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d-sotalol (282) 282
index medicus (221) 221
animals (155) 155
cardiac & cardiovascular systems (139) 139
pharmacology & pharmacy (123) 123
anti-arrhythmia agents - pharmacology (110) 110
male (92) 92
humans (91) 91
female (63) 63
dogs (62) 62
action potentials - drug effects (60) 60
sotalol - pharmacology (54) 54
electrocardiography (53) 53
myocardial-infarction (52) 52
arrhythmias (49) 49
anti-arrhythmia agents - therapeutic use (48) 48
in vitro techniques (46) 46
rabbits (46) 46
early afterdepolarizations (44) 44
heart - drug effects (44) 44
amiodarone (42) 42
dofetilide (42) 42
electrophysiology (42) 42
sulfonamides - pharmacology (39) 39
heart conduction system - drug effects (35) 35
arrhythmia (34) 34
repolarization (34) 34
abridged index medicus (30) 30
disease models, animal (29) 29
phenethylamines - pharmacology (29) 29
dose-response relationship, drug (28) 28
torsade-de-pointes (27) 27
left-ventricular dysfunction (26) 26
atrial fibrillation (25) 25
guinea pigs (25) 25
heart ventricles - drug effects (24) 24
torsades-de-pointes (24) 24
action potentials (23) 23
fibrillation (23) 23
guinea-pig (23) 23
heart rate - drug effects (23) 23
long qt syndrome (23) 23
drugs (22) 22
middle aged (22) 22
antiarrhythmic drugs (21) 21
e-4031 (21) 21
electrocardiography - drug effects (21) 21
peripheral vascular disease (21) 21
sotalol (21) 21
time factors (21) 21
ventricular arrhythmias (21) 21
anti-arrhythmia agents - adverse effects (20) 20
heart (20) 20
mortality (20) 20
torsade de pointes (20) 20
torsades de pointes - chemically induced (20) 20
action-potential duration (19) 19
atrial-fibrillation (19) 19
heart - physiology (19) 19
iii antiarrhythmic agents (19) 19
long-qt syndrome (19) 19
myocytes (19) 19
torsades de pointes - physiopathology (19) 19
anti-arrhythmia agents - administration & dosage (18) 18
antiarrhythmic agents (18) 18
atrial fibrillation - drug therapy (18) 18
sotalol - therapeutic use (18) 18
arrhythmias, cardiac - drug therapy (17) 17
cardiovascular system (17) 17
heart conduction system - physiopathology (17) 17
sinus rhythm (17) 17
amiodarone - pharmacology (16) 16
flecainide (16) 16
mechanisms (16) 16
quinidine (16) 16
refractoriness (16) 16
sulfonamides - therapeutic use (16) 16
torsades de pointes (16) 16
aged (15) 15
cardiac arrhythmia (15) 15
electric stimulation (15) 15
hematology (15) 15
pig ventricular myocytes (15) 15
potassium channel blockers (15) 15
purkinje-fibers (15) 15
action-potentials (14) 14
adult (14) 14
efficacy (14) 14
i-kr (14) 14
proarrhythmia (14) 14
tachycardia (14) 14
adrenergic beta-antagonists - pharmacology (13) 13
atrioventricular-block (13) 13
block (13) 13
flutter (13) 13
ibutilide (13) 13
model (13) 13
myocardium - metabolism (13) 13
potassium channels - drug effects (13) 13
refractory period, electrophysiological - drug effects (13) 13
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Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/1999, Volume 341, Issue 12, pp. 857 - 865
Congestive heart failure is a serious disease that can be exacerbated by many factors unrelated to ventricular dysfunction. One important factor in determining... 
