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1. Immunopharmacology and immunotoxicology
Immunopharmacology and immunotoxicology, ISSN 0892-3973, 1987
Periodicals | Immunopharmacology | Immunotoxicology
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2. Full Text Non platinum metal complexes as anti-cancer drugs
by Ott, Ingo and Gust, Ronald
Archiv der Pharmazie, ISSN 0365-6233, 03/2007, Volume 340, Issue 3, pp. 117 - 126
The development of metal complexes with platinum central atoms such as cisplatin or carboplatin had an enormous impact on current cancer chemotherapy. However,... 
Gold | Ruthenium | Cobalt | Metal complexes | Anti-tumour | metal complexes | TITANOCENE DICHLORIDE | CHEMISTRY, MEDICINAL | anti-tumour | cobalt | ANTITUMOR-ACTIVITY | HYPOXIA-SELECTIVE CYTOTOXINS | CHEMISTRY, MULTIDISCIPLINARY | TRIETHYLPHOSPHINE GOLD(I) COMPLEXES | gold | ruthenium | PHASE-II TRIAL | IN-VITRO | COBALT CARBONYL-COMPLEXES | TUMOR-CELL TOXICITY | CANCER-TREATMENT | PHARMACOLOGY & PHARMACY | THIOREDOXIN REDUCTASE | Organometallic Compounds - toxicity | Titanium - pharmacology | Humans | Ferric Compounds - pharmacology | Treatment Outcome | Antineoplastic Agents - therapeutic use | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - toxicity | Neoplasms - drug therapy | Gallium - pharmacology | Animals | Cobalt - pharmacology | Organogold Compounds - pharmacology | Ferrous Compounds - pharmacology | Organometallic Compounds - therapeutic use | Antineoplastic Agents - pharmacology | Molecular Structure | Organometallic Compounds - pharmacology | Ruthenium Compounds - pharmacology
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3. Full Text Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation
by Parks, Alexandre and Marceau, François
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Cation trapping in acidic cell compartments determines an antiproliferative effect that has a potential interest in oncology, as shown by clinical data and... 
Lysosomotropic drugs | Quinacrine | Antiproliferative effect | Cation trapping | Autophagic flux | CELLS | CHLOROQUINE | VACUOLAR ATPASE | IN-VITRO | INDUCED PHOSPHOLIPIDOSIS | INHIBITION | DNA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | CAPTURE | Human Umbilical Vein Endothelial Cells | Lidocaine - pharmacology | Lovastatin - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Cells, Cultured | Lysosomes | Poly (ADP-Ribose) Polymerase-1 - metabolism | Cholesterol - metabolism | beta-Cyclodextrins - pharmacology | Autophagy - drug effects | Chloroquine - pharmacology | Quinacrine - pharmacology | Cytotoxins - pharmacology | Procainamide - pharmacology | Cell Line, Tumor | Hydroxychloroquine - pharmacology | Cell Proliferation - drug effects | Cytostatic Agents - pharmacology | Anticholesteremic Agents - pharmacology | Amiodarone - pharmacology | Drugs | Cyclodextrins | Hydroxychloroquine | Tumor proteins | Analysis | Cholesterol | Lymphomas | Index Medicus | APOPTOSIS | OLIGOSACCHARIDES | CHOLESTEROL | ANTIMITOTIC DRUGS | COMPARTMENTS | TOXICITY | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | ABUNDANCE | LYMPHOMAS | BIOLOGICAL MARKERS | ABLATION | CELL CYCLE
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4. Full Text Marine pharmacology in 2005–2006: Antitumour and cytotoxic compounds
by Mayer, Alejandro M.S and Gustafson, Kirk R
European Journal of Cancer, ISSN 0959-8049, 2008, Volume 44, Issue 16, pp. 2357 - 2387
Abstract During 2005 and 2006, marine pharmacology research directed towards the discovery and development of novel antitumour agents was reported in 171... 
