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Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. e498 - e509
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6226 - 6233
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2007, Volume 111, Issue 2, pp. 219 - 226
The present study was designed to determine in vivo efficacy of polysaccharides ( -PS) for enhancing the activity of immunological effector cells in... 
Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ling Zhi) | Cytotoxicity | Cyclophosphamide | Immunomodulation | Polysaccharide | immunomodulation | NKT CELLS | NATURAL-KILLER | CHEMISTRY, MEDICINAL | polysaccharide | MACROPHAGES | IMMUNE FUNCTIONS | Ganoderma lucidum (Leyss. ex Fr.) karst. (Ling Zhi) | CANCER | ANTITUMOR | LYMPHOCYTE-PROLIFERATION | PLANT SCIENCES | RECOVERY | INTEGRATIVE & COMPLEMENTARY MEDICINE | cyclophosphamide | PHARMACOLOGY & PHARMACY | cytotoxicity | LEVAMISOLE | Dose-Response Relationship, Immunologic | Mitogens - pharmacology | Concanavalin A - pharmacology | Cell Count | Male | Spleen - drug effects | T-Lymphocytes, Cytotoxic - drug effects | Time Factors | Polysaccharides - isolation & purification | Killer Cells, Natural - immunology | Bone Marrow Cells - drug effects | Polysaccharides - administration & dosage | Leukocyte Count | Reishi - chemistry | Cytotoxicity, Immunologic - drug effects | Macrophages, Peritoneal - drug effects | T-Lymphocytes, Cytotoxic - immunology | Phagocytosis - drug effects | Mice, Inbred C57BL | Cells, Cultured | Injections, Intraperitoneal | Polysaccharides - adverse effects | B-Lymphocytes - physiology | Spleen - cytology | Immunosuppressive Agents - toxicity | Polysaccharides - pharmacology | T-Lymphocytes, Cytotoxic - physiology | Erythrocytes - drug effects | B-Lymphocytes - drug effects | Immunosuppression | Killer Cells, Lymphokine-Activated - immunology | Animals | B-Lymphocytes - immunology | Leukocytes - drug effects | Cell Proliferation - drug effects | Cyclophosphamide - toxicity | Killer Cells, Natural - drug effects | Mice | Erythrocyte Count | Killer Cells, Lymphokine-Activated - cytology
Journal Article
Immunity, ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 632 - 642
Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the... 
MOLIMMUNO | CELLIMMUNO | TARGET-CELL | SUPRAMOLECULAR ACTIVATION CLUSTERS | RING JUNCTION | EFFECTOR FUNCTIONS | MICROTUBULE-ORGANIZING CENTER | CLASS-I | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | EX-VIVO | POLARIZATION | LYMPHOCYTES-T | Calcium - metabolism | Humans | Calcium - immunology | Microtubule-Organizing Center - drug effects | Immunological Synapses - metabolism | Receptors, Antigen, T-Cell - drug effects | Signal Transduction - immunology | T-Lymphocytes, Cytotoxic - drug effects | Microtubules - metabolism | Microtubules - drug effects | Cytoplasmic Granules - metabolism | Calcium Signaling - immunology | Receptors, Antigen, T-Cell - immunology | Biological Transport - drug effects | Cell Polarity - drug effects | Cytotoxicity, Immunologic - drug effects | Ionophores - pharmacology | Microtubule-Organizing Center - metabolism | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Cell Polarity - immunology | Receptors, Antigen, T-Cell - metabolism | Cytoplasmic Granules - drug effects | Microtubules - immunology | Biological Transport - immunology | Cell Degranulation - immunology | Immunological Synapses - drug effects | Microtubule-Organizing Center - immunology | Signal Transduction - drug effects | T-Lymphocytes, Cytotoxic - metabolism | Calcium Signaling - drug effects | Immunological Synapses - immunology | Ionomycin - pharmacology | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | T-Lymphocytes, Cytotoxic - cytology | Cell Degranulation - drug effects | T cells | Ligands | T cell receptors | Peptides | Efficiency
Journal Article
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 07/2016, Volume 13, Issue 7, pp. 431 - 446
Around 15 years ago, imatinib mesylate (Gleevec (R) or Glivec (R), Novartis, Switzerland) became the very first 'targeted' anticancer drug to be clinically... 
