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CELL, ISSN 0092-8674, 10/2003, Volume 115, Issue 1, pp. 25 - 35
The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells,... 
OUTER-MEMBRANE VESICLES | HOST-CELLS | IN-VITRO | HEAT-LABILE ENTEROTOXIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI K-12 | GENERAL SECRETORY PATHWAY | SHEA | PROTEIN SECRETION | HEMOLYSIN-E | CELL BIOLOGY | Oxidation-Reduction | Protein Disulfide-Isomerases - metabolism | Humans | Bacterial Proteins - chemistry | Hemolysin Proteins - chemistry | Bacterial Toxins - chemistry | Cell Membrane - chemistry | Bacterial Toxins - metabolism | Animals | Transport Vesicles - metabolism | Cytotoxins - chemistry | Escherichia coli - metabolism | Cytotoxins - metabolism | Bacterial Proteins - metabolism | Polymers - chemistry | Cell Membrane - metabolism | Membrane Proteins - metabolism | HeLa Cells | Escherichia coli - ultrastructure | Hemolysin Proteins - metabolism | Polymers - metabolism | Salmonella - metabolism | Transport Vesicles - ultrastructure | Bacterial toxins | Physiological aspects | Gram-negative bacteria | Secretion | Biological transport | Bacterial Toxins/chemistry/metabolism | Cytotoxins/chemistry/metabolism | Salmonella/metabolism | Cell Membrane/chemistry/metabolism | Escherichia coli/metabolism/ultrastructure | Bacterial Proteins/chemistry/metabolism | Transport Vesicles/metabolism/ultrastructure | Membrane Proteins/metabolism | Hemolysin Proteins/chemistry/metabolism | Polymers/chemistry/metabolism | Hela Cells | Protein Disulfide-Isomerase/metabolism
Journal Article
BMC Genomics, ISSN 1471-2164, 2014, Volume 15, Issue 1, pp. 1165 - 1165
Journal Article
Current Protein and Peptide Science, ISSN 1389-2037, 08/2017, Volume 18, Issue 8, pp. 795 - 808
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact... 
Dietary protein | Metabolites | Amino acid balance | Intestinal microbiota | Gut barrier | Digestibility | LIPID-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER FUNCTION | HYDROGEN-SULFIDE | CELL-GROWTH | WEANED PIGS | BUTYRATE-PRODUCING BACTERIA | metabolites | GROWTH-PERFORMANCE | POSTWEANING DIARRHEA | intestinal microbiota | amino acid balance | SOYBEAN-MEAL | CHAIN FATTY-ACIDS | gut barrier | digestibility | Dietary Proteins - administration & dosage | Proteobacteria - metabolism | Humans | Gastrointestinal Microbiome - physiology | Dietary Carbohydrates - metabolism | Fusobacteria - metabolism | Dietary Proteins - metabolism | Proteolysis | Actinobacteria - metabolism | Firmicutes - metabolism | Verrucomicrobia - growth & development | Dietary Carbohydrates - administration & dosage | Firmicutes - growth & development | Fatty Acids, Volatile - biosynthesis | Ammonia - metabolism | Gastrointestinal Tract - microbiology | Gastrointestinal Tract - drug effects | Fermentation | Amines - metabolism | Fusobacteria - growth & development | Verrucomicrobia - metabolism | Gastrointestinal Microbiome - drug effects | Bacteroidetes - metabolism | Actinobacteria - growth & development | Bacteroidetes - growth & development | Proteobacteria - growth & development | Sulfide | Inflammatory bowel diseases | Amines | Protein turnover | Proteins | Low carbohydrate diet | Carcinogens | Microorganisms | Microbiota | Colon cancer | Intestine | Colon | Digestive tract | Low protein diet | Immune system | Carbohydrates | Protein metabolism | Nutrient deficiency | Secretion | Digestive system | Health | Health risks | Dietary supplements | Amino acid composition | Gastrointestinal tract | Gene expression | Metabolism | Fatty acids | Gases | Cytotoxins | Ammonia | Signaling | Diet | Cancer
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2016, Volume 117, Issue 4, pp. 917 - 926
ABSTRACT Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic... 