Hematology, Oncology and Palliative Medicine | Drugs | Screening | Chemotherapy | Marine | Antineoplastic | Antitumour | Agents | Pharmacology | Review | Cancer | ADVANCED SOLID TUMORS | SOFT-TISSUE SARCOMAS | ADVANCED BREAST-CANCER | CUCUMBER PENTACTA-QUADRANGULARIS | MULTICENTER PHASE-II | ENDOPLASMIC-RETICULUM STRESS | SULFATED TRITERPENE GLYCOSIDES | ONCOLOGY | NEW-GUINEA COLLECTION | CYANOBACTERIUM LYNGBYA-MAJUSCULA | SPONGE THEONELLA-SWINHOEI | Humans | Biological Products - pharmacology | Clinical Trials as Topic | Antineoplastic Agents - chemistry | Cytotoxins - isolation & purification | Biological Products - isolation & purification | Neoplasms - drug therapy | Marine Biology | Biological Products - chemistry | Cytotoxins - pharmacology | Antineoplastic Agents - isolation & purification | Cytotoxins - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Peptides | Oncology, Experimental | Analysis | Research | Terpenes | Tumors | Index Medicus
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5. Full Text Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
by Özçelik, Berrin and Kartal, Murat and Orhan, Ilkay
Pharmaceutical Biology, ISSN 1388-0209, 4/2011, Volume 49, Issue 4, pp. 396 - 402
Objective: Some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine... 
Alkaloids | parainfluenza | phenolic acids | antimicrobial activity | antiviral activity | flavonoids | herpes simplex | ANTIBACTERIAL | PLANT SCIENCES | IN-VITRO | HEPATITIS | ISOQUINOLINE | HERPES-SIMPLEX VIRUSES | PHARMACOLOGY & PHARMACY | SILYMARIN | ANTIFUNGAL | MEDICAL LABORATORY TECHNOLOGY | EXTRACTS | TYPE-1 | MEDICINAL-PLANTS | Antiviral Agents - toxicity | Bacteria - drug effects | Cercopithecus aethiops | Biological Products - pharmacology | Cytotoxins - toxicity | Hydroxybenzoates - pharmacology | Cytotoxins - pharmacology | Cattle | Biological Products - analysis | Flavonoids - pharmacology | Anti-Bacterial Agents - toxicity | Antioxidants - analysis | Parainfluenza Virus 3, Human - drug effects | Cell Line | Alkaloids - toxicity | Antiviral Agents - pharmacology | Alkaloids - pharmacology | Fungi - drug effects | Antioxidants - pharmacology | Herpesvirus 1, Human - drug effects | Antioxidants - toxicity | Flavonoids - toxicity | Animals | Anti-Bacterial Agents - pharmacology | Biological Products - toxicity | Hydroxybenzoates - toxicity | Index Medicus
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6. Full Text Cu2-xSe@mSiO2-PEG core-shell nanoparticles: A low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density
by Liu, Xijian and Wang, Qian and Li, Chun and Zou, Rujia and Li, Bo and Song, Guosheng and Xu, Kaibing and Zheng, Yun and Hu, Junqing
Nanoscale, ISSN 2040-3364, 04/2014, Volume 6, Issue 8, pp. 4361 - 4370
A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cuâ‚‚-xSe@mSiOâ‚‚-PEG core-shell... 
Selenium - chemistry | Silicon Dioxide - pharmacology | Antibiotics, Antineoplastic - pharmacology | Nanoparticles - chemistry | Selenium - pharmacology | Humans | Silicon Dioxide - chemistry | Copper - pharmacology | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Drug Carriers - chemistry | Drug Carriers - pharmacology | Neoplasms - therapy | Phototherapy - methods | Copper - chemistry | Cytotoxins - pharmacology | Antibiotics, Antineoplastic - chemistry | Infrared Rays | Cytotoxins - chemistry | HeLa Cells | Neoplasms - pathology | Doxorubicin - pharmacology | Polyethylene Glycols - pharmacology
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7. Full Text Sensitive Detection of the Natural Killer Cell-Mediated Cytotoxicity of Anti-CD20 Antibodies and Its Impairment by B-Cell Receptor Pathway Inhibitors
by Hassenrück, Floyd and Hassenrück, Floyd and Knödgen, Eva and Knödgen, Eva and Göckeritz, Elisa and Göckeritz, Elisa and Midda, Safi Hasan and Midda, Safi Hasan and Vondey, Verena and Vondey, Verena and Neumann, Lars and Neumann, Lars and Herter, Sylvia and Klein, Christian and Hallek, Michael and Hallek, Michael and Krause, Günter and Krause, Günter
BioMed research international, ISSN 2314-6133, 2018, Volume 2018, pp. 1023490 - 9
The antibody-dependent cell-mediated cytotoxicity (ADCC) of the anti-CD20 monoclonal antibodies (mAbs) rituximab and obinutuzumab against the cell line Raji... 
