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1. Full Text Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
by Martin J. Boulanger and Dar-Chone Chow and Elena E. Brevnova and K. Christopher Garcia
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2003, Volume 300, Issue 5628, pp. 2101 - 2104
Molecules | Receptors | Cytokines | Surface areas | Reports | Titration | Epitopes | Signal reflection | Electron density | Symmetry | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Structure in molecular biology | Molecular biophysics | Crystalline structure | Protein Structure, Tertiary | Receptors, Interleukin-6 - chemistry | Cytokine Receptor gp130 | Membrane Glycoproteins - metabolism | Protein Structure, Secondary | Signal Transduction | Humans | Interleukin-6 - chemistry | Membrane Glycoproteins - chemistry | Models, Molecular | Crystallography, X-Ray | Antigens, CD - metabolism | Macromolecular Substances | Thermodynamics | Protein Binding | Protein Conformation | Antigens, CD - chemistry | Binding Sites | Interleukin-6 - metabolism | Receptors, Interleukin-6 - metabolism | Cellular biology | Immunology | Index Medicus
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2. Full Text Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection
by Harker, James A and Dolgoter, Aleksandr and Zuniga, Elina I
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2013, Volume 39, Issue 3, pp. 548 - 559
Life Sciences & Biomedicine | Immunology | Science & Technology | Lymphocytic choriomeningitis virus - immunology | CD8-Positive T-Lymphocytes - cytology | Lymphocytic Choriomeningitis - virology | Cytokine Receptor gp130 - metabolism | Cell Survival | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Lymphocytic Choriomeningitis - immunology | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Animals | Mice | Interleukins - biosynthesis | Receptors, Cytokine - metabolism | Receptors, Interleukin-6 | CD8-Positive T-Lymphocytes - immunology | Receptors, Cytokine - genetics | Interleukin-27 - metabolism | Medical research | Hepatitis | T cell receptors | Rodents | Viral infections | Index Medicus
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3. Full Text A gp130-Src-YAP module links inflammation to epithelial regeneration
by Taniguchi, Koji and Wu, Li-Wha and Grivennikov, Sergei I and De Jong, Petrus R and Lian, Ian and Yu, Fa-Xing and Wang, Kepeng and Ho, Samuel B and Boland, Brigid S and Chang, John T and Sandborn, William J and Hardiman, Gary and Raz, Eyal and Maehara, Yoshihiko and Yoshimura, Akihiko and Zucman-Rossi, Jessica and Guan, Kun-Liang and Karin, Michael
Nature (London), ISSN 0028-0836, 03/2015, Volume 519, Issue 7541, pp. 57 - 62
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Up-Regulation | Intestinal Mucosa - metabolism | Body Weight | Cell Proliferation | Epithelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Homeostasis | Phosphoproteins - metabolism | Inflammatory Bowel Diseases - metabolism | Intestinal Mucosa - cytology | Inflammation - metabolism | Inflammatory Bowel Diseases - pathology | HEK293 Cells | Cell Differentiation | Epithelial Cells - cytology | Disease Models, Animal | Proto-Oncogene Proteins c-yes - metabolism | Cytokine Receptor gp130 - metabolism | Signal Transduction | Epithelial Cells - pathology | Regeneration | Animals | Proto-Oncogene Proteins pp60(c-src) - metabolism | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle Proteins | Intestinal Mucosa - pathology | Cytokines | Epithelial cells | Analysis | Gastrointestinal diseases | Colorectal cancer | Research | Phosphotransferases | Signal transduction | Cell growth | Phosphorylation | Rodents | Stem cells | Ligands | Kinases | Tissues | Small intestine | Cancer | Index Medicus
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4. Full Text STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
by Ernst, Matthias and Najdovska, Meri and Grail, Dianne and Lundgren-May, Therese and Buchert, Michael and Tye, Hazel and Matthews, Vance B and Armes, Jane and Bhathal, Prithi S and Hughes, Norman R and Marcusson, Eric G and Karras, James G and Na, Songqing and Sedgwick, Jonathon D and Hertzog, Paul J and Jenkins, Brendan J
The Journal of clinical investigation, ISSN 0021-9738, 05/2008, Volume 118, Issue 5, pp. 1727 - 1738
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cytokine Receptor gp130 - genetics | Humans | Oligonucleotides, Antisense - metabolism | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Stomach - metabolism | Protein Subunits - metabolism | Inflammation - metabolism | Stomach - anatomy & histology | STAT3 Transcription Factor - genetics | Protein Subunits - genetics | Stomach - pathology | Cytokine Receptor gp130 - immunology | Interleukin-11 - genetics | Mice, Transgenic | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Mice, Knockout | Animals | Oligonucleotides, Antisense - genetics | Interleukin-6 - immunology | Signal Transduction - physiology | Interleukin-11 - immunology | Mice | STAT3 Transcription Factor - immunology | Polymerase chain reaction | Usage | Care and treatment | Prognosis | Helicobacter pylori | Genetic aspects | Research | Diagnosis | Health aspects | Stomach cancer | Risk factors | Index Medicus | Abridged Index Medicus
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5. Full Text Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling
by Ahmad, R and Kumar, B and Chen, Z and Chen, X and Müller, D and Lele, S.M and Washington, M.K and Batra, S.K and Dhawan, P and Singh, A.B
