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Journal of Molecular Biology, ISSN 0022-2836, 04/2001, Volume 307, Issue 5, pp. 1235 - 1245
DNA double-strand breaks (DSB) represent a major disruption in the integrity of the genome. DSB can be generated when a replication fork encounters a DNA... 
replication fork | hypoxanthine-guanine phosphoribosyltransferase | homologous recombination | exchange mechanism | DNA double-strand break | Hypoxanthine-guanine phosphoribosyltransferase | Replication fork | Homologous recombination | Exchange mechanism | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVABLE COMPLEXES | DEPENDENT PROTEIN-KINASE | TOPOISOMERASE-I | NONHOMOLOGOUS RECOMBINATION | CHROMOSOME BREAKS | CHINESE-HAMSTER CELLS | ILLEGITIMATE RECOMBINATION | ATAXIA-TELANGIECTASIA | INTRAGENIC RECOMBINATION | SISTER-CHROMATID EXCHANGES | DNA Repair - genetics | Dose-Response Relationship, Drug | Cytotoxins - pharmacology | DNA-Activated Protein Kinase | Flow Cytometry | Gene Deletion | S Phase | DNA Damage - genetics | Recombination, Genetic - genetics | DNA-Binding Proteins | DNA Damage - drug effects | Cell Line | Cricetinae | DNA Repair - drug effects | Protein-Serine-Threonine Kinases - genetics | DNA - metabolism | Electrophoresis, Gel, Pulsed-Field | Sequence Homology, Nucleic Acid | DNA - genetics | DNA - chemistry | Animals | Hypoxanthine Phosphoribosyltransferase - genetics | DNA Replication - genetics | Models, Genetic | Camptothecin - pharmacology | Recombination, Genetic - drug effects | hprt gene | Sequence Homology; Nucleic Acid | Electrophoresis; Gel; Pulsed-Field | Camptothecin/pharmacology | DNA Damage/drug effects/genetics | Dose-Response Relationship; Drug | Recombination; Genetic/drug effects/genetics | DNA Replication/genetics | Protein-Serine-Threonine Kinases/genetics | Models; Genetic | DNA Repair/drug effects/genetics | DNA/chemistry/genetics/metabolism | Hypoxanthine Phosphoribosyltransferase/genetics | Cytotoxins/pharmacology
Journal Article
Cancer Medicine, ISSN 2045-7634, 03/2017, Volume 6, Issue 3, pp. 708 - 720
Gene–environment interactions may increase gastric cancer (GC) risk. Seven susceptibility loci identified by genome‐wide association studies (GWASs) suggest... 
Gene–environment interactions | genetic variant | Helicobacter pylori | precancerous lesions | GWAS, gastric cancer | GWAS | gastric cancer | PSCA | VARIANTS | VACUOLATING CYTOTOXIN | ANTIGENS | POLYMORPHISM | Gene-environment interactions | GENETIC-VARIATION | ONCOLOGY | HELICOBACTER-PYLORI INFECTION | SQUAMOUS-CELL CARCINOMA | EXPRESSION | GENOME-WIDE ASSOCIATION | Smoking - adverse effects | Humans | Asian Continental Ancestry Group - genetics | Helicobacter Infections - complications | Male | Membrane Transport Proteins - genetics | China | Female | Neoplasm Proteins - genetics | Stomach Neoplasms - etiology | Stomach Neoplasms - genetics | Antigens, Neoplasm - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Risk Factors | Logistic Models | Smoking - genetics | Transcription Factors - genetics | Helicobacter Infections - genetics | Alcohol Drinking - adverse effects | Nerve Tissue Proteins - genetics | Alcohol Drinking - genetics | AMP-Activated Protein Kinases - genetics | GPI-Linked Proteins - genetics | Mucin-1 - genetics | Dysplasia | Oncology, Experimental | Genomics | Helicobacter infections | Disease susceptibility | Research | Health aspects | Stomach cancer | Risk factors | Genetic polymorphisms | Cancer | Drinking behavior | Alcohol | Infections | Genomes | Single-nucleotide polymorphism | Environmental factors | Population genetics | Carcinogenesis | Studies | Metaplasia | Genotyping | Intestine | Biopsy | Population | Genetic testing | Genetic factors | Endoscopy | Gastric cancer | Deoxyribonucleic acid--DNA | Smoking | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 01/2008, Volume 68, Issue 2, pp. 379 - 387
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 04/2017, Volume 241, Issue 5, pp. 614 - 625
Journal Article
Current Genetics, ISSN 0172-8083, 12/2017, Volume 63, Issue 6, pp. 1081 - 1091
Dph3 is involved in diphthamide modification of the eukaryotic translation elongation factor eEF2 and in Elongator-mediated modifications of tRNAs, where a... 
