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PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85116
In the current study, we showed that the combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted... 
MAMMALIAN TARGET | BREAST-CANCER | INHIBITION | THERAPY | SIGNALING PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | AKT | PI3K/AKT/MTOR PATHWAY | MTOR | Cyclin D1 - metabolism | Microtubule-Associated Proteins - genetics | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | PTEN Phosphohydrolase - antagonists & inhibitors | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Gastric Mucosa - drug effects | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Beclin-1 | PTEN Phosphohydrolase - genetics | Butadienes - pharmacology | Sirolimus - analogs & derivatives | Adenine - analogs & derivatives | Signal Transduction | Membrane Proteins - genetics | PTEN Phosphohydrolase - metabolism | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Cyclin D1 - genetics | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Biochemistry | Phosphatases | Stomach cancer | Cancer cells | Cancer | TOR protein | Toxicity | Chloroquine | Cytotoxicity | Oncology | Homology | AKT protein | Cyclin D1 | Kinases | Cancer therapies | Autophagy | Proteins | Cell growth | Cell cycle | Inhibition | Growth factors | Gastric cancer | Tensin | Mortality | Extracellular signal-regulated kinase | MAP kinase | Rapamycin | Inhibitors | Cell death | PTEN protein | Phagocytosis
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137210
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors.... 
SIGNAL | PROTEIN | CANCER CELLS | MANTLE CELL LYMPHOMA | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | RESPONSIVE TRANSCRIPTION FACTOR | KINASE | GENE-EXPRESSION | PROLIFERATION | CRM1 | Cyclin D1 - metabolism | Transcription, Genetic - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-pim-1 - metabolism | Elongation Factor 2 Kinase - metabolism | Ribosomes - metabolism | Tumor Suppressor Protein p53 - genetics | Elongation Factor 2 Kinase - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Organelle Biogenesis | Proto-Oncogene Proteins c-bcl-2 - metabolism | Acrylates - pharmacology | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Peptide Elongation Factor 1 - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | HSP70 Heat-Shock Proteins - genetics | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Triazoles - pharmacology | B-Lymphocytes - drug effects | Karyopherins - metabolism | Cyclin D1 - genetics | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ribosomes - drug effects | Cell Line, Tumor | Karyopherins - genetics | Proto-Oncogene Proteins c-pim-1 - genetics | Protein Biosynthesis - drug effects | Proto-Oncogene Proteins c-myc - genetics | Karyopherins - antagonists & inhibitors | Peptide Elongation Factor 1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Genetic aspects | Research | Biological transport | Cell cycle | Ribosomes | Transcription factors | Biomedical research | Transcription | Bcl-2 protein | Laboratories | p53 Protein | Leukemia | c-Myc protein | Multiple myeloma | Immunoblotting | Biosynthesis | Myc protein | Glucose | Cyclin D1 | Cancer therapies | Anticancer properties | Heat shock factors | Proteins | Ribosomal subunits | Cell growth | Translation | Cell survival | Hematology | Hsp70 protein | Gene expression | Lymphoma | Nuclear transport | Molecular chains | Medicine | Molecular modelling | Lymphocytes B | Medical prognosis | Proteomics | Mantle cell lymphoma | Lymphomas | Viability | Heat shock | Apoptosis | Tumors | B-cell lymphoma
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0120045 - e0120045
Cervical cancer is the major cause of cancer related deaths in women, especially in developing countries and Human Papilloma Virus infection in conjunction... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GROWTH-FACTOR-BETA | INVASION | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | PANCREATIC-CANCER | GENE-EXPRESSION | MECHANISMS | HUMAN-PAPILLOMAVIRUS | TRANSCRIPTION FACTOR | Receptors, Transforming Growth Factor beta - genetics | Humans | Collagen - chemistry | Epithelial-Mesenchymal Transition - drug effects | Wnt Proteins - metabolism | Smad4 Protein - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Protein-Serine-Threonine Kinases - metabolism | Emodin - pharmacology | Curcumin - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Smad3 Protein - antagonists & inhibitors | beta Catenin - metabolism | Drug Synergism | Cell Movement - drug effects | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Cyclin D1 - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Laminin - chemistry | HeLa Cells | Cyclin D1 - metabolism | Smad4 Protein - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Smad3 Protein - metabolism | Proteoglycans - chemistry | Smad3 Protein - genetics | Cyclin D1 - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Wnt Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Transforming Growth Factor beta - antagonists & inhibitors | Female | Snail Family Transcription Factors | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | NIMA-Interacting Peptidylprolyl Isomerase | Transcription Factors - genetics | Smad4 Protein - metabolism | beta Catenin - genetics | Transcription Factors - metabolism | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | beta Catenin - antagonists & inhibitors | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Transforming Growth Factor beta - metabolism | Drug Combinations | Biotechnology | Deregulation | Wnt protein | Mesenchyme | Downstream effects | Crosstalk | Viruses | Smad3 protein | Biochemistry | Metastasis | Kinases | Pin1 protein | Cancer therapies | Carcinogenesis | Smad4 protein | Developing countries--LDCs | Cell adhesion & migration | Proteins | β-catenin | Signal transduction | Carcinogens | Pathways | Cell cycle | Curcumin | Tumorigenesis | Inhibition | Downstream | Medical research | Breast cancer | Tumor cell lines | Gene expression | Cervix | Emodin | Signaling | Chemotherapy | Phytochemicals | Cell lines | Ligands | Cell migration | Cervical cancer | Cancer | Apoptosis | Index Medicus | Developing countries | LDCs
Journal Article
The Plant Journal, ISSN 0960-7412, 11/2013, Volume 76, Issue 4, pp. 675 - 686
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2016, Volume 17, Issue 5, pp. 664 - 664
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10290
Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na3VO4 desensitized keratinocytes to UVB-induced