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Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2916, 06/2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2009, Volume 86, Issue 4, pp. 863 - 875
...Abbreviations BPIL2 bactericidal/permability‐increasing protein HEK human embryonic kidney IB immunoblotting IP immunoprecipitation PAMPs pathogen‐associated... 
monocytes/macrophages | lipopolysaccharide | signal transduction | suppression/anergy | cell activation | Lipopolysaccharide | Signal transduction | Cell activation | Monocytes/macrophages | Suppression/anergy | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology | Protein Kinase C - genetics | Cytoskeletal Proteins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Suppressor of Cytokine Signaling 1 Protein | Monocytes - metabolism | Monocytes - immunology | Armadillo Domain Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Regulatory Factor-3 - genetics | Lipopolysaccharides - immunology | Signal Transduction - immunology | Protein Kinase C - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | Cytokines - metabolism | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Myeloid Differentiation Factor 88 - genetics | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Protein Kinase C - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Adaptor Proteins, Vesicular Transport - immunology | Armadillo Domain Proteins - immunology | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Armadillo Domain Proteins - metabolism | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Suppressor of Cytokine Signaling Proteins - metabolism | Myeloid Differentiation Factor 88 - metabolism | Index Medicus | monocytes | macrophages | suppression | Receptors, Signal Transduction, & Genes | anergy
Journal Article
PLoS pathogens, ISSN 1553-7374, 08/2009, Volume 5, Issue 8, pp. e1000559 - e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Index Medicus | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 10/2009, Volume 183, Issue 8, pp. 5208 - 5220
The role of proinflammatory cytokine production in the pathogenesis of malaria is well established, but the identification of the parasite products that... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-1alpha - immunology | Chemokine CCL2 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | NF-kappa B - metabolism | Inflammation - parasitology | Endothelial Cells - parasitology | Extracellular Signal-Regulated MAP Kinases - immunology | Plasmodium falciparum | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Carrier Proteins - immunology | Toll-Like Receptors - immunology | Chemokine CXCL1 - immunology | Signal Transduction - drug effects | Interleukin-6 - immunology | Malaria, Falciparum - immunology | Uric Acid - antagonists & inhibitors | Mice | Interleukin-8 - immunology | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | NF-kappa B - immunology | Interleukin-1alpha - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Hemeproteins - immunology | Macrophages - parasitology | Signal Transduction - immunology | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Chemokine CCL2 - metabolism | Macrophages - immunology | Uric Acid - metabolism | Interleukin-1beta - immunology | Hemeproteins - pharmacology | Inflammation - immunology | Endothelial Cells - immunology | Malaria, Falciparum - parasitology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Allopurinol - pharmacology | Macrophages - drug effects | Myeloid Differentiation Factor 88 - metabolism | Interferon-gamma - pharmacology | Endothelial Cells - drug effects | Index Medicus | Abridged Index Medicus | Chemokine | TLR9 | Plasmodium | Inflammasome | NALP3 | Cytokine
Journal Article
PloS one, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53531 - e53531
Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB), the synthetic... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adjuvants, Immunologic - administration & dosage | Cytoskeletal Proteins - genetics | Receptors, Interleukin-1 - genetics | Antigens, Bacterial - immunology | Interleukin-17 - immunology | Lectins, C-Type - immunology | Lectins, C-Type - genetics | Th1 Cells - immunology | Cytoskeletal Proteins - deficiency | Membrane Proteins - deficiency | Molecular Mimicry | Adjuvants, Immunologic - chemistry | Myeloid Differentiation Factor 88 - immunology | Interferon-gamma - genetics | Lectins, C-Type - deficiency | Tuberculosis Vaccines - immunology | Adaptive Immunity | Immunization | Vaccines, Subunit | Antigens, Bacterial - chemistry | Signal Transduction | Membrane Proteins - genetics | Receptors, Interleukin-1 - immunology | Cord Factors - chemistry | Tuberculosis Vaccines - administration & dosage | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | Interleukin-17 - genetics | Membrane Proteins - immunology | Cord Factors - immunology | Mice, Knockout | Tuberculosis - immunology | Animals | Apoptosis Regulatory Proteins | Cytoskeletal Proteins - immunology | Tuberculosis Vaccines - chemistry | CARD Signaling Adaptor Proteins | Interferon-gamma - immunology | Tuberculosis - prevention & control | Th17 Cells - immunology | Mice | Lectins | Antigens | Membrane lipids | Tuberculosis vaccines | Plant lipids | Vaccination | Trehalose | Helper cells | Intracellular signalling | Activation | Lymphocytes T | Interleukin 1 receptors | Cord factor | Experiments | Signal transduction | Immunology | Lymphocytes | Interleukin 1 | Immunoglobulins | Immune response | Cytokines | Neutrophils | Adjuvanticity | Interleukin 17 | Interleukin 18 | Infectious diseases | Hospitals | Tuberculosis | Glycolipids | Antigen-presenting cells | γ-Interferon | MyD88 protein | Syk protein | Hygiene | Index Medicus
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 05/2013, Volume 190, Issue 9, pp. 4692 - 4706
Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores... 
Life Sciences & Biomedicine | Immunology | Science & Technology | NIH 3T3 Cells | Oncogene Proteins - genetics | Cytoskeletal Proteins - genetics | Cytoskeleton - immunology | Acute-Phase Proteins - genetics | Phagocytosis - genetics | Respiratory Burst - immunology | Bacterial Infections - genetics | Disease Susceptibility - immunology | Bacterial Infections - immunology | Lipocalins - genetics | Cytoskeletal Proteins - metabolism | rho GTP-Binding Proteins - immunology | Chemotaxis - immunology | Neutrophils - metabolism | Oncogene Proteins - immunology | Chemokines - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Siderophores - metabolism | rho GTP-Binding Proteins - genetics | Mice, Inbred C57BL | Cytoskeleton - genetics | Neutrophils - immunology | Oncogene Proteins - metabolism | Phagocytosis - immunology | Chemokines - genetics | Chemotaxis - genetics | Mice, Knockout | Animals | Cytoskeletal Proteins - immunology | Lipocalin-2 | Lipocalins - immunology | rho GTP-Binding Proteins - metabolism | Cytoskeleton - metabolism | Chemokines - metabolism | Mice | MicroRNAs - genetics | Respiratory Burst - genetics | Siderophores - immunology | Acute-Phase Proteins - immunology | Bacterial Infections - metabolism | Index Medicus | Abridged Index Medicus | Candida albicans | Listeria monocytogenes | neutrophils | Lipocalin 24p3 | Staphylococcus aureus
Journal Article