CHRONIC MYELOGENOUS LEUKEMIA | CYTOTOXIC T-CELLS | KILLER DENDRITIC CELLS | ONCOLOGY | COMPLETE MOLECULAR REMISSION | MINOR HISTOCOMPATIBILITY ANTIGENS | ACUTE LYMPHOBLASTIC-LEUKEMIA | TYROSINE KINASE INHIBITOR | PATIENTS RECEIVING IMATINIB | GASTROINTESTINAL STROMAL TUMORS | CHRONIC MYELOID-LEUKEMIA | Tumor Escape - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Antineoplastic Agents - therapeutic use | B7 Antigens - immunology | Drug Approval | Protein-Tyrosine Kinases - immunology | Hematopoiesis - drug effects | Natural Cytotoxicity Triggering Receptor 3 - drug effects | Imatinib Mesylate - therapeutic use | Immunity, Cellular - drug effects | Immune Tolerance - immunology | T-Lymphocytes - drug effects | Protein-Tyrosine Kinases - drug effects | Killer Cells, Natural - immunology | Molecular Chaperones - drug effects | Natural Cytotoxicity Triggering Receptor 3 - immunology | Vascular Endothelial Growth Factor A - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology | Molecular Chaperones - immunology | Molecular Targeted Therapy - methods | Gastrointestinal Stromal Tumors - immunology | Immune Tolerance - drug effects | Tumor Escape - immunology | Antigens, Neoplasm - immunology | Antineoplastic Agents - immunology | B7 Antigens - drug effects | Vascular Endothelial Growth Factor A - immunology | Immunologic Surveillance - drug effects | Forecasting | Immunologic Surveillance - immunology | Hematopoiesis - immunology | Imatinib Mesylate - immunology | Gastrointestinal Stromal Tumors - drug therapy | T-Lymphocytes - immunology | Killer Cells, Natural - drug effects | Antigens, Neoplasm - drug effects | Tyrosine | Care and treatment | Analysis | Immunotherapy | B cells | Drug approval | Cancer
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3718 - 3730
A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as cytotoxic T lymphocyte-associated protein 4... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | LYMPHOCYTE ANTIGEN-4 | PHOSPHATIDYLINOSITOL 3-KINASE | IN-VIVO | COMBINATION IMMUNOTHERAPY | TUMOR-CELLS | NKG2D RECEPTOR | IMMUNOLOGICAL SYNAPSE | STOP-SIGNAL | Mammary Neoplasms, Experimental - immunology | Nucleocytoplasmic Transport Proteins - biosynthesis | NK Cell Lectin-Like Receptor Subfamily K - immunology | Antibodies, Monoclonal - therapeutic use | Cell Line, Tumor - transplantation | CD8-Positive T-Lymphocytes - radiation effects | Immunotherapy | Intercellular Adhesion Molecule-1 - biosynthesis | Female | Mammary Neoplasms, Experimental - secondary | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Cytotoxicity, Immunologic - drug effects | Neoplasm Proteins - biosynthesis | Receptors, CXCR - genetics | Antibodies, Monoclonal - pharmacology | Mammary Neoplasms, Experimental - radiotherapy | Combined Modality Therapy | Lymphocytes, Tumor-Infiltrating - drug effects | Nucleocytoplasmic Transport Proteins - genetics | Mammary Neoplasms, Experimental - therapy | Tumor Microenvironment - immunology | H-2 Antigens - immunology | Animals | NK Cell Lectin-Like Receptor Subfamily K - antagonists & inhibitors | Nuclear Matrix-Associated Proteins - genetics | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor - immunology | Intercellular Adhesion Molecule-1 - genetics | Gene Expression Regulation, Neoplastic - radiation effects | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Nuclear Matrix-Associated Proteins - biosynthesis | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Cell Movement | Drug Screening Assays, Antitumor | Lymphocytes, Tumor-Infiltrating - immunology | Receptors, CXCR6 | Care and treatment | Tumor-infiltrating lymphocytes | Physiological aspects | Research | T cells | Health aspects | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40677
Background: Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on... 
