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1. Full Text Candidalysin is a fungal peptide toxin critical for mucosal infection
by Moyes, David L and Wilson, Duncan and Richardson, Jonathan P and Mogavero, Selene and Tang, Shirley X and Wernecke, Julia and Höfs, Sarah and Gratacap, Remi L and Robbins, Jon and Runglall, Manohursingh and Murciano, Celia and Blagojevic, Mariana and Thavaraj, Selvam and Förster, Toni M and Hebecker, Betty and Kasper, Lydia and Vizcay, Gema and Iancu, Simona I and Kichik, Nessim and Häder, Antje and Kurzai, Oliver and Luo, Ting and Krüger, Thomas and Kniemeyer, Olaf and Cota, Ernesto and Bader, Oliver and Wheeler, Robert T and Gutsmann, Thomas and Hube, Bernhard and Naglik, Julian R
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7597, pp. 64 - 68
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells... 
PATHOGENICITY MECHANISMS | BETA-MANNOSYLATION | PROTEIN-KINASE HOMOLOG | OROPHARYNGEAL CANDIDIASIS | EPITHELIAL-CELLS | FILAMENTOUS GROWTH | MULTIDISCIPLINARY SCIENCES | HYPHAL DEVELOPMENT | ALBICANS ENCODES | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | Virulence - drug effects | Virulence Factors - genetics | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Fungal Proteins - toxicity | Candida albicans - metabolism | Cytotoxins - secretion | Candidiasis - microbiology | Cytotoxins - toxicity | Host-Pathogen Interactions - immunology | Cytotoxins - metabolism | Mycotoxins - metabolism | Mycotoxins - genetics | Candidiasis - pathology | Virulence Factors - toxicity | Candida albicans - pathogenicity | Mycotoxins - secretion | Epithelial Cells - pathology | Fungal Proteins - genetics | Candida albicans - immunology | Mycotoxins - toxicity | Candidiasis - metabolism | Mucous Membrane - pathology | Signal Transduction - drug effects | Cell Membrane Permeability - drug effects | Epithelial Cells - immunology | Fungal Proteins - secretion | Virulence Factors - metabolism | Cytotoxins - genetics | Mucous Membrane - microbiology | Fungal Proteins - metabolism | Candida albicans | Fungi | Physiological aspects | Mucous membrane | Proteins | Yeast | Peptides | Cytokines | Pathogenesis | Toxins | Fungal infections | Index Medicus
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2. Full Text Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents
by Lo, Kenneth Kam-Wing
Accounts of Chemical Research, ISSN 0001-4842, 07/2015, Volume 48, Issue 12, pp. 2985 - 2995
Although the interactions of transition metal complexes with biological molecules have been extensively studied, the use of luminescent transition metal... 
ELECTROCHEMICAL PROPERTIES | CYCLOMETALATED IRIDIUM(III) | CRYSTAL-STRUCTURE | BIOTIN COMPLEXES | LABELING REAGENTS | NITRIC-OXIDE | PROTEIN-BINDING PROPERTIES | EMISSIVE BEHAVIOR | CHEMISTRY, MULTIDISCIPLINARY | MULTICOLOR PHOSPHORESCENCE SYNTHESIS | CELLULAR UPTAKE | Cell Survival - drug effects | Luminescent Agents - pharmacology | Luminescent Agents - chemistry | Pyridines - chemistry | Humans | Luminescence | Animals | Cytotoxins - pharmacology | Cytotoxins - radiation effects | Cytotoxins - chemistry | Indicators and Reagents | Organometallic Compounds - chemistry | Mice | Rhenium - chemistry | HeLa Cells | Iridium - chemistry | Organometallic Compounds - pharmacology | Index Medicus | Uptakes | Cellular | Transition metals | Medical imaging | Sensors | Biological | Coordination compounds | Functional groups
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3. Full Text Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways
by Xia, Tian and Kovochich, Michael and Liong, Monty and Zink, Jeffrey I and Nel, Andre E
ACS Nano, ISSN 1936-0851, 01/2008, Volume 2, Issue 1, pp. 85 - 96
The exponential increase in the number of new nanomaterials that are being produced increases the likelihood of adverse biological effects in humans and the... 