INSULIN | GLYCOGEN SYNTHASE KINASE‐3 (GSK‐3) | TYROSINE HYDROXYLASE (TH) | Bcl‐2 | PROTEIN KINASE B (Akt) | SH‐SY5Y | Bcl-2 | SH-SY5Y | GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | NERVOUS-SYSTEM | OXIDATIVE STRESS | TYROSINE-HYDROXYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT/BCL-2 SIGNALING PATHWAYS | DEATH | DOPAMINERGIC-NEURONS | CELL BIOLOGY | INHIBITION | GENE-EXPRESSION | NITRIC-OXIDE | BRAIN | Tyrosine 3-Monooxygenase - metabolism | Reactive Oxygen Species - metabolism | Calcium - metabolism | Dopaminergic Neurons - pathology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Cytotoxins - toxicity | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neuroprotective Agents - pharmacology | Dopaminergic Neurons - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Dopaminergic Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cytotoxins - antagonists & inhibitors | bcl-2-Associated X Protein - genetics | Tretinoin - pharmacology | Insulin - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | 1-Methyl-4-phenylpyridinium - antagonists & inhibitors | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Tyrosine 3-Monooxygenase - genetics | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Nitric Oxide Synthase Type II - genetics | Cell Differentiation - drug effects | 1-Methyl-4-phenylpyridinium - toxicity | Cell Line, Tumor | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Insulin | Analysis | Nitric oxide | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2003, Volume 116, Issue 4, pp. 725 - 742
The apical-most epithelial intercellular junction, referred to as the tight junction (TJ), regulates paracellular solute flux in diverse physiological and... 
Tight junction | F-actin | Rho GTPases | Epithelium | Paracellular permeability | TOXIN-INDUCED ACTIVATION | GTP-BINDING PROTEIN | CANINE KIDNEY-CELLS | paracellular permeability | ESCHERICHIA-COLI | PHAGOCYTIC BEHAVIOR | CELL BIOLOGY | ACTIN STRESS FIBERS | BACTERIAL TOXINS | epithelium | CYTOTOXIC NECROTIZING FACTOR-1 | FOCAL ADHESION KINASE | tight junction | RAC1 SMALL GTPASES | Immunohistochemistry | Cadherins - metabolism | Cell Adhesion Molecules | Humans | rac GTP-Binding Proteins - metabolism | Actins - drug effects | cdc42 GTP-Binding Protein - metabolism | Caveolins - metabolism | Carrier Proteins - drug effects | Endosomes - metabolism | Caveolin 1 | Cytotoxins - pharmacology | Endosomes - drug effects | Endosomes - ultrastructure | Tight Junctions - drug effects | Tight Junctions - metabolism | Epithelium - drug effects | Epithelium - metabolism | Tight Junctions - ultrastructure | Cell Membrane Permeability - physiology | Cell Membrane Permeability - drug effects | rho GTP-Binding Proteins - metabolism | Adherens Junctions - drug effects | Membrane Proteins - drug effects | Paxillin | cdc42 GTP-Binding Protein - drug effects | Phosphoproteins - drug effects | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Actins - metabolism | Receptors, Cell Surface | Epithelium - ultrastructure | Phosphoproteins - metabolism | Adherens Junctions - metabolism | Occludin | Cytoskeletal Proteins - metabolism | Cytoskeletal Proteins - drug effects | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Tumor Cells, Cultured | Caveolins - drug effects | Epithelial Cells - ultrastructure | Cadherins - drug effects | Microscopy, Electron | Carrier Proteins - metabolism | Escherichia coli Proteins | Zonula Occludens-1 Protein | Microfilament Proteins - drug effects | Bacterial Toxins - pharmacology | Adherens Junctions - ultrastructure | rac GTP-Binding Proteins - drug effects
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2004, Volume 279, Issue 29, pp. 30622 - 30633
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 3/2011, Volume 383, Issue 3, pp. 253 - 262
Toxin A and toxin B from Clostridium difficile are the causative agents of the antibiotic-associated pseudomembranous colitis. They are of an A/B structure... 
