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Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2350 - 2360
Journal Article
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 443 - 456
The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse... 
NATURAL-KILLER-CELLS | ACTIVATION | CMV REACTIVATION | INNATE | RECEPTOR | FCR-GAMMA | DIFFERENTIATION | IMMUNOLOGY | PLZF CONTROLS | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Transcription Factors - deficiency | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | T-Lymphocytes, Cytotoxic - pathology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Kruppel-Like Transcription Factors - deficiency | Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | T-Lymphocytes, Cytotoxic - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Transcription Factors - genetics | Killer Cells, Natural - classification | Promyelocytic Leukemia Zinc Finger Protein | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | GPI-Linked Proteins - genetics | Virus diseases | Proteins | Epigenetic inheritance | Killer cells | Immunotherapy | Genomics | Medical genetics | Cytomegalovirus infections | T cells | Methylation | Health aspects | Antigens | Flow cytometry | Cytomegalovirus | Data analysis | Biomedical research | Transplants & implants | Cytokines | Leukemia | Cytotoxicity | Infections | Kinases | Diversification | Gene expression | Experiments | Scholarships & fellowships | Lymphocytes | DNA methylation | Epigenetics | Viral infections | Immune system | Cancer | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 01/2016, Volume 65, Issue 1, pp. 285 - 296
The rapid rise in the incidence of type 1 diabetes (T1D) suggests the involvement of environmental factors including viral infections. We evaluated the... 
UNITED-STATES | BETA-CELLS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | ISLET AUTOIMMUNITY | POLYMERASE CHAIN-REACTION | COXSACKIE-B | CYTOMEGALOVIRUS-INFECTION | BARR-VIRUS INFECTION | ENTEROVIRUS INFECTIONS | IGM RESPONSES | Zinc Transporter 8 | Humans | Mumps virus - immunology | Rotavirus - immunology | Viral Proteins - immunology | Child, Preschool | Male | Cytomegalovirus Infections - immunology | Case-Control Studies | Young Adult | Adult | Female | Rubella virus - immunology | Diabetes Mellitus, Type 1 - immunology | Epstein-Barr Virus Infections | Glutamate Decarboxylase - immunology | Child | Mumps - immunology | Rubella - immunology | Diabetes Mellitus, Type 1 - virology | Herpesvirus 4, Human - immunology | Rotavirus Infections - immunology | Cytomegalovirus - immunology | Autoantibodies - immunology | High-Throughput Screening Assays | Adolescent | Proteomics | Enterovirus B, Human - immunology | Protein Array Analysis | Antibodies, Viral - immunology | Endogenous Retroviruses - immunology | Cation Transport Proteins - immunology | Coxsackievirus Infections - immunology | Viral antibodies | Virus diseases | Antiviral agents | Care and treatment | Type 1 diabetes | Antibodies | Dosage and administration | Viruses | Immunoglobulins | Diabetes | Viral infections | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes
Journal Article
Blood, ISSN 0006-4971, 03/2005, Volume 105, Issue 6, pp. 2473 - 2479
The tyrosine kinase inhibitor imatinib (imatinib, ST1571, Glivec, and Gleevec) is increasingly used in patients undergoing allogeneic transplantation for... 
CHRONIC MYELOGENOUS LEUKEMIA | RHEUMATOID-ARTHRITIS | LYMPHOCYTE RESPONSES | DENDRITIC CELLS | VIRUS INFECTION | TYROSINE KINASE | HEALTHY-INDIVIDUALS | STEM-CELL | HEMATOLOGY | ANTIGEN RECEPTOR | CHRONIC MYELOID-LEUKEMIA | Immunodominant Epitopes - immunology | CD8-Positive T-Lymphocytes - cytology | Humans | Graft vs Host Disease - immunology | Stem Cell Transplantation | Lymphocyte Activation - immunology | Protein Kinase Inhibitors - immunology | Adaptor Proteins, Signal Transducing - immunology | Receptors, Antigen, T-Cell - immunology | Phosphorylation - drug effects | Protein Processing, Post-Translational - immunology | Jurkat Cells | Lectins, C-Type | Leukemia - therapy | Piperazines - therapeutic use | Pyrimidines - pharmacology | Piperazines - pharmacology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors | Signal Transduction - drug effects | Up-Regulation - immunology | Leukemia - immunology | ZAP-70 Protein-Tyrosine Kinase - immunology | Graft vs Leukemia Effect - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Pyrimidines - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Transplantation, Homologous | Dose-Response Relationship, Drug | Signal Transduction - immunology | Interleukin-2 - immunology | Protein Processing, Post-Translational - drug effects | Antigens, Differentiation, T-Lymphocyte - immunology | Herpesvirus 4, Human - immunology | Membrane Proteins - immunology | Clinical Trials as Topic | Imatinib Mesylate | Receptors, Interleukin-2 - immunology | Sequence Homology, Nucleic Acid | Up-Regulation - drug effects | Cytomegalovirus - immunology | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Piperazines - immunology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Benzamides | Genome, Human - immunology | Protein Structure, Tertiary - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 12, pp. 3301 - 3310
CD3(+)CD56(+) cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a... 
