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1993, Handbook of experimental pharmacology, ISBN 3540559086, Volume 105., xxxiv, 739
Book
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9384 - 9389
Some bacterial species are able to utilize extracellular mineral forms of iron and manganese as respiratory electron acceptors. In Shewanella oneidensis this... 
Electrodes | Solvents | Electronic structure | Electron transfer | Cytochromes | Ligands | Minerals | Shewanella | Electrons | Crystal structure | C-type cytochromes | Iron respiration | Multiheme | MtrC | SHEWANELLA | c-type cytochromes | MULTIDISCIPLINARY SCIENCES | iron respiration | PREDICTION | OUTER-MEMBRANE CYTOCHROMES | TRANSPORT | multiheme | IRON REDUCTION | OMCA | NITRITE REDUCTASE | NANOWIRES | Electron Transport | Cytochromes - chemistry | Heme - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Shewanella - metabolism | Cytochrome c Group - chemistry | Cytochromes - genetics | Cysteine - genetics | Flavin Mononucleotide - pharmacology | Heme - chemistry | Disulfides - chemistry | Cytochromes - metabolism | Oxidation-Reduction - drug effects | Cysteine - metabolism | Iron - pharmacology | Bacterial Outer Membrane Proteins - genetics | Cytochrome c Group - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Electron Spin Resonance Spectroscopy | Shewanella - genetics | Iron - chemistry | Bacterial Outer Membrane Proteins - chemistry | Models, Molecular | Binding Sites - genetics | Cysteine - chemistry | Flavin Mononucleotide - chemistry | Potentiometry | Iron - metabolism | Cytochrome c Group - metabolism | Bacterial Outer Membrane Proteins - metabolism | Protein Binding | Flavin Mononucleotide - metabolism | Biological Sciences
Journal Article
1995, 1, CRC revivals, ISBN 9780849345760, 220
This book describes cellular level sensors that act as switches, turning on gene expression and other metabolic processes necessary for cell survival and... 
Cell metabolism | Cellular signal transduction | Cytochrome b | Cell Biology
Book
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
FEBS Letters, ISSN 0014-5793, 02/2015, Volume 589, Issue 4, pp. 476 - 483
•Plant cytochrome c1, at its two binding sites, recognizes human cytochrome c.•Docking of human cytochrome c at plant cytochrome c1 is electrostatically... 
Cytochrome c | Cytochrome c oxidase | Isothermal Titration Calorimetry | Nuclear Magnetic Resonance | Supercomplex | Cytochrome bc1 | human cytochrome c | inner mitochondrial membrane | cytochrome c oxidase | DLS | Luria-Bertani | Cbc 1 | CcO | Cc 1 | CcOred | intermembrane mitochondrial space | electron transfer | plant cytochrome c 1 | reduced human cytochrome c | reduced cytochrome c oxidase | mitochondrial matrix | cytochrome c | equilibrium dissociation constant | Principal Component Analysis | plant cytochrome c | CSP | dynamic light scattering | complex IV | reduced plant cytochrome c 1 | III | IMM | hCc | human cytochrome c 1 | complex III | Heteronuclear Single-Quantum Correlation | IV | K D | IMS | cytochrome bc 1 | PCA | pCc | NMR | pCc1 | cytochrome c 1 | hCc1 | ITC | hCc red | HSQC | Chemical-Shift Perturbations | pCc 1red | Cytochrome bc | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MITOCHONDRIAL ELECTRON-TRANSPORT | SP PCC-7119 FLAVODOXIN | SYNECHOCYSTIS SP PCC-6803 | TRANSIENT COMPLEX | CELL BIOLOGY | PROGRAMMED CELL-DEATH | HYDROPHOBIC INTERACTIONS | BIOPHYSICS | PARAMAGNETIC NMR | PHOTOSYSTEM-I | CORRECT EXPRESSION | Cytochromes c - chemistry | Electron Transport Complex III - chemistry | Animals | Osmolar Concentration | Solutions | Cattle | Humans | Protein Structure, Quaternary | Models, Molecular | Nuclear Magnetic Resonance, Biomolecular | Protein Binding | Electron Transport Complex IV - chemistry | Cytochrome oxidase
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e87058
Product regioselectivity as influenced by molecular recognition is a key aspect of enzyme catalysis. We applied large-scale two-dimensional (2D) umbrella... 
OXIDATION | IN-VITRO | ACTIVATION | ACCURATE DOCKING | MULTIDISCIPLINARY SCIENCES | TOXIC METABOLITE | HYDROXYLATION | DYNAMICS | LIVER-MICROSOMES | CYP2E1 | DRUG-DRUG INTERACTIONS | Acetaminophen - metabolism | Stereoisomerism | Cytochrome P-450 CYP2C9 - chemistry | Humans | Molecular Conformation | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Cytochrome P-450 CYP2E1 - metabolism | Thermodynamics | Cytochrome P-450 CYP3A - chemistry | Molecular Structure | Cytochrome P-450 CYP2C9 - metabolism | Cytochrome P-450 CYP2E1 - chemistry | Protein Structure, Tertiary | Catalytic Domain | Cytochrome P-450 CYP1A2 - chemistry | Acetaminophen - chemistry | Cytochrome P-450 CYP2A6 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Molecular Dynamics Simulation | Cytochrome P-450 Enzyme System - chemistry | Cytochrome P-450 CYP3A - metabolism | Protein Binding | Molecular Docking Simulation | Cytochrome P-450 CYP2A6 - chemistry | Case studies | Biological products | Metabolites | Acetaminophen | Cytochrome P-450 | Molecular dynamics | Catalysis | Comparative analysis | Cytochrome | Biotechnology | Laboratories | Molecular docking | Toxicology | Analgesics | Mathematical analysis | Binding | Enzymes | Regioselectivity | Cytochrome P450 | Chemical reactions | Pharmacology | CYP1A2 protein | Metabolism | Quantum physics | Free energy | Substrates | Studies | Ligands | Conformation
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2018, Volume 13, pp. 8561 - 8575
Introduction and objective: Currently, carbon nanostructures are vastly explored materials with potential for future employment in biomedicine. The possibility... 