Oncogene, ISSN 0950-9232, 11/2017, Volume 36, Issue 47, pp. 6592 - 6604
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | Intestinal Mucosa - metabolism | Adenocarcinoma - pathology | Colorectal Neoplasms - genetics | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Carcinogenesis - metabolism | Colonic Neoplasms - metabolism | Claudin-3 - genetics | Epithelial-Mesenchymal Transition | Claudin-3 - metabolism | Adenocarcinoma - genetics | STAT3 Transcription Factor - metabolism | Wnt Signaling Pathway | Colorectal Neoplasms - mortality | Cytokine Receptor gp130 - metabolism | Permeability | beta Catenin - metabolism | Colon - metabolism | Mice, Knockout | Animals | Cell Transformation, Neoplastic | Mice | Colorectal Neoplasms - pathology | Adenocarcinoma - mortality | Index Medicus | Barrier Dysfunction | Colon cancer | Proliferation | Dedifferentiation | Invasion | Tight Junction
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6. Full Text Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
by Rebouissou, Sandra and Amessou, Mohamed and Couchy, Gabrielle and Poussin, Karine and Imbeaud, Sandrine and Pilati, Camilla and Izard, Tina and Balabaud, Charles and Bioulac-Sage, Paulette and Zucman-Rossi, Jessica
Nature, ISSN 0028-0836, 01/2009, Volume 457, Issue 7226, pp. 200 - 204
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Tumors | Inflammation - pathology | Cytokine Receptor gp130 - metabolism | Signal Transduction | Cytokine Receptor gp130 - genetics | Humans | Adenoma, Liver Cell - pathology | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Cell Line, Tumor | Inflammation - genetics | Interferons - metabolism | Interleukin-6 - metabolism | Adenoma, Liver Cell - genetics | STAT3 Transcription Factor - metabolism | Sequence Deletion - genetics | Immune response | Chromosome deletion | Cellular signal transduction | Regulation | Research | Interleukin-6 | Proteins | Studies | Rodents | Kinases | Cells | Binding sites | Crystal structure | Index Medicus | Sequence Deletion | Hépatology and Gastroenterology | Cytokine Receptor gp130 | Interferons | Inflammation | oncogene | Life Sciences | mutation | Human health and pathology | hepatocellular adenoma | Adenoma, Liver Cell | STAT3 Transcription Factor | gp130 | heaptocellular carcinoma | pathology | genetics | metabolism
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7. Full Text Analysis of IL‐6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M
by Hsu, Meng‐Ping and Frausto, Ricardo and Rose‐John, Stefan and Campbell, Iain L
Glia, ISSN 0894-1491, 01/2015, Volume 63, Issue 1, pp. 132 - 141
signal transducers and activators of transcription | gp130 | receptor | signal transduction | Signal transduction | Gp130 | Receptor | Signal transducers and activators of transcription | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | Animals | Receptors, Oncostatin M - metabolism | Mice, Inbred C57BL | Oncostatin M - metabolism | Signal Transduction - physiology | Trans-Activators - metabolism | Receptors, Antigen, B-Cell - metabolism | Interleukin-6 - metabolism | Antigens, CD - metabolism | Astrocytes - metabolism | Receptors, Interleukin-6 - metabolism | RNA | Interleukins | Cytokines | Kinases | Medical research | Index Medicus
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8. Full Text Bazedoxifene as a novel GP130 inhibitor for pancreatic cancer therapy
by Wu, Xiaojuan and Cao, Yang and Xiao, Hui and Li, Chenglong and Lin, Jiayuh
Molecular cancer therapeutics, ISSN 1535-7163, 11/2016, Volume 15, Issue 11, pp. 2609 - 2619
Life Sciences & Biomedicine | Oncology | Science & Technology | Phosphorylation | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Molecular Conformation | STAT Transcription Factors - metabolism | Bone Density Conservation Agents | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Disease Models, Animal | Cell Survival - drug effects | Cytokine Receptor gp130 - metabolism | Cytokines - metabolism | Cytokine Receptor gp130 - chemistry | Pancreatic Neoplasms - pathology | Models, Molecular | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Animals | Cytokine Receptor gp130 - antagonists & inhibitors | Selective Estrogen Receptor Modulators | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | Mice | Indoles - chemistry | Index Medicus | Bazedoxifene | STAT3 | GP130 | STAT3 phosphylation | Pancreatic Cancer | Drug resistance | IL-6
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9. Full Text Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling
by Zhu, Hong-Jian and Inglese, Melissa and Waring, Paul and Jones, Simon A and Giraud, Andrew S and Grail, Dianne and Najdovska, Meri and Jenkins, Brendan J and Baumann, Heinz and Nheu, Thao and Judd, Louise M and Topley, Nicholas and Boussioutas, Alex and Wang, Bo and Ernst, Matthias and McLoughlin, Rachel M
Nature medicine, ISSN 1078-8956, 08/2005, Volume 11, Issue 8, pp. 845 - 852
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Cytokine Receptor gp130 - metabolism | Cytokine Receptor gp130 - genetics | Stomach Neoplasms - metabolism | Immunoblotting | Reverse Transcriptase Polymerase Chain Reaction | Stomach Neoplasms - physiopathology | Adenoma - metabolism | Adenoma - physiopathology | Animals | Histological Techniques | Mice, Mutant Strains | Signal Transduction - physiology | Mice | Transcriptional Activation - physiology | Transforming Growth Factor beta - metabolism | STAT3 Transcription Factor - metabolism | Smad7 Protein - metabolism | Index Medicus
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