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Nature Cell Biology, ISSN 1465-7392, 10/2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 38, pp. E7997 - E8006
Journal Article
Diabetes, ISSN 0012-1797, 06/2011, Volume 60, Issue 6, pp. 1705 - 1715
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27487 - 27498
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study. When S100B... 
WILD-TYPE P53 | UV-RADIATION | CANCER-CELLS | P53-MEDIATED APOPTOSIS | P53-INDUCED APOPTOSIS | CARCINOMA-CELLS | MDM2 GENE | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | PIFITHRIN-ALPHA | RNA, Small Interfering - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Membrane Potential, Mitochondrial - radiation effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Multiprotein Complexes - genetics | Nerve Growth Factors - metabolism | fas Receptor - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Multiprotein Complexes - metabolism | RNA, Messenger - biosynthesis | Phosphorylation - genetics | S100 Proteins - genetics | Ultraviolet Rays | Caspase 3 - genetics | fas Receptor - genetics | Biomarkers, Tumor - metabolism | Membrane Potential, Mitochondrial - genetics | Inhibitor of Apoptosis Proteins - metabolism | S100 Calcium Binding Protein beta Subunit | Down-Regulation | S100 Proteins - metabolism | Melanoma - pathology | Enzyme Activation - radiation effects | Phosphorylation - radiation effects | RNA, Neoplasm - biosynthesis | Nerve Growth Factors - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mutation | Transcription, Genetic - genetics | Enzyme Activation - genetics | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Transcription, Genetic - radiation effects | Cytochromes c - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Melanoma - genetics | Melanoma - metabolism | Cytochromes c - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cell Survival - radiation effects | Carrier Proteins - genetics | Carrier Proteins - metabolism | Apoptosis | Index Medicus | Molecular Bases of Disease | S100 Proteins | Calcium-binding Proteins | S100B | Cell Biology | p53 | Protein-Protein Interactions | Tumor Suppressor
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2008, Volume 382, Issue 3, pp. 790 - 801
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e105070 - e105070
Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid... 
ACUTE KIDNEY INJURY | OXIDATIVE STRESS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | PATHOLOGICAL ROLE | MECHANISMS | MICE | RENAL INJURY | CELL-DEATH | PROTECTS | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Caspase 9 - genetics | Caspase 9 - metabolism | Kidney - pathology | Blood Urea Nitrogen | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Male | Cytochromes c - genetics | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Antineoplastic Agents - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Kidney - metabolism | Cisplatin - toxicity | Caspase 3 - genetics | Flavonoids - pharmacology | Cisplatin - antagonists & inhibitors | NF-KappaB Inhibitor alpha | Kidney - drug effects | Signal Transduction | Cytochromes c - metabolism | Gene Expression Regulation | Rats | Antioxidants - pharmacology | Flavonoids - pharmacokinetics | Rats, Sprague-Dawley | Animals | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Creatinine - blood | Peroxidase - genetics | Antioxidants - pharmacokinetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Cytochrome | Bcl-2 protein | Syngeneic grafts | C protein | Cytotoxicity | Cytosol | Caspase-3 | NAD(P)H oxidase | Antioxidants | Proteins | Elevation | Mitochondria | Enzymatic activity | Animal tissues | Bioindicators | Medical research | NF-κB protein | Committees | Gene expression | Studies | Cytochrome c | Urea | Chemistry | Chemotherapy | Flavonoids | Caspase-9 | Biomarkers | Kidney transplantation | Oxidative stress | Enzyme activity | Bax protein | Platinum | Rodents | CYBB protein | Peroxidase | Pharmaceutical sciences | Creatinine | Translocation | Antiinflammatory agents | Kidneys | Caspase | Inflammation | Pharmacology | Cisplatin | Acids | Apoptosis | Cancer | Index Medicus
Journal Article
JAMA, ISSN 0098-7484, 07/2009, Volume 302, Issue 3, pp. 261 - 275
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 21, pp. 17065 - 17076
The role and the mechanisms by which β1 integrins regulate the survival and chemoresistance of T cell acute lymphoblastic leukemia (T-ALL) still are poorly... 
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Caspase 9 - genetics | Caspase 9 - metabolism | Antibiotics, Antineoplastic - pharmacology | Humans | Caspase 3 - metabolism | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Cytochromes c - genetics | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Collagen Type I - genetics | MAP Kinase Signaling System - genetics | Caspase 3 - genetics | Female | JNK Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Collagen Type I - metabolism | Jurkat Cells | Cytochromes c - metabolism | Fibronectins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Myeloid Cell Leukemia Sequence 1 Protein | Fibronectins - genetics | Integrin alpha2beta1 - metabolism | Integrin alpha2beta1 - genetics | Enzyme Activation - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Index Medicus | Signal Transduction | JNK | T Cell Leukemia | Alpha2beta1 Integrin | Cell Signaling | Collagen 1 | MAPK | Anticancer Drug | Apoptosis | Bcl-2 Family Proteins | Integrins | ERK
Journal Article
by Newton-Cheh, Christopher and Johnson, Toby and Gateva, Vesela and Tobin, Martin D and Bochud, Murielle and Coin, Lachlan and Najjar, Samer S and Zhao, Jing Hua and Heath, Simon C and Eyheramendy, Susana and Papadakis, Konstantinos and Voight, Benjamin F and Scott, Laura J and Zhang, Feng and Farrall, Martin and Tanaka, Toshiko and Wallace, Chris and Chambers, John C and Khaw, Kay-Tee and Nilsson, Peter and van der Harst, Pim and Polidoro, Silvia and Grobbee, Diederick E and Onland-Moret, N. Charlotte and Bots, Michiel L and Wain, Louise V and Elliott, Katherine S and Teumer, Alexander and Luan, Jian'an and Lucas, Gavin and Kuusisto, Johanna and Burton, Paul R and Hadley, David and McArdle, Wendy L and Brown, Morris and Dominiczak, Anna and Newhouse, Stephen J and Samani, Nilesh J and Webster, John and Zeggini, Eleftheria and Beckmann, Jacques S and Bergmann, Sven and Lim, Noha and Song, Kijoung and Vollenweider, Peter and Waeber, Gerard and Waterworth, Dawn M and Yuan, Xin and Groop, Leif and Orho-Melander, Marju and Allione, Alessana and Di Gregorio, Alessana and Guarrera, Simonetta and Panico, Salvatore and Ricceri, Fulvio and Romanazzi, Valeria and Sacerdote, Carlotta and Vineis, Paolo and Barroso, Ines and Sandhu, Manjinder S and Luben, Robert N and Crawford, Gabriel J and Jousilahti, Pekka and Perola, Markus and Boehnke, Michael and Bonnycastle, Lori L and Collins, Francis S and Jackson, Anne U and Mohlke, Karen L and Stringham, Heather M and Valle, Timo T and Willer, Cristen J and Bergman, Richard N and Morken, Mario A and Doering, Angela and Gieger, Christian and Illig, Thomas and Meitinger, Thomas and Org, Elin and Pfeufer, Arne and Wichmann, H. Erich and Kathiresan, Sekar and Marrugat, Jaume and O'Donnell, Christopher J and Schwartz, Stephen M and Siscovick, David S and