Biochemistry, general | Microbiology | tRNA modifications | DNA damage response | Elongator | Genome stability | Sordarin | Cell Biology | Life Sciences | Translation elongation factor eEF2 | Transcriptional interference | Microbial Genetics and Genomics | Proteomics | Plant Sciences | COMPLEX | DIPHTHAMIDE | TRANSFER-RNA MODIFICATION | MISMATCH REPAIR | IDENTIFICATION | TRANSLATION | SACCHAROMYCES-CEREVISIAE | DIPHTHERIA-TOXIN | GENETICS & HEREDITY | FUNGAL PROTEIN-SYNTHESIS | ELONGATION-FACTOR 2 | Gene Expression Regulation, Fungal | Histidine - analogs & derivatives | Hydroxyurea - pharmacology | Indenes - pharmacology | Schizosaccharomyces - drug effects | Schizosaccharomyces pombe Proteins - genetics | Saccharomyces cerevisiae - genetics | Codon, Initiator | Genetic Loci | Genetic Markers | Histidine - metabolism | MutS Homolog 3 Protein - genetics | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Schizosaccharomyces - metabolism | Peptide Elongation Factor 2 - genetics | Cytotoxins - pharmacology | Genetic Engineering | Schizosaccharomyces pombe Proteins - metabolism | Mutation | Methyl Methanesulfonate - pharmacology | MutS Homolog 3 Protein - deficiency | Peptide Elongation Factor 2 - metabolism | Medical colleges | Oncology, Experimental | Genes | Genomics | Protein biosynthesis | Research | Genetic transcription | DNA repair | Proteins | Codon | Genetic research | Cancer | Transfer RNA | Drugs | Yeast | Fungicides | DNA damage | Ribosomes | Cytotoxicity | Hydroxyurea | Methyl methanesulfonate | Saccharomyces | Mating | Gene disruption | Elongation | Deoxyribonucleic acid--DNA | Cassettes | Translation | Cell survival | Loci | Switching | Strain | DNA biosynthesis | Sensitivity | Protein synthesis | Translation elongation | Codons | Cytotoxic agents | Saccharomyces cerevisiae | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 20021 - 20026
Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when treating infiltrative brain... 
Cytotoxins | Neurotoxicity | Receptors | Glioma | Neurons | Toxicity | Medical treatment | Transgenes | Heterologous transplantation | Tumors | Adenoviral vectors | Immunotoxins | GBM12 tumors | TetON system | Targeted glioma therapeutics | CELLS | adenoviral vectors | GLIOBLASTOMA-MULTIFORME | MULTIDISCIPLINARY SCIENCES | RESTRICTIVE RECEPTOR | targeted glioma therapeutics | TEMOZOLOMIDE | RECURRENT MALIGNANT GLIOMA | INTERLEUKIN-13 RECEPTOR | immunotoxins | PSEUDOMONAS EXOTOXIN | EXPRESSION | CONVECTION-ENHANCED DELIVERY | BRAIN | Genetic Therapy | Interleukin-13 - therapeutic use | Humans | Brain Neoplasms - pathology | Interleukin-13 - genetics | Glioma - pathology | Adenoviridae - genetics | Cytotoxins - therapeutic use | Gene Transfer Techniques | Transgenes - genetics | Immunocompetence - immunology | Neurotoxins - toxicity | Treatment Outcome | Brain Neoplasms - drug therapy | Mutation - genetics | Genetic Vectors - genetics | Xenograft Model Antitumor Assays | Exotoxins - therapeutic use | Animals | Mice, Nude | Exotoxins - genetics | Cell Line, Tumor | Mice | Cytotoxins - genetics | Glioma - drug therapy | Pseudomonas - metabolism | Care and treatment | Gliomas | Brain tumors | Genetic aspects | Research | Antibody-toxin conjugates | Properties | Gene therapy | Health aspects | Cancer | glioblastoma multiforme | Animal models | Interleukin 13 receptors | Tumor cells | Clinical trials | Cytotoxicity | Interleukin 13 | Drug development | Survival | Interleukin 4 | Antitumor agents | Exotoxins | Interleukin 1 | Xenografts | Interleukin 4 receptors | Expression vectors | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 30, pp. 24929 - 24940
Journal Article