X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (36263) 36263
Publication (3395) 3395
Book Review (400) 400
Book Chapter (217) 217
Dissertation (94) 94
Conference Proceeding (72) 72
Book / eBook (66) 66
Web Resource (13) 13
Data Set (10) 10
Magazine Article (8) 8
Government Document (3) 3
Paper (3) 3
Reference (2) 2
Presentation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (17564) 17564
animals (14676) 14676
t-lymphocytes, cytotoxic - immunology (11760) 11760
index medicus (11505) 11505
mice (10135) 10135
immunology (8603) 8603
cytotoxic activity (7028) 7028
female (6562) 6562
male (4539) 4539
cancer (4394) 4394
oncology (4287) 4287
cell line, tumor (3846) 3846
biochemistry & molecular biology (3759) 3759
cytotoxicity (3742) 3742
chemistry, medicinal (3674) 3674
immunotherapy (3450) 3450
mice, inbred c57bl (3413) 3413
t cells (3408) 3408
apoptosis (3165) 3165
pharmacology & pharmacy (3139) 3139
cytotoxicity, immunologic (3106) 3106
lymphocytes (3024) 3024
dendritic cells (2985) 2985
cytotoxic t-lymphocytes (2792) 2792
mice, inbred balb c (2772) 2772
analysis (2636) 2636
expression (2530) 2530
medicine, research & experimental (2388) 2388
cell biology (2364) 2364
cell line (2264) 2264
research (2207) 2207
cells, cultured (2200) 2200
adult (2168) 2168
antineoplastic agents - pharmacology (2168) 2168
lymphocyte activation (2144) 2144
in-vitro (2058) 2058
antigens (2056) 2056
cytotoxic (2043) 2043
killer cells, natural - immunology (2037) 2037
cd8-positive t-lymphocytes - immunology (2019) 2019
cells (2012) 2012
middle aged (1934) 1934
flow cytometry (1922) 1922
chemistry, multidisciplinary (1912) 1912
in-vivo (1910) 1910
tumor cells, cultured (1856) 1856
dendritic cells - immunology (1837) 1837
health aspects (1737) 1737
chemistry, organic (1736) 1736
proteins (1729) 1729
tumors (1655) 1655
molecular structure (1653) 1653
t-lymphocytes - immunology (1631) 1631
molecular sequence data (1607) 1607
vaccination (1604) 1604
amino acid sequence (1596) 1596
article (1576) 1576
structure-activity relationship (1545) 1545
activation (1541) 1541
research article (1539) 1539
t-lymphocytes, cytotoxic - metabolism (1536) 1536
care and treatment (1513) 1513
derivatives (1458) 1458
vaccines (1413) 1413
antineoplastic agents - chemistry (1409) 1409
t-lymphocytes, cytotoxic - drug effects (1404) 1404
peptides (1400) 1400
perforin (1385) 1385
immunization (1371) 1371
antigen (1355) 1355
hematology (1347) 1347
drug screening assays, antitumor (1331) 1331
plant sciences (1264) 1264
t-cells (1261) 1261
aged (1259) 1259
cd4-positive t-lymphocytes - immunology (1250) 1250
microbiology (1243) 1243
virology (1242) 1242
multidisciplinary sciences (1237) 1237
immune response (1221) 1221
cell proliferation - drug effects (1220) 1220
medicine (1219) 1219
induction (1211) 1211
infection (1207) 1207
lymphocytes t (1189) 1189
immunity (1185) 1185
responses (1185) 1185
antigens, neoplasm - immunology (1178) 1178
cell survival - drug effects (1176) 1176
biotechnology & applied microbiology (1161) 1161
immune system (1139) 1139
rats (1121) 1121
cytokines (1114) 1114
melanoma (1096) 1096
chemotherapy (1082) 1082
gene expression (1068) 1068
physiological aspects (1045) 1045
identification (1035) 1035
pore forming cytotoxic proteins (1033) 1033
biology (1025) 1025
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (35) 35
Collection Dvlpm't (Acquisitions) - Vendor file (7) 7
Collection Dvlpm't (Acquisitions) - Closed Orders (5) 5
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (4) 4
UofT at Mississauga - Stacks (3) 3
Online Resources - Online (2) 2
Chemistry (A D Allen) - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (35819) 35819
Japanese (286) 286
Chinese (224) 224
Russian (80) 80
French (55) 55
German (52) 52
Korean (45) 45
Portuguese (26) 26
Polish (9) 9
Persian (8) 8
Spanish (8) 8
Arabic (4) 4
Croatian (4) 4
Indonesian (4) 4
Hungarian (3) 3
Swedish (3) 3
Italian (2) 2
Slovak (2) 2
Belarusian (1) 1
Malay (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Drug Design, Development and Therapy, ISSN 1177-8881, 06/2017, Volume 11, pp. 1891 - 1904
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3' ,4' )-(-)- -khellactones. The newly... 
4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(-)-cis-khellactones | Synthesis | Apoptosis | Cytotoxic activity | Antineoplastic Agents, Phytogenic - chemical synthesis | Magnetic Resonance Spectroscopy | Apoptosis - drug effects | Humans | Structure-Activity Relationship | Membrane Potential, Mitochondrial - drug effects | Coumarins - pharmacology | Tetrazolium Salts | Tandem Mass Spectrometry | Signal Transduction - drug effects | Coumarins - chemical synthesis | Thiazoles | Cell Line, Tumor | Caspases - drug effects | Enzyme Activation | Antineoplastic Agents, Phytogenic - pharmacology | Drug Screening Assays, Antitumor | Drugs | Care and treatment | Usage | Structure-activity relationship (Pharmacology) | Development and progression | Hepatoma | Structure-activity relationships | Health aspects | Testing | Lactones | Nuclear magnetic resonance--NMR | Toxicity | Liver | Staining | Cytotoxicity | Propidium iodide | Caspase-3 | Anticancer properties | Substitutes | Mitochondria | Membrane potential | Colon | Gastric cancer | Magnetic induction | Iodides | Caspase | Data processing | Mass spectroscopy | Derivatives | Caspase-9 | Annexin V | Mass spectrometry | Cancer | Values | Cancer therapies | Chinese medicine | Acquired immune deficiency syndrome--AIDS | Energy dissipation | Human immunodeficiency virus--HIV | Pharmaceutical sciences | Glycoproteins | Chromatography | Chemistry | Chemotherapy | Potassium | synthesis | 4-methoxy-substituted and 5-methyl-substituted (3'S | apoptosis | cytotoxic activity | 4'S)-(-)-cis-khellactones
Journal Article
European Journal of Immunology, ISSN 0014-2980, 07/2009, Volume 39, Issue 7, pp. 1716 - 1725
Activation of naive CD8+ T cells with antigen in the absence of skewing cytokines triggers their differentiation into effector CTL, which induces death of... 
EAE | Tc17 | CTL | STAT3 | RORγt | TGF-BETA | INTERFERON-REGULATORY FACTOR-4 | ROR gamma t | IMMUNOLOGY | IL-21 | EFFECTOR | ROR-GAMMA | EOMESODERMIN | GENERATION | DIFFERENTIATION | T-H-17 CELLS | T-CELLS | CD8-Positive T-Lymphocytes - cytology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Gene Expression - drug effects | Granzymes - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Green Fluorescent Proteins - genetics | Interferon-gamma - metabolism | Receptors, Retinoic Acid - genetics | Cell Differentiation - genetics | Flow Cytometry | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukins - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 | T-Lymphocytes, Cytotoxic - immunology | Green Fluorescent Proteins - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Receptors, Retinoic Acid - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Thyroid Hormone - metabolism | Cell Differentiation - immunology | Interleukin-17 - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-6 - pharmacology | T-Lymphocytes, Cytotoxic - metabolism | Cell Differentiation - drug effects | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | T-Lymphocytes, Cytotoxic - cytology
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 758 - 777
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 8/2012, Volume 21, Issue 8, pp. 2123 - 2132
In the last few decades, a lot of work has been done on thiazole ring to find new compounds related to this scaffold to act as antioxidant, analgesic,... 
Biochemistry, general | Neuroprotective | Biomedicine | Pharmacology/Toxicology | Cytotoxic | Antioxidant | Thiazole | Thiamine | Cell Biology | ANTIOXIDANT ACTIVITY | CHEMISTRY, MEDICINAL | ANTIBACTERIAL | ANTITUMOR-ACTIVITY | 2,4-DISUBSTITUTED THIAZOLES | POTENT | AGENTS | ANTIFUNGAL | INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | Antioxidants | Diuretics | Antiviral agents | Analgesics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2777 - 2790
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b(+) myeloid... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYELOID SUPPRESSOR-CELLS | RESPONSES | GROWTH-FACTOR-BETA | COLONY-STIMULATING FACTOR | MECHANISM | MACROPHAGES | RECEPTOR EXPRESSION | IMMUNE DYSFUNCTION | NITRIC-OXIDE | CANCER | Neoplasms - metabolism | Spleen - immunology | Gene Expression - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, Cell Surface - analysis | Arginase - metabolism | Monocytes - metabolism | Monocytes - immunology | Interferon-gamma - metabolism | Lymphocyte Activation - immunology | CD11b Antigen - analysis | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | Myeloid Cells - drug effects | Interferon-gamma - genetics | Interleukin-4 - genetics | T-Lymphocytes, Cytotoxic - immunology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | Arginase - genetics | Spleen - cytology | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Monocytes - drug effects | Immunity, Cellular - immunology | Models, Immunological | Animals | Nitric Oxide Synthase Type II - genetics | T-Lymphocytes, Cytotoxic - metabolism | Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Interferon-gamma - pharmacology | Nitric Oxide Synthase Type II - metabolism | Receptors, Cell Surface - genetics | Medicine, Experimental | Medical research | Care and treatment | Research | T cells | Tumors
Journal Article
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 12/2018, Volume 27, Issue 11, pp. 2414 - 2425
Chalcones are a group of molecules with a broad spectrum of biological activities, being especially appealing for their antiproliferative effects on several... 
Biochemistry, general | SH-SY5Y | Chalcones | Biomedicine | Antiproliferative activity | Neuroblastoma | Pharmacology/Toxicology | Cell Biology | 2D-QSAR | Cancer | SUBSTITUTED CHALCONES | CANCER-CELLS | DESIGN | CHEMISTRY, MEDICINAL | ANALOGS | ANTIOXIDANT ACTIVITIES | CYTOTOXIC ACTIVITY | ALDOL CONDENSATION | ANTICANCER | QSAR | DERIVATIVES | Analysis | Resveratrol
Journal Article