IMMUNOLOGICAL EFFECTOR-CELLS | SEVERE COMBINED IMMUNODEFICIENCY | NKG2D | DENDRITIC CELLS | IN-VIVO | ANTITUMOR-ACTIVITY | NECTIN-2 CD112 | HEMATOLOGY | PHASE-I | INDUCED KILLER-CELLS | CELIAC-DISEASE | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | Humans | Natural Cytotoxicity Triggering Receptor 3 - metabolism | NK Cell Lectin-Like Receptor Subfamily K - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - metabolism | Lymphocyte Function-Associated Antigen-1 - immunology | Signal Transduction - immunology | T-Lymphocytes, Cytotoxic - drug effects | Flow Cytometry | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Neoplasms - genetics | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Natural Cytotoxicity Triggering Receptor 3 - immunology | CD56 Antigen - immunology | Cytotoxicity, Immunologic - drug effects | Antibodies, Monoclonal - immunology | T-Lymphocytes, Cytotoxic - immunology | Cytokine-Induced Killer Cells - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antibodies, Monoclonal - pharmacology | Antigens, Differentiation, T-Lymphocyte - metabolism | Cytokine-Induced Killer Cells - immunology | Cytomegalovirus - growth & development | Cytomegalovirus - immunology | Killer Cells, Natural - cytology | Signal Transduction - drug effects | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | CD3 Complex - immunology | Cell Line, Tumor | Cytokine-Induced Killer Cells - cytology | Killer Cells, Natural - metabolism | Primary Cell Culture | Neoplasms - pathology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4415 - 4420
Primary immunodeficiencies are often monogenic disorders characterized by vulnerability to specific infectious pathogens. Here, we performed whole-exome... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | ACTIVATOR | INTERFERON-GAMMA | MYCOBACTERIAL DISEASE | ALPHA/BETA | MENDELIAN SUSCEPTIBILITY | CLINICAL-FEATURES | DEFICIENCY | SIGNAL TRANSDUCER | INBORN-ERRORS | Bacteremia - immunology | Genetic Diseases, Inborn - microbiology | STAT2 Transcription Factor - immunology | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - virology | Male | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Bacteremia - microbiology | Streptococcal Infections - genetics | Phosphorylation - genetics | Female | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Fibroblasts - microbiology | Mycobacterium Infections, Nontuberculous - immunology | Immunologic Deficiency Syndromes - immunology | Receptors, Interferon - genetics | Fibroblasts - virology | Genetic Diseases, Inborn - immunology | Viremia - genetics | Viridans Streptococci - immunology | Bacteremia - genetics | Immunologic Deficiency Syndromes - virology | STAT1 Transcription Factor - genetics | Immunologic Deficiency Syndromes - microbiology | STAT1 Transcription Factor - immunology | Cytomegalovirus - immunology | Mycobacterium abscessus - immunology | Receptor, Interferon alpha-beta - immunology | Receptors, Interferon - immunology | Viremia - virology | STAT2 Transcription Factor - genetics | Immunologic Deficiency Syndromes - genetics | Fibroblasts - immunology | Viremia - immunology | Streptococcal Infections - immunology | Mutation | Mycobacterium Infections, Nontuberculous - genetics | Virus diseases | Usage | Immunotherapy | Genetic aspects | Disease susceptibility | Research | Mutation (Biology) | Stat2 protein | Cytomegalovirus | Phosphorylation | Viremia | Immunodeficiency | Stop codon | C-Terminus | Gene deletion | Bacteremia | Nuclear transport | α-Interferon | Clonal deletion | Fibroblasts | Interferon | Codons | Stat1 protein | Viral infections | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2007, Volume 81, Issue 18, pp. 9838 - 9850