ANTIARRHYTHMIC DRUG | MORTALITY | MEDICINE, GENERAL & INTERNAL | D-SOTALOL | THERAPY | MYOCARDIAL-INFARCTION | LOW-DOSE AMIODARONE | ARRHYTHMIA | ATRIAL-FIBRILLATION | RANDOMIZED TRIAL | SINUS RHYTHM | Evaluation | Congestive heart failure | Drug therapy | Complications | Atrial fibrillation | Anti-arrhythmia drugs | Heart failure | Cardiac arrhythmia | Heart attacks
Journal Article
Synlett, ISSN 0936-5214, 06/2011, Volume 2011, Issue 9, pp. 1195 - 1211
Abstract This account shows our efforts towards the development of new N,N-ligands and their application in the asymmetric Henry reaction. Iminopyridine... 
account | N, N -ligands | nitro alcohols | asymmetric catalysis | nucleophilic additions | C symmetry | CATALYSIS | D-SOTALOL | ALPHA-HYDROXY ESTERS | BIS(OXAZOLINE) LIGANDS | INDUCED MYOCARDIAL INJURY | COMPLEXES | CHEMISTRY, ORGANIC | N,N-ligands | KETO ESTERS | ASYMMETRIC NITROALDOL REACTION | C-1-symmetry | STEREOSELECTIVE-SYNTHESIS | ALLYLIC SUBSTITUTIONS
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 06/2018, Volume 137, Issue 2, pp. 237 - 240
We analyzed torsadogenic and pharmacokinetic profile of E-4031 using chronic atrioventricular block dogs. E-4031 in intravenous doses of 0.03, 0.1 and... 
Torsade de pointes | E-4031 | CiPA | DRUG | TORSADES-DE-POINTES | D-SOTALOL | SAFETY | PHARMACOLOGY & PHARMACY | MODEL | ANTIARRHYTHMIC AGENT | Dose-response relationship (Biochemistry) | Drug metabolism | Models | Patient outcomes | Cardiovascular agents | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2007, Volume 151, Issue 7, pp. 941 - 951
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 02/2015, Volume 748, pp. 10 - 17
Torsades de Pointes (TdP) is a potentially lethal cardiac arrhythmia and a known adverse effect of many drugs secondary to block of the rapidly activating... 
PRO-ARRHYTHMIA | Cardiac arrhythmia | Animal model | Action potentials | TORSADES-DE-POINTES | D-SOTALOL | SHORT-TERM VARIABILITY | INFUSION RATE | QT INTERVAL PROLONGATION | VENTRICULAR MYOCYTES | IN-VIVO MODEL | CHANNEL TREK-1 | PHARMACOLOGY & PHARMACY | Adrenergic receptors | ATRIOVENTRICULAR-BLOCK
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 10/2010, Volume 7, Issue 5, pp. 1827 - 1834
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 2010, Volume 21, Issue 5, pp. 578 - 581
A unified approach for the synthesis of ( )-(+)-sotalol and ( )-(−)-isoproterenol has been developed. The enantioselective Henry reaction of the appropriate... 
D-SOTALOL | ASYMMETRIC-SYNTHESIS | INDUCED MYOCARDIAL INJURY | RESOLUTION | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | ISOPROTERENOL | DERIVATIZATION | CHEMISTRY, INORGANIC & NUCLEAR | PERFORMANCE LIQUID-CHROMATOGRAPHY | BETA-ADRENERGIC BLOCKERS | COPPER(II)-IMINOPYRIDINE COMPLEXES | DRUGS
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2016, Volume 81, pp. 183 - 195
Journal Article
Circulation, ISSN 0009-7322, 1996, Volume 94, Issue 7, pp. 1613 - 1621
Background Currently available antiarrhythmic drugs have limited efficacy for acute termination of atrial fibrillation and flutter, especially if the... 
antiarrhythmia agents | ibutilide | arrhythmia | atrial flutter | fibrillation | AMIODARONE | CARDIAC & CARDIOVASCULAR SYSTEMS | D-SOTALOL | FLECAINIDE | VENTRICULAR-TACHYCARDIA | PROCAINAMIDE INFUSION | RECENT-ONSET | DOUBLE-BLIND | PHARMACOLOGIC CONVERSION | PERIPHERAL VASCULAR DISEASE | III ANTIARRHYTHMIC ACTIVITY | SINUS RHYTHM
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2000, Volume 86, Issue 7, pp. 816 - 821
Journal Article