MHC CLASS-I | DENDRITIC CELLS | NK CELLS | MECHANISM | TUMOR-ANTIGENS | TOLERANCE | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | ANERGY | INDUCTION | CYTOTOXIC T-LYMPHOCYTES | Spleen - immunology | Ovalbumin - immunology | Apoptosis - drug effects | Vaccination | Carcinoma, Lewis Lung - immunology | Antineoplastic Agents - therapeutic use | Spleen - drug effects | Carcinoma, Lewis Lung - blood supply | Neoplasm Metastasis | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Angiogenesis Inhibitors - therapeutic use | Biomarkers, Tumor - metabolism | Killer Cells, Natural - immunology | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | Cytotoxicity, Immunologic - drug effects | Disease Models, Animal | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Angiogenesis Inhibitors - pharmacology | Treatment Outcome | Tumor Burden | Cell Adhesion - drug effects | Antigen-Presenting Cells - immunology | Carcinoma, Lewis Lung - drug therapy | Animals | Carcinoma, Lewis Lung - pathology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Myeloid Cells - pathology | Antigens | Lymphocytes | Lung cancer | Comparative analysis | Health aspects | Vascular endothelial growth factor | Tumors | Regulators | Animal models | Leukocyte migration | Laboratories | Veterans | CD8 antigen | Immunocytochemistry | Cytotoxicity | Lymphocytes T | Suppressor cells | Anticancer properties | Angiogenesis | Cell activation | Immunology | Immunotherapy | Bone marrow | Perforin | Medical research | Immunological memory | Immune response | Inflammation | CD3 antigen | T cell receptors | CXCR3 protein | Adenomatous polyposis coli | Medicine | Depletion | Antigen-presenting cells | γ-Interferon | CXCL10 protein | Interleukin 10 | Antitumor activity | Lymphomas | Cell migration | Apoptosis | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2796 - 2801
Retrospective clinical studies have used immune-based biomarkers, alone or in combination, to predict survival outcomes for women with breast cancer (BC);... 
T lymphocytes | Cytometry | Lymphocytes | Breasts | BREAST CANCER SPECIAL FEATURE | Residual neoplasm | Breast cancer | Leukocytes | Macrophages | Tumors | Cancer | Inflammation | Macrophage | INFILTRATING LYMPHOCYTES | MULTIDISCIPLINARY SCIENCES | VEGF EXPRESSION | macrophage | MICROVESSEL DENSITY | MAMMARY-TUMORS | inflammation | MOUSE MODEL | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | CARCINOMA | PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | Neoplasm, Residual - pathology | Leukocytes - pathology | Breast Neoplasms - immunology | Humans | Antineoplastic Agents - therapeutic use | Cell Lineage - drug effects | Antigens, CD - metabolism | Leukocytes - immunology | Lymphocyte Activation - immunology | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Biomarkers, Tumor - metabolism | Female | Myeloid Cells - drug effects | Neoadjuvant Therapy | Neoplasm, Residual - immunology | Antineoplastic Agents - pharmacology | T-Lymphocytes - pathology | Cytotoxicity, Immunologic - drug effects | Lymphocytes, Tumor-Infiltrating - drug effects | Breast Neoplasms - drug therapy | Cell Movement - drug effects | Phenotype | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Lymphocyte Activation - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | Leukocytes - drug effects | T-Lymphocytes - immunology | Myeloid Cells - pathology | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | Development and progression | Health aspects | Biological Sciences
Journal Article