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Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 738 - 748
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 236 - 246
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying... 
KIDNEY-DISEASE | NEPHROLITHIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | DANGER | ACTIVATION | DENDRITIC CELLS | NLRP3 INFLAMMASOME | STONE FORMATION | FAILURE | NEPHROPATHY | NALP3 INFLAMMASOME | Interleukin-18 - immunology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Nephrocalcinosis - immunology | Receptors, Interleukin-1 - genetics | Interleukin-1beta - genetics | Inflammation - metabolism | Nephrocalcinosis - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Kidney Tubules - pathology | Immunologic Deficiency Syndromes - immunology | Kidney Tubules - metabolism | Carrier Proteins - immunology | Dendritic Cells - metabolism | Interleukin-1beta - secretion | Kidney Tubules - immunology | Calcium Oxalate - immunology | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Interleukin-1beta - immunology | Inflammation - immunology | Calcium Oxalate - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Carrier Proteins - genetics | Nephrocalcinosis - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Nephrocalcinosis - genetics | CARD Signaling Adaptor Proteins | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Inflammation - genetics | Mice | Interleukin-18 - genetics | Myeloid Differentiation Factor 88 - metabolism | Interleukin-18 - metabolism | Phagocytosis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, p. e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2009, Volume 86, Issue 4, pp. 863 - 875
Endotoxin tolerance interferes with TLR4 signalosome assembly, kinase/transcription factor activation, and increases negative TLR pathway regulators. Endotoxin... 
monocytes/macrophages | lipopolysaccharide | signal transduction | suppression/anergy | cell activation | Lipopolysaccharide | Signal transduction | Cell activation | Monocytes/macrophages | Suppression/anergy | STRANDED-RNA | ACTIVATION | DOWN-REGULATION | NECROSIS-FACTOR-ALPHA | BACTERIAL FLAGELLIN | IMMUNOLOGY | CUTTING EDGE | CELL BIOLOGY | RECEPTOR-ASSOCIATED KINASE | TOLL-LIKE RECEPTORS | HEMATOLOGY | NF-KAPPA-B | INNATE IMMUNITY | Protein Kinase C - genetics | Cytoskeletal Proteins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Suppressor of Cytokine Signaling 1 Protein | Monocytes - metabolism | Monocytes - immunology | Armadillo Domain Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Regulatory Factor-3 - genetics | Lipopolysaccharides - immunology | Signal Transduction - immunology | Protein Kinase C - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | Cytokines - metabolism | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Myeloid Differentiation Factor 88 - genetics | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Protein Kinase C - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Adaptor Proteins, Vesicular Transport - immunology | Armadillo Domain Proteins - immunology | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Armadillo Domain Proteins - metabolism | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Suppressor of Cytokine Signaling Proteins - metabolism | Myeloid Differentiation Factor 88 - metabolism | monocytes | macrophages | suppression | Receptors, Signal Transduction, & Genes | anergy
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 250 - 258
Journal Article
Journal Article