Neurosciences | Endocytosis | Biomedicine | Rho GTPases | Bacterial toxin | Clostridium difficile | Autoproteolysis | Pharmacology/Toxicology | CELLS | APOPTOSIS | DOMAIN | DEPENDS | INOSITOL HEXAKISPHOSPHATE | DISEASE | PHARMACOLOGY & PHARMACY | GLUCOSYLATION | RHO-GTPASES | PROTEINS | EXPRESSION | Phytic Acid - chemistry | NIH 3T3 Cells | Apoptosis - drug effects | Humans | Bacterial Proteins - chemistry | Caspase 3 - metabolism | Caspase 8 - metabolism | Cysteine Proteases - metabolism | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Dose-Response Relationship, Drug | Glucosyltransferases - metabolism | Cytotoxins - pharmacology | Cytotoxins - metabolism | Cell Membrane - metabolism | Dithiothreitol - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Glycosylation | Bacterial Toxins - chemistry | Cell Shape - drug effects | HT29 Cells | Bacterial Proteins - pharmacology | Bacterial Toxins - metabolism | Animals | Amino Acid Substitution - physiology | Bacterial Toxins - pharmacology | Cytotoxins - chemistry | Enterotoxins - metabolism | Bacterial Proteins - metabolism | Cytosol - metabolism | Mice | Enterotoxins - chemistry | Enterotoxins - pharmacology | rac1 GTP-Binding Protein - metabolism | Protein Structure, Tertiary - physiology | Inositol | G proteins
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82322
Vacuolating cytotoxin A (VacA) is one of the important virulence factors produced by H. pylori. VacA induces apoptotic cell death, which is potentiated by... 
UNFOLDED PROTEIN RESPONSE | FATTY LIVER-DISEASE | VACUOLATING CYTOTOXIN | ER STRESS | MULTIDISCIPLINARY SCIENCES | GASTRIC EPITHELIAL-CELLS | DEATH | CYTOCHROME-C RELEASE | UP-REGULATION | TOXIN VACA | MOLECULAR-MECHANISMS | Gastric Mucosa - microbiology | Apoptosis - drug effects | eIF-2 Kinase - metabolism | Humans | Gastric Mucosa - pathology | Helicobacter pylori - drug effects | Gastric Mucosa - metabolism | RNA, Messenger - metabolism | Vacuoles - drug effects | Heat-Shock Proteins - genetics | Ammonium Chloride - pharmacology | Bcl-2-Like Protein 11 | Eukaryotic Initiation Factor-2 - metabolism | Membrane Proteins - metabolism | Phosphorylation - drug effects | Biomarkers - metabolism | Proto-Oncogene Proteins - metabolism | Endoplasmic Reticulum Stress - drug effects | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Helicobacter pylori - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Vacuoles - metabolism | Bacterial Proteins - metabolism | Transcription Factor CHOP - metabolism | Proteins | Ammonium compounds | Ammonia | Helicobacter pylori | Ammonium paratungstate | Helicobacter infections | Apoptosis | Cytochrome | Ammonium | Phosphorylation | Bax protein | Transcription | Toxicity | Epithelial cells | Mucosa | Virulence | Gastric mucosa | Homology | Infections | Activation | CCAAT/enhancer-binding protein | Kinases | Stomach cancer | Ammonium chloride | Mitochondria | Cell activation | Virulence factors | Chlorides | Hepatology | Gastroenterology | Stresses | Incubation | Mortality | siRNA | Permeability | Gene expression | Stress | Bacteriology | Signaling | Cell death | Endoplasmic reticulum | BIM protein
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7597, pp. 64 - 68
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells... 
PATHOGENICITY MECHANISMS | BETA-MANNOSYLATION | PROTEIN-KINASE HOMOLOG | OROPHARYNGEAL CANDIDIASIS | EPITHELIAL-CELLS | FILAMENTOUS GROWTH | MULTIDISCIPLINARY SCIENCES | HYPHAL DEVELOPMENT | ALBICANS ENCODES | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | Virulence - drug effects | Virulence Factors - genetics | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Fungal Proteins - toxicity | Candida albicans - metabolism | Cytotoxins - secretion | Candidiasis - microbiology | Cytotoxins - toxicity | Host-Pathogen Interactions - immunology | Cytotoxins - metabolism | Mycotoxins - metabolism | Mycotoxins - genetics | Candidiasis - pathology | Virulence Factors - toxicity | Candida albicans - pathogenicity | Mycotoxins - secretion | Epithelial Cells - pathology | Fungal Proteins - genetics | Candida albicans - immunology | Mycotoxins - toxicity | Candidiasis - metabolism | Mucous Membrane - pathology | Signal Transduction - drug effects | Cell Membrane Permeability - drug effects | Epithelial Cells - immunology | Fungal Proteins - secretion | Virulence Factors - metabolism | Cytotoxins - genetics | Mucous Membrane - microbiology | Fungal Proteins - metabolism | Candida albicans | Fungi | Physiological aspects | Mucous membrane | Proteins | Yeast | Peptides | Cytokines | Pathogenesis | Toxins | Fungal infections
Journal Article