Nanoparticles | Carbon nanostructures | Cytochrome p450 | Liver | Microsomes | liver | POLYCYCLIC AROMATIC-HYDROCARBONS | NANOMATERIALS | NANOSCIENCE & NANOTECHNOLOGY | TOXICITY | carbon nanostructures | cytochrome P450 | INDUCTION | DRUG-METABOLIZING-ENZYMES | WALLED CARBON NANOTUBES | nanoparticles | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOCHROME-P450 ENZYME | microsomes | Cytochrome P-450 CYP2D6 - genetics | Nanostructures - ultrastructure | Cytochrome P-450 Enzyme Inhibitors | Cell Survival | Humans | Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Fluorescence | Hydrodynamics | Hepatocytes - metabolism | Diamond - chemistry | Cytochrome P-450 CYP1A2 - metabolism | Down-Regulation - genetics | Hep G2 Cells | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Nanostructures - chemistry | Graphite - chemistry | Cytochrome P-450 Enzyme System - pharmacology | Hepatocytes - drug effects | Diamond crystals | RNA | Isoenzymes | Graphene | Genes | Cytochrome P-450 | Diamonds | Graphite | Genetic research | Genetic aspects | Gene expression | Cytochrome | Enzymes | Drug delivery systems | Nanomaterials | Metabolism | Carbon | Drug dosages
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93261
Intratumoral expression of genes encoding Cytochrome P450 enzymes (CYP) might play a critical role not only in cancer development but also in the metabolism of... 
CYP3A4/5 | CYP2W1 | METABOLISM | CANCER | MULTIDISCIPLINARY SCIENCES | CHILDREN | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Prospective Studies | Follow-Up Studies | Humans | Rhabdomyosarcoma - metabolism | Gene Expression Regulation, Neoplastic | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Infant | Male | Muscle, Skeletal - metabolism | Cytochrome P-450 CYP2E1 - genetics | Gene Expression Profiling | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P450 Family 2 | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Biomarkers, Tumor - metabolism | Female | Child | Real-Time Polymerase Chain Reaction | RNA, Messenger - genetics | Cytochrome P-450 CYP1A1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | Gene Expression Regulation, Enzymologic | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 Enzyme System - genetics | Biomarkers, Tumor - genetics | Rhabdomyosarcoma - genetics | Cytochrome | Drugs | Rhabdomyosarcoma | Chemoresistance | Families & family life | Drug development | Tissues | Cancer therapies | Antitumor agents | Rodents | Drug metabolism | Children | Enzymes | Prodrugs | Cytochrome P450 | CYP gene | CYP1A2 protein | Metabolism | Gene expression | Chemical compounds | Patients | Polymerase chain reaction | Musculoskeletal system | Chemotherapy | Tumors | Cancer
Journal Article
Archives of toxicology, ISSN 1432-0738, 2014, Volume 90, Issue 2, pp. 291 - 304
The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role... 
Benzo[ a ]pyrene | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Carcinogen metabolism | DNA adducts | Pharmacology/Toxicology | Tumour suppressor p53 | Biomedicine general | Benzo[a]pyrene | DNA-ADDUCTS | METABOLIC-ACTIVATION | HUMAN CANCER-CELLS | P53 | RESPONSES | ARISTOLOCHIC ACID I | MESSENGER-RNA | MICE | TOXICOLOGY | EXPRESSION | BENZO(A)PYRENE | DNA Damage - drug effects | Cell Survival - drug effects | Cytochrome P-450 CYP1B1 - genetics | Inactivation, Metabolic | Polycyclic Aromatic Hydrocarbons - pharmacokinetics | Benzo(a)pyrene - toxicity | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Tumor Suppressor Protein p53 - metabolism | Cytochrome P-450 CYP1B1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Cytochrome P-450 CYP1A1 - metabolism | HCT116 Cells - drug effects | Tumor Suppressor Protein p53 - genetics | Carcinogens - toxicity | DNA Adducts | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cytochrome P-450 Enzyme Inducers - poisoning | DNA Damage - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 Enzyme Inducers - pharmacology | Toxicity Tests | Cytochrome P-450 Enzyme Inducers - toxicity | Metabolites | Benzopyrene | Analysis | Cytochrome P-450 | Physiological aspects | Tumor proteins | Xenobiotics | Cells | Cytochrome | Carcinogens | Polycyclic aromatic hydrocarbons | Tumors | Index Medicus | Toxicokinetics and Metabolism | Cell Survival | HCT116 Cells | Polycyclic Aromatic Hydrocarbons | Benzo(a)pyrene | NAD(P)H Dehydrogenase (Quinone) | Journal Article | Cytochrome P-450 Enzyme Inducers | Tumor Suppressor Protein p53 | Research Support, Non-U.S. Gov't | Cytochrome P-450 CYP1B1 | Cytochrome P-450 CYP1A1 | DNA Damage | Receptors, Aryl Hydrocarbon | Basic Helix-Loop-Helix Transcription Factors
Journal Article