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TOLL-LIKE RECEPTOR-3 | DOUBLE-STRANDED-RNA | INNATE IMMUNE RECOGNITION | VIROLOGY | NITRIC-OXIDE SYNTHASE | GAMMA-INTERFERON | INTERFERON REGULATORY FACTOR-3 | HUMAN FETAL ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | HUMAN-IMMUNODEFICIENCY-VIRUS | HUMAN-CYTOMEGALOVIRUS | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Encephalitis, Viral - genetics | Membrane Glycoproteins - metabolism | Virus Replication - genetics | Humans | NF-kappa B - metabolism | Cytomegalovirus Infections - immunology | Astrocytes - enzymology | Cytomegalovirus Infections - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Tryptophan - metabolism | HIV Infections - immunology | Cytomegalovirus - genetics | Virus Replication - drug effects | Poly I-C - pharmacology | Viral Envelope Proteins - genetics | Microglia - enzymology | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 3 - agonists | Toll-Like Receptor 3 - metabolism | Macrophages - enzymology | Gene Expression Regulation, Enzymologic - genetics | Tryptophan - immunology | Ligands | Encephalitis, Viral - immunology | Gene Expression Regulation, Enzymologic - drug effects | NF-kappa B - immunology | Kynurenine - genetics | HIV Infections - enzymology | Encephalitis, Viral - enzymology | Macrophages - virology | Microglia - immunology | Astrocytes - immunology | Viral Envelope Proteins - metabolism | Kynurenine - metabolism | Membrane Glycoproteins - immunology | Astrocytes - virology | Macrophages - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Nitric Oxide - immunology | HIV Infections - genetics | Cells, Cultured | Virus Replication - immunology | HIV-1 - genetics | Proteins - immunology | Membrane Glycoproteins - genetics | Cytomegalovirus - immunology | Cytomegalovirus Infections - enzymology | HIV-1 - immunology | Proteins - metabolism | Microglia - virology | Interferon Regulatory Factor-3 - metabolism | Viral Envelope Proteins - immunology | Gene Expression Regulation, Enzymologic - immunology | Nitric Oxide - metabolism | Kynurenine - immunology | Cytokines - pharmacology | Interferon Inducers - pharmacology | Index Medicus | Cellular Response to Infection
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2006, Volume 176, Issue 4, pp. 2645 - 2653
The age-associated decrease in functionality of the human immune system is thought to have a negative impact on the capacity to provide protection against... 
SWEDISH NONA IMMUNE | LYMPHOCYTE SUBPOPULATIONS | MEMORY | EXPANSIONS | OLD | SUBSETS | OCTO-IMMUNE | INFECTION | IMMUNOLOGY | IMMUNE RISK PHENOTYPE | AGE | CD8-Positive T-Lymphocytes - cytology | Clone Cells - cytology | CD8-Positive T-Lymphocytes - pathology | Humans | Male | Cytomegalovirus Infections - immunology | Interferon-gamma - metabolism | Cytomegalovirus Infections - mortality | CD4-Positive T-Lymphocytes - immunology | Cytomegalovirus - immunology | Aging - immunology | Phenotype | Clone Cells - immunology | Aged, 80 and over | Cytomegalovirus Infections - virology | Female | Receptors, Antigen, T-Cell - immunology | CD8-Positive T-Lymphocytes - immunology | Longitudinal Studies | Index Medicus | Abridged Index Medicus | INTERDISCIPLINARY RESEARCH AREAS | Social Sciences | Other Social Sciences | Cytomegalovirus/immunology | Interferon Type II/secretion | CD8-Positive T-Lymphocytes/cytology/immunology/pathology | Äldre och åldrande | Samhällsvetenskap | Clone Cells/cytology/immunology | TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN | Older people and ageing | Other Social Sciences not elsewhere specified | CD4-Positive T-Lymphocytes/immunology | Aged; 80 and over | Cytomegalovirus Infections/immunology/mortality/virology | Övrig annan samhällsvetenskap | Receptors; Antigen; T-Cell/immunology | Aging/immunology | Annan samhällsvetenskap
Journal Article
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 431 - 442
Long-lived “memory-like” NK cells have been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about how the memory-like... 
ADAPTIVE IMMUNITY | CD94/NKG2C RECEPTOR | REPERTOIRE | NATURAL-KILLER-CELLS | ACTIVATION | TYROSINE KINASE | FCR-GAMMA | UMBILICAL-CORD BLOOD | DIFFERENTIATION | IMMUNOLOGY | CHILDREN | Cell Proliferation | Humans | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Killer Cells, Natural - classification | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Immunologic Memory | GPI-Linked Proteins - genetics | Proteins | Viral antibodies | Epigenetic inheritance | Killer cells | Molecular genetics | Antibodies | Gene expression | Antigens | Cytomegalovirus | Cloning | Colleges & universities | Infections | Experiments | Long term | DNA methylation | Epigenetics | Expansion | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
Journal Article