Endocytosis mitochondria | Cell death | Nanotoxicology | Cationic nanoparticle | DIESEL EXHAUST PARTICLES | APOPTOSIS | cell death | mitochondria | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOSCIENCE & NANOTECHNOLOGY | DEATH | POLYETHYLENIMINE | CHEMISTRY, MULTIDISCIPLINARY | PERMEABILITY TRANSITION | NANOPARTICLES | GENE | AMINO-ACIDS | endocytosis | CAVEOLAE | cationic nanoparticle | nanotoxicology | Amines - chemistry | Calcium - metabolism | Humans | Nanospheres - chemistry | Pneumonia - pathology | Caveolae - drug effects | Polystyrenes - toxicity | Cytotoxins - toxicity | beta-Cyclodextrins - pharmacology | Polystyrenes - chemistry | Endocytosis | Lysosomes - metabolism | Nanospheres - adverse effects | Pneumonia - chemically induced | Cytotoxins - metabolism | Macrolides - pharmacology | Cytotoxins - antagonists & inhibitors | Polystyrenes - antagonists & inhibitors | Lysosomes - drug effects | Cell Line | Fluorescent Dyes - chemistry | Permeability - drug effects | Intracellular Space - drug effects | Caveolae - metabolism | Polystyrenes - metabolism | Mitochondria - metabolism | Nanospheres - toxicity | Mitochondria - drug effects | Mitochondria - pathology | Organ Specificity | Intracellular Space - ultrastructure | Animals | Intracellular Space - metabolism | Cytotoxins - chemistry | Mice | Index Medicus
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4. Full Text Impact of silica nanoparticle design on cellular toxicity and hemolytic activity
by Yu, Tian and Malugin, Alexander and Ghandehari, Hamidreza
ACS Nano, ISSN 1936-0851, 07/2011, Volume 5, Issue 7, pp. 5717 - 5728
Understanding the toxicity of silica nanoparticles (SiO2) on the cellular level is crucial for rational design of these nanomaterials for biomedical... 
porous SiO | nanomedicine | nanotoxicity | silica nanorods | silica | BIOCOMPATIBILITY | SURFACE FUNCTIONALIZATION | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | SIZE | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | NANORODS | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | DELIVERY | MORPHOLOGY CONTROL | NANOTUBES | porous SiO2 | CYTOTOXICITY | Amines - chemistry | Hemolysis - drug effects | Cell Line | Silanes - chemistry | Nanoparticles - chemistry | Humans | Silicon Dioxide - chemistry | Materials Testing | Cytotoxins - toxicity | Nanoparticles - toxicity | Erythrocytes - drug effects | Silicon Dioxide - metabolism | Animals | Silicon Dioxide - toxicity | Surface Properties | Cytotoxins - chemistry | Cytotoxins - metabolism | Cell Proliferation - drug effects | Mice | Porosity | Cell Membrane - drug effects | Cellular | Nanospheres | Toxicity | Biocompatibility | Nanostructure | Aspect ratio | Silicon dioxide | Index Medicus | Silica
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5. Full Text Structure of Tracheal Cytotoxin in Complex with a Heterodimeric Pattern-Recognition Receptor
by Chung-I Chang and Yogarany Chelliah and Dominika Borek and Dominique Mengin-Lecreulx and Johann Deisenhofer and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science, ISSN 0036-8075, 3/2006, Volume 311, Issue 5768, pp. 1761 - 1764
Tracheal cytotoxin (TCT), a naturally occurring fragment of Gram-negative peptidoglycan, is a potent elicitor of innate immune responses in Drosophila. It... 
Cytotoxins | Molecules | Receptors | Oxygen | Hydrogen bonds | Disaccharides | Amino acids | Ligands | Reports | Biochemistry | Physiological immunosuppression | ANGSTROM RESOLUTION | PEPTIDOGLYCAN-RECOGNITION | IMMUNE-SYSTEM | DROSOPHILA-MELANOGASTER | PATHWAY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PROTEINS | Peptidoglycan - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Peptidoglycan - chemistry | Crystallization | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Animals | Carrier Proteins - metabolism | Hydrogen Bonding | Cytotoxins - chemistry | Cytotoxins - metabolism | Hydrophobic and Hydrophilic Interactions | Carrier Proteins - chemistry | Protein Conformation | Drosophila melanogaster | Research | Structure | Trachea | Analysis | Drosophila | Peptidoglycans | Proteins | Bacteria | Toxins | Insects | Crystal structure | Index Medicus
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6. Full Text Insights into the cellular response triggered by silver nanoparticles using quantitative proteomics
by Verano-Braga, Thiago and Miethling-Graff, Rona and Wojdyla, Katarzyna and Rogowska-Wrzesinska, Adelina and Brewer, Jonathan R and Erdmann, Helmut and Kjeldsen, Frank
ACS Nano, ISSN 1936-0851, 03/2014, Volume 8, Issue 3, pp. 2161 - 2175
The use of nanoparticles in foods, materials, and clinical treatments has increased dramatically in the past decade. Because of the possibility of human... 
