Rodents | Diabetes | Oxygenation | Infarction, Middle Cerebral Artery - physiopathology | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Diabetes Mellitus, Type 1 - metabolism | Infarction, Middle Cerebral Artery - therapy | Steroid 16-alpha-Hydroxylase - metabolism | Infarction, Middle Cerebral Artery - metabolism | RNA, Messenger - metabolism | Diabetes Mellitus, Type 1 - therapy | Diabetes Mellitus, Experimental - therapy | Brain - metabolism | Neuroprotective Agents - pharmacology | Time Factors | Cytochrome P450 Family 2 - genetics | Female | Nitric Oxide Synthase Type III - metabolism | Diabetes Mellitus, Experimental - metabolism | Reperfusion Injury - metabolism | Diabetes Mellitus, Experimental - physiopathology | Reperfusion Injury - pathology | Diabetes Mellitus, Type 1 - physiopathology | RNA, Messenger - genetics | Combined Modality Therapy | Infarction, Middle Cerebral Artery - pathology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Epoxide Hydrolases - genetics | Brain - drug effects | Gene Expression Regulation, Enzymologic | Cytochrome P450 Family 4 - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Reperfusion Injury - prevention & control | Cytochrome P450 Family 2 - metabolism | Reperfusion Injury - physiopathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Steroid 16-alpha-Hydroxylase - genetics | Amidines - pharmacology | Epoxide Hydrolases - metabolism | Hyperbaric Oxygenation | Cytochrome P450 Family 4 - genetics | Stroke (Disease) | RNA | Type 1 diabetes | Cytochrome P-450 | Index Medicus
Journal Article
Journal Article
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 09/2017, Volume 47, pp. 120 - 131
Journal Article
Inflammation, ISSN 0360-3997, 2/2018, Volume 41, Issue 1, pp. 337 - 355
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that can activate or inhibit the expression of many target genes by forming a... 
bexarotene | Pathology | Medicine & Public Health | inflammation | Rheumatology | PPARα/β/γ-RXRα | Internal Medicine | iNOS | CYP4F6 | Pharmacology/Toxicology | lipopolysaccharide | 20-HETE | OXIDATIVE STRESS | 5,14-HEDGE | VASOACTIVE EICOSANOIDS | 20-HYDROXYEICOSATETRAENOIC ACID | ENDOTOXIN-INDUCED HYPOTENSION | IMMUNOLOGY | RECEPTOR-ALPHA | CELL BIOLOGY | NITRIC-OXIDE PRODUCTION | PATHWAY | PPAR alpha/beta/gamma-RXR alpha | CYTOCHROME-P450 4A ACTIVITY | Liver | Lipopolysaccharides | Rodents | Peroxidase | Blood pressure | Heart diseases | Endotoxemia | Kidneys | Cytochrome P450 | Septic shock | Retinoid X receptors | Gene expression | Nuclear receptors | Hypotension | L-Lactate dehydrogenase | Nitric-oxide synthase | Heart rate | Tachycardia | Nitric oxide | Dimethyl sulfoxide | Sepsis | Lactic acid | Peroxisome proliferator-activated receptors | Inflammation - chemically induced | Retinoid X Receptor alpha - metabolism | Rats, Wistar | Multiprotein Complexes | Male | Shock, Septic - metabolism | Heart Rate - drug effects | Inflammation - metabolism | Kidney - metabolism | Hypotension - physiopathology | Liver - drug effects | Inflammation - drug therapy | Myocardium - metabolism | Arterial Pressure - drug effects | Shock, Septic - drug therapy | Hypotension - prevention & control | Lung - metabolism | Disease Models, Animal | Kidney - drug effects | Shock, Septic - chemically induced | Liver - metabolism | Shock, Septic - physiopathology | Hypotension - chemically induced | Leukotriene B4 - blood | Retinoid X Receptor alpha - agonists | Cytochrome P450 Family 4 - metabolism | Animals | Hypotension - metabolism | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | L-Lactate Dehydrogenase - blood | Tetrahydronaphthalenes - pharmacology | Lung - drug effects | Peroxisome Proliferator-Activated Receptors - metabolism | Peroxidase - blood | Cytochrome P450 Family 4 - genetics | Inflammation - physiopathology | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal Article