PRECLINICAL ACTIVITY | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | EFFICACY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RITUXIMAB | IBRUTINIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | THERAPEUTIC ANTIBODIES | KINASE INHIBITORS | MONOCLONAL-ANTIBODIES | GA101 | Leukocytes, Mononuclear - metabolism | Leukocytes, Mononuclear - drug effects | Purines - pharmacology | Antibodies, Monoclonal - pharmacology | Humans | Antigens, CD20 - metabolism | Pyrimidines - pharmacology | Receptors, Antigen, B-Cell - metabolism | Rituximab - pharmacology | B-Lymphocytes - drug effects | Cytotoxins - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Cell Line, Tumor | Benzamides - pharmacology | Killer Cells, Natural - drug effects | Protein Kinase Inhibitors - pharmacology | Antibody-Dependent Cell Cytotoxicity - drug effects | Pyrazines - pharmacology | Quinazolinones - pharmacology | Pyrazoles - pharmacology | Toxicity | Leukemia | Impairment | Effector cells | Cytotoxicity | Leukocytes (mononuclear) | B-cell receptor | Kinases | Peripheral blood mononuclear cells | Natural killer cells | Calcein | Genetic modification | Recombinant | Antibody-dependent cell-mediated cytotoxicity | Immunoglobulins | Chronic lymphatic leukemia | Comorbidity | Interference | Rituximab | Lactate dehydrogenase | T cell receptors | Bruton's tyrosine kinase | L-Lactate dehydrogenase | CD16 antigen | Inhibitors | Lymphocytes B | Cell lines | Monoclonal antibodies | CD20 antigen | Lymphomas | Lactic acid
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8. Full Text Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
by Leipold, Douglas D and Weir, Sylvia and Junutula, Jagath R and Scheller, Richard H and Vandlen, Richard and Flagella, Kelly and Simpson, Michelle and Meng, Y Gloria and Bhakta, Sunil and Duenas, Eileen and Kim, Amy and Spencer, Susan D and Gorrell, Jeffrey and Katta, Viswanatham and Mallet, William and Dennis, Mark S and Tsai, Siao Ping and Raab, Helga and Ross, Sarajane and Lu, Yanmei and Ng, Carl and Yang, Jihong and Venook, Rayna and Lee Wong, Wai and Lowman, Henry B and Clark, Suzanna and McDorman, Kevin and Sliwkowski, Mark X and Polakis, Paul and Chen, Yvonne and Lee, Chien C
Nature Biotechnology, ISSN 1087-0156, 08/2008, Volume 26, Issue 8, pp. 925 - 932
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug... 
AURISTATIN-E CONJUGATE | IN-VITRO | MEMBRANE ANTIGEN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MONOCLONAL-ANTIBODY | DISULFIDE BOND | ANTITUMOR-ACTIVITY | CYSTEINE RESIDUES | ARMING ANTIBODIES | CANCER-THERAPY | IMMUNOCONJUGATE | Antibody Specificity | CA-125 Antigen - immunology | Chemistry, Pharmaceutical - methods | Sulfhydryl Compounds - pharmacology | Humans | Macaca fascicularis | Cysteine - genetics | Antibodies, Neoplasm - pharmacology | Cytotoxins - pharmacology | Female | Antineoplastic Agents - pharmacology | Binding Sites | Ovarian Neoplasms - drug therapy | Mutagenesis, Site-Directed | Antibodies, Monoclonal - pharmacology | Rats | Membrane Proteins - immunology | Rats, Sprague-Dawley | Antibodies, Monoclonal - genetics | Animals | Cell Line, Tumor | Immunotoxins - pharmacokinetics | Antibodies, Neoplasm - genetics | Mice | Oligopeptides - pharmacology | Ovarian Neoplasms - immunology | Research | Antibody-drug conjugates | Biotechnology | Toxicology | Biomedical research | Tumors | Ovarian cancer | Index Medicus
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9. Full Text A cytotoxic and cytostatic gold(iii) corrole
by Teo, Ruijie D and Gray, Harry B and Lim, Punnajit and Termini, John and Domeshek, Elena and Gross, Zeev
Chemical Communications, ISSN 1359-7345, 10/2014, Volume 5, Issue 89, pp. 13789 - 13792
We have synthesized and characterized a water-soluble gold( iii ) corrole ( 1-Au ) that is highly toxic to cisplatin-resistant cancer cells. Relative to its... 
REACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | COMPLEXES | GROWTH | Gold - chemistry | Cell Survival - drug effects | Cytostatic Agents - chemistry | Gallium - chemistry | Humans | Porphyrins - chemistry | Gold - pharmacology | Porphyrins - pharmacology | Antineoplastic Agents - chemistry | Gallium - pharmacology | Cytotoxins - pharmacology | Organogold Compounds - pharmacology | Cytotoxins - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cytostatic Agents - pharmacology | Serum Albumin - chemistry | Organogold Compounds - chemistry | Serum Albumin - metabolism | Index Medicus | Synthesis | Analogue | Toxicity | Affinity | Ligands | Serum albumin | Cancer
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10. Full Text Screening of Alternative Drugs to the Tumor Suppressor miR-375 in Esophageal Squamous Cell Carcinoma Using the Connectivity Map
by Isozaki, Yuka and Hoshino, Isamu and Akutsu, Yasunori and Hanari, Naoyuki and Mori, Mikito and Nishimori, Takanori and Murakami, Kentaro and Akanuma, Naoki and Toyozumi, Takeshi and Takahashi, Masahiko and Suito, Hiroshi and Takeshita, Nobuyoshi and Maruyama, Tetsuro and Suzuki, Akane and Nakayama, Toshinori and Matsubara, Hisahiro
Oncology, ISSN 0030-2414, 11/2014, Volume 87, Issue 6, pp. 351 - 363
Objective: The aim of this study was to identify alternative compounds to the tumor suppressor miR-375 using the connectivity map (CMAP) and to validate the... 
Clinical Translational Research | Pathway analysis | Catechin | miR-375 | Rosiglitazone | Esophageal squamous cell carcinoma | Metformin | Antitumor effect | Connectivity map | APOPTOSIS | HISTONE DEACETYLASE INHIBITOR | PREVENTION | MICRORNAS | CANCER | FK228 | ONCOLOGY | EXPRESSION | Apoptosis - drug effects | Humans | Transcriptome | MicroRNAs - metabolism | Cell Line, Tumor - drug effects | Cytotoxins - pharmacology | Transfection | Tumor Suppressor Proteins - genetics | Chenodeoxycholic Acid - pharmacology | Proline - pharmacology | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Thiazolidinediones - pharmacology | Real-Time Polymerase Chain Reaction | In Situ Nick-End Labeling | Proline - analogs & derivatives | Nizatidine - pharmacology | Metformin - pharmacology | Benzocaine - pharmacology | DNA Primers | Organophosphates - pharmacology | Carcinoma, Squamous Cell - drug therapy | MicroRNAs - drug effects | Betazole - pharmacology | Protein Array Analysis | Catechin - analogs & derivatives | Tumor Suppressor Proteins - drug effects | Esophageal Neoplasms - drug therapy
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11. Full Text Apratoxin H and apratoxin A sulfoxide from the red sea cyanobacterium Moorea producens
by Thornburg, Christopher C and Cowley, Elise S and Sikorska, Justyna and Shaala, Lamiaa A and Ishmael, Jane E and Youssef, Diaa T. A and McPhail, Kerry L
Journal of Natural Products, ISSN 0163-3864, 09/2013, Volume 76, Issue 9, pp. 1781 - 1788
Cultivation of the marine cyanobacterium Moorea producens, collected from the Nabq Mangroves in the Gulf of Aqaba (Red Sea), led to the isolation of new... 