sumoylation | proteomics | silver nanoparticles | ubiquitination | iTRAQ | mass spectrometry | cytotoxicity | CELLS | ACTIVATION | MECHANISM | SAMPLE PREPARATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | TOXICITY | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | GENOTOXICITY | MEDIATED ENDOCYTOSIS | ENHANCEMENT | Cell Line | Humans | Silver - chemistry | Cytotoxins - toxicity | Particle Size | Metal Nanoparticles - toxicity | Biological Transport | Cytotoxins - chemistry | Proteomics | Cytotoxins - metabolism | Silver - toxicity | Oxidative Stress - drug effects | Silver - metabolism | Index Medicus | Human | Proteins | Nanoparticles | Silver | Cellular | Medical services | Nanostructure | Kinases
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7. Full Text Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
by Bolton, Judy L and Bolton, Judy L and Dunlap, Tareisha and Dunlap, Tareisha
Chemical research in toxicology, ISSN 0893-228X, 2017, Volume 30, Issue 1, pp. 13 - 37
Quinones represent a class of toxicological intermediates, which can create a variety of hazardous effects in vivo including, acute cytotoxicity,... 
CHEMISTRY, MEDICINAL | OXIDATIVE DNA-DAMAGE | SINGLE-STRAND BREAKS | CATECHOL ESTROGEN 4-HYDROXYEQUILENIN | ALDO-KETO-REDUCTASES | POTENTIAL BIOACTIVATION MECHANISM | HUMAN LIVER-MICROSOMES | HORMONE REPLACEMENT THERAPY | CHEMISTRY, MULTIDISCIPLINARY | S-TRANSFERASE P1-1 | RECEPTOR MODULATOR SERM | TOXICOLOGY | NF-KAPPA-B | Animals | Cytotoxins - pharmacology | Quinones - chemistry | Humans | Quinones - toxicity | Cytotoxins - chemistry | Cytotoxins - toxicity | Quinones - pharmacology | Cytoprotection | Index Medicus
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8. Full Text Fidaxomicin Preserves the Intestinal Microbiome During and After Treatment of Clostridium difficile Infection (CDI) and Reduces Both Toxin Reexpression and Recurrence of CDI
by Thomas J. Louie and Kris Cannon and Brendan Byrne and Judy Emery and Linda Ward and Melissa Eyben and Walter Krulicki
Clinical Infectious Diseases, ISSN 1058-4838, 8/2012, Volume 55, Issue 2, pp. S132 - S142
The microflora-sparing properties of fidaxomicin were examined during the conduct of a randomized clinical trial comparing vancomycin 125 mg 4 times per day... 
Clostridium | Polymerase chain reaction | Microorganisms | Microbiota | Antibiotics | Clostridium difficile | Infections | Toxins | Prevotella | Bacteroides | INFECTIOUS DISEASES | BACTERIA | DIARRHEA | FECAL MICROBIOTA | PRIMERS | MICROBIOLOGY | IMMUNOLOGY | OPT-80 | REAL-TIME PCR | VANCOMYCIN | DISEASE | ANTIBIOTIC-TREATMENT | METRONIDAZOLE | Humans | RNA, Ribosomal, 16S - analysis | Clostridium difficile - genetics | Secondary Prevention | Anti-Bacterial Agents - therapeutic use | Cytotoxins - analysis | Feces - microbiology | Clostridium Infections - microbiology | Aminoglycosides - administration & dosage | Cytotoxins - metabolism | DNA, Bacterial - analysis | Real-Time Polymerase Chain Reaction | Limit of Detection | Vancomycin - administration & dosage | Bacterial Toxins - analysis | Double-Blind Method | Bacterial Load | Clostridium difficile - pathogenicity | Bacterial Toxins - metabolism | DNA, Bacterial - genetics | Intestines - microbiology | Vancomycin - therapeutic use | RNA, Ribosomal, 16S - genetics | Clostridium Infections - drug therapy | Gene Expression Regulation, Bacterial | Metagenome | Clostridium difficile - drug effects | Aminoglycosides - therapeutic use | Clinical trials | Bacterial infections | Comparative analysis | Medical treatment | Index Medicus | Preservation | Microflora | Population studies | Colony-forming cells | Vancomycin | Infection | Cytotoxins | Intestine | Primers | Supplement
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9. Full Text A new cytotoxin from Bacillus cereus that may cause necrotic enteritis
by Lund, Terje and De Buyser, Marie‐Laure and Granum, Per Einar
Molecular Microbiology, ISSN 0950-382X, 10/2000, Volume 38, Issue 2, pp. 254 - 261
A cytotoxin (CytK) has been isolated from a Bacillus cereus strain that caused a severe food poisoning outbreak killing three people. A protein of 34 kDa was... 
HEMOLYSIN BL | GAMMA-HEMOLYSIN | COMPLEX | GENE | ALPHA-HEMOLYSIN | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | MICROBIOLOGY | STAPHYLOCOCCUS-AUREUS | THURINGIENSIS | IDENTIFICATION | Foodborne Diseases - microbiology | Humans | Cercopithecus aethiops | Molecular Sequence Data | Enterotoxins - isolation & purification | Bacterial Toxins - isolation & purification | DNA, Bacterial | Necrosis | Bacillus cereus - genetics | Disease Outbreaks | Base Sequence | Cytotoxins - metabolism | Bacterial Toxins - genetics | Enteritis | Vero Cells | Hemolysis | Amino Acid Sequence | Rabbits | France - epidemiology | Cytotoxins - isolation & purification | Sequence Homology, Amino Acid | Bacterial Toxins - metabolism | Enterotoxins - genetics | Animals | Enterotoxins - metabolism | Foodborne Diseases - epidemiology | Cytotoxins - genetics | g-haemolysin | a-Hemolysin | cytotoxins | PlcR protein | leucocidin | hemolysin II | a-haemolysin | Nhe protein | b-toxin | CytK protein | g-Hemolysin | HBL protein | cytotoxin CytK | Index Medicus
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10. Full Text Cancer cell injury by cytotoxins from cobra venom is mediated through lysosomal damage
by Feofanov, Alexei V and Sharonov, George V and Astapova, Maria V and Rodionov, Dmitriy I and Utkin, Yuriy N and Arseniev, Alexander S
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 390, Issue 1, pp. 11 - 18
Cytotoxins from cobra venom are known to manifest cytotoxicity in various cell types. It is widely accepted that the plasma membrane is a target of cytotoxins,... 
Cytotoxicity | Cobra venom | Cytotoxin | Confocal spectral imaging | Lysosome | PROTEIN-KINASE-C | CHLORIN P6 | cobra venom | POSSIBLE MECHANISMS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENZYME-INHIBITION | cytotoxin | TUMOR-CELLS | SPECTRAL IMAGING ANALYSIS | PHOTODYNAMIC PROPERTIES | CARDIOTOXIN | lysosome | LIVING K562 CELLS | cytotoxicity | confocal spectral imaging | Elapid Venoms - chemistry | Lysosomes - drug effects | Humans | Lung Neoplasms - metabolism | Cell Membrane - chemistry | Biological Transport, Active | Leukemia, Promyelocytic, Acute - metabolism | Adenocarcinoma - metabolism | Animals | Cytotoxins - pharmacology | Lysosomes - metabolism | Time Factors | Cell Death | Cytotoxins - chemistry | Cell Line, Tumor | Cytotoxins - metabolism | Protein Binding | Index Medicus | Rh-CT, tetramethylrhodamine-labelled cytotoxin | AO, Acridine Orange | CT, cytotoxin | Rh, tetramethylrhodamine | the suffixes No, Nk, Nh and Na denote cytotoxins from Naja oxiana, Naja kaouthia, Naja haje and Naja atra respectively | CSI, confocal spectral imaging | NTII, neurotoxin II from Naja oxiana
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11. Full Text Functional and Phylogenetic Characterization of Vaginolysin, the Human-Specific Cytolysin from Gardnerella vaginalis
by Shari E. Gelber and Jorge L. Aguilar and Kanako L. T. Lewis and Adam J. Ratner
Journal of Bacteriology, ISSN 0021-9193, 06/2008, Volume 190, Issue 11, pp. 3896 - 3903
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
Cricetulus | Species Specificity | Epithelial Cells - drug effects | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Cytotoxins - classification | Phylogeny | Gardnerella vaginalis - genetics | Gardnerella vaginalis - metabolism | Cloning, Molecular | Cytotoxins - metabolism | Bacterial Toxins - genetics | CHO Cells | Amino Acid Sequence | Cricetinae | Genome, Bacterial | Bacterial Toxins - classification | Bacterial Proteins - genetics | Bacterial Toxins - chemistry | Gene Expression Regulation, Bacterial - physiology | Bacterial Toxins - metabolism | Animals | Cytotoxins - chemistry | Bacterial Proteins - metabolism | Bacterial Proteins - classification | HeLa Cells | Cytotoxins - genetics | Bacterial toxins | Causes of | Anaerobic bacteria | Health aspects | Vaginosis | Human immunodeficiency virus--HIV | Bacteria | Amino acids | Toxins | Biochemistry | Kinases | Bacteriology | Index Medicus | Molecular Biology of Pathogens
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12. Full Text Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability
by Sussman, D and Westendorf, L and Meyer, D W and Leiske, C I and Anderson, M and Okeley, N M and Alley, S C and Lyon, R and Sanderson, R J and Carter, P J and Benjamin, D R
Protein Engineering, Design and Selection, ISSN 1741-0126, 02/2018, Volume 31, Issue 2, pp. 47 - 54
Abstract Antibody-drug conjugates (ADCs) are fulfilling the promise of targeted therapy with meaningful clinical success. An intense research effort is... 
antibody engineering | targeted therapy | Antibody-drug conjugate | ATTACHMENT | antibody-drug conjugate | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITE-SPECIFIC CONJUGATION | CANCER-THERAPY | Protein Engineering - methods | Single-Chain Antibodies - pharmacology | Humans | Rats | Cytotoxins - isolation & purification | Immunoconjugates - chemistry | Immunoconjugates - pharmacology | Animals | Cytotoxins - biosynthesis | Cytotoxins - pharmacology | Single-Chain Antibodies - isolation & purification | Mice, Nude | Cytotoxins - chemistry | Single-Chain Antibodies - biosynthesis | Female | Mice | Single-Chain Antibodies - chemistry | Immunoconjugates - isolation & purification | Index Medicus
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13. Full Text 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
by Hewings, David S and Wang, Minghua and Philpott, Martin and Fedorov, Oleg and Uttarkar, Sagar and Filippakopoulos, Panagis and Picaud, Sarah and Vuppusetty, Chaitanya and Marsden, Brian and Knapp, Stefan and Conway, Stuart J and Heightman, Tom D
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 19, pp. 6761 - 6770
Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind... 
IN-VITRO | CODE | CHEMISTRY, MEDICINAL | PROTEIN | GENE | STRUCTURAL BASIS | INTERACTS | CGRP RECEPTOR ANTAGONISTS | INHIBITORS | HISTONE ACETYLATION | FAMILY | Phenylethyl Alcohol - analogs & derivatives | Stereoisomerism | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Isoxazoles - chemical synthesis | CREB-Binding Protein - metabolism | Molecular Mimicry | Cytotoxins - pharmacology | Lysine - metabolism | Molecular Structure | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Cytotoxins - chemical synthesis | Models, Molecular | Nuclear Proteins - metabolism | Isoxazoles - chemistry | Isoxazoles - pharmacology | Transcription Factors - metabolism | Phenylethyl Alcohol - pharmacology | Cytotoxins - chemistry | Phenylethyl Alcohol - chemical synthesis | Protein Binding | Ligands | HeLa Cells | Histones - metabolism | Phenylethyl Alcohol - chemistry | Index Medicus
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14. Full Text Synthesis of hemoglobin conjugated polymeric micelle: A ZnPc carrier with oxygen self-compensating ability for photodynamic therapy
by Wang, Shasha and Yuan, Fang and Chen, Kui and Chen, Gaojian and Tu, Kehua and Wang, Hongjun and Wang, Li-Qun
Biomacromolecules, ISSN 1525-7797, 09/2015, Volume 16, Issue 9, pp. 2693 - 2700
Photodynamic therapy (PDT) is a promising singlet oxygen (O-1(2)) mediated clinical treatment for many tumors. As the source of O-1(2), oxygen plays an... 
ENCAPSULATED HEMOGLOBIN | POLYMER SCIENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZERS | CHEMISTRY, ORGANIC | CANCER | NANOPARTICLES | MICROENVIRONMENT | PHTHALOCYANINE | SINGLET OXYGEN | LIPOSOMES | PROBE | WATER | Oxygen - pharmacology | Cytotoxins - chemical synthesis | Humans | Polyethylene Glycols - chemistry | Zinc - chemistry | Photochemotherapy | Hemoglobins - chemistry | Cytotoxins - pharmacology | Micelles | Cytotoxins - chemistry | Oxygen - chemistry | Indoles - pharmacology | HeLa Cells | Hemoglobins - pharmacology | Indoles - chemistry | Polyethylene Glycols - pharmacology | Index Medicus
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15. Immunopharmacology and immunotoxicology
Immunopharmacology and immunotoxicology, ISSN 0892-3973, 1987
Periodicals | Immunopharmacology | Immunotoxicology
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