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Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Immunity, ISSN 1074-7613, 04/2014, Volume 40, Issue 4, pp. 477 - 489
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including... 
PATHWAYS | TARGET GENES | FOXP3 OCCUPANCY | T(H)17 | REGULATORY NETWORK | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | PSORIASIS | ANTI-INTERLEUKIN-17 MONOCLONAL-ANTIBODY | TH17 CELLS | Myelin-Oligodendrocyte Glycoprotein - immunology | T-Lymphocyte Subsets - immunology | Transcription, Genetic - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Encephalomyelitis, Autoimmune, Experimental - immunology | Structure-Activity Relationship | Gene Regulatory Networks - drug effects | Cell Lineage - drug effects | Systems Biology | Benzhydryl Compounds - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Th17 Cells - drug effects | T-Lymphocyte Subsets - drug effects | Peptide Fragments - immunology | Protein Binding - drug effects | Benzeneacetamides - chemistry | Benzeneacetamides - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Heterocyclic Compounds, 4 or More Rings - chemistry | Digoxin - chemistry | Digoxin - pharmacology | Mice, Knockout | Animals | Androstenols - chemistry | Cell Differentiation - drug effects | Cell Line, Tumor | Multiple Sclerosis - immunology | Th17 Cells - immunology | Benzhydryl Compounds - pharmacology | Mice | Multiple Sclerosis - drug therapy
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 7, pp. 620 - 628
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 04/2017, Volume 13, Issue 4, pp. 217 - 233
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and... 
LIGAND 1A TL1A | COLLAGEN-INDUCED ARTHRITIS | FIBROBLAST-LIKE SYNOVIOCYTES | TUMOR-NECROSIS-FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | LYMPHOTOXIN-BETA-RECEPTOR | SYNOVIAL FIBROBLASTS | CD4(+) T-CELLS | CD40 LIGAND | MONOCLONAL-ANTIBODY | RHEUMATOLOGY | Fas Ligand Protein - metabolism | Rheumatic Diseases - drug therapy | OX40 Ligand - metabolism | CD27 Ligand - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Lymphotoxin-alpha - metabolism | Molecular Targeted Therapy | 4-1BB Ligand - antagonists & inhibitors | TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors | CD40 Ligand - metabolism | CD27 Ligand - metabolism | Cell Death | Rheumatic Diseases - immunology | Signal Transduction | Lymphocyte Activation | Tumor Necrosis Factors - metabolism | 4-1BB Ligand - metabolism | Immune Tolerance | Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Tumor Necrosis Factors - immunology | OX40 Ligand - antagonists & inhibitors | Cytokine TWEAK | Fas Ligand Protein - antagonists & inhibitors | Animals | Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors | T-Lymphocytes - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - antagonists & inhibitors | CD40 Ligand - antagonists & inhibitors | Lymphotoxin-alpha - antagonists & inhibitors | Tumor Necrosis Factors - antagonists & inhibitors | Care and treatment | Cytokines | Tumor necrosis factor | Rheumatic diseases | Development and progression | Genetic aspects | Health aspects
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 498 - 502
There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous... 
UNITED-STATES | 1918 SPANISH INFLUENZA | ACTIVATION | VIRUS | ENDOTOXIN ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INHIBITORS | TETRASODIUM E5564 | SEVERE SEPSIS | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Lipopolysaccharide Receptors - metabolism | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Time Factors | Acute Lung Injury - prevention & control | Female | Acute Lung Injury - drug therapy | Disaccharides - therapeutic use | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - genetics | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Antiviral Agents - pharmacology | Sugar Phosphates - therapeutic use | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Acute Lung Injury - pathology | Animals | Sugar Phosphates - metabolism | Survival Analysis | Toll-Like Receptor 2 - immunology | Ligands | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Acute Lung Injury - complications | Prevention | Toll-like receptors | Health aspects | Influenza | Pathology | Cell culture | Respiratory distress syndrome | Cytokines | Mortality | Rodents | Sepsis | Infections | Gene expression | Drug dosages
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5997, pp. 1345 - 1348
Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells... 
Hep G2 cells | Cytokines | REPORTS | Stem cells | Multipotent stem cells | Bone marrow | Cultured cells | Transplantation | Aryl hydrocarbon receptors | Hematopoietic stem cells | Blood | EX-VIVO EXPANSION | ENGRAFTMENT | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | BIOLOGY | MICE | UMBILICAL-CORD BLOOD | BINDING | TRANSPLANTATION | Antigens, CD34 - analysis | Cell Proliferation | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Species Specificity | Cell Count | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Antigens, CD - analysis | Multipotent Stem Cells - drug effects | Hematopoiesis | Polychlorinated Dibenzodioxins - pharmacology | Hematopoietic Stem Cells - physiology | Receptors, Aryl Hydrocarbon - metabolism | Multipotent Stem Cells - physiology | Hematopoietic Stem Cells - drug effects | Signal Transduction | Purines - metabolism | Purines - pharmacology | Cells, Cultured | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Mice, SCID | AC133 Antigen | Aryl Hydrocarbon Hydroxylases - metabolism | Cell Lineage | Animals | Multipotent Stem Cells - cytology | Small Molecule Libraries | Hematopoietic Stem Cells - cytology | Cytochrome P-450 CYP1B1 | Mice, Inbred NOD | Mice | Glycoproteins - analysis | Cytokines - pharmacology | Peptides - analysis | Physiological aspects | Arylation
Journal Article