COLLECTION | CHEMISTRY, MEDICINAL | LYNGBYA-MAJUSCULA | HEXAPEPTIDES | MODEL | ANTITUMOR-ACTIVITY | PLANT SCIENCES | POTENT | SPONGE | CYCLODEPSIPEPTIDE | PHARMACOLOGY & PHARMACY | CYCLIC DEPSIPEPTIDES | MARINE CYANOBACTERIA | Lyngbya Toxins - chemistry | Safrole - analogs & derivatives | Cyanobacteria - chemistry | Humans | Depsipeptides - pharmacology | Lactones - pharmacology | Marine Biology | Cytotoxins - pharmacology | Thiazoles - isolation & purification | Safrole - pharmacology | Inhibitory Concentration 50 | Safrole - chemistry | Molecular Structure | Safrole - isolation & purification | Depsipeptides - chemistry | Lactones - chemistry | Indian Ocean | Lactones - isolation & purification | Oxidation-Reduction | Depsipeptides - isolation & purification | Lyngbya Toxins - pharmacology | Cytotoxins - isolation & purification | Lyngbya Toxins - isolation & purification | Cytotoxins - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Drug Screening Assays, Antitumor | Pipecolic Acids - chemistry
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12. Full Text 3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins
by Karki, Subhas S and Das, Umashankar and Umemura, Naoki and Sakagami, Hiroshi and Iwamoto, Shoko and Kawase, Masami and Balzarini, Jan and De Clercq, Erik and Dimmock, Stephen G and Dimmock, Jonathan R
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 2, pp. 763 - 769
Novel 4-piperidone derivatives 2a-f are disclosed as potent cytotoxins. Many of these compounds are More potent than the reference drug melphalan The compounds... 
CELLS | CHEMISTRY, MEDICINAL | ANTICANCER | ANALOGS | DRUG DISCOVERY | CANCER | MANNICH-BASES | Piperidones - chemical synthesis | Cytotoxins - chemical synthesis | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents, Alkylating - pharmacology | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Piperidones - pharmacology | Poly(ADP-ribose) Polymerases - drug effects | Animals | Benzylidene Compounds - pharmacology | Cytotoxins - pharmacology | Cell Line, Tumor | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Melphalan - pharmacology | Mice | DNA Fragmentation - drug effects | Drug Screening Assays, Antitumor | Index Medicus
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13. Full Text Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis
by Tai, Yu-Tzu and Fulciniti, Mariateresa and Hideshima, Teru and Song, Weihua and Leiba, Merav and Li, Xian-Feng and Rumizen, Matthew and Burger, Peter and Morrison, Aileen and Podar, Klaus and Chauhan, Dharminder and Tassone, Pierfrancesco and Richardson, Paul and Munshi, Nikhil C and Ghobrial, Irene M and Anderson, Kenneth C
Blood, ISSN 0006-4971, 09/2007, Volume 110, Issue 5, pp. 1656 - 1663
Activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signaling cascade mediates human multiple myeloma (MM) growth and survival triggered by... 
Stromal Cells - pathology | RANK Ligand | Phosphorylcholine - analogs & derivatives | Thalidomide - pharmacology | Boronic Acids - therapeutic use | Thalidomide - analogs & derivatives | Cytotoxins - pharmacology | Dexamethasone - pharmacology | Benzimidazoles - therapeutic use | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | Osteoclasts - pathology | Bortezomib | Bone Marrow Cells - pathology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Cell Adhesion - drug effects | Dexamethasone - therapeutic use | Mitogen-Activated Protein Kinase 3 - metabolism | Benzimidazoles - pharmacology | Ligands | Mice | Thalidomide - therapeutic use | Pyrazines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Neoplasm Transplantation | Bone Marrow Cells - enzymology | Transplantation, Heterologous | Pyrazines - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Multiple Myeloma - drug therapy | Stromal Cells - enzymology | Phosphorylcholine - pharmacology | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Cytotoxins - therapeutic use | Macrophage Colony-Stimulating Factor - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | MAP Kinase Signaling System - drug effects | Interleukin-6 - pharmacology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Differentiation - drug effects | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Proliferation - drug effects | Osteoclasts - enzymology | Boronic Acids - pharmacology | Phosphorylcholine - therapeutic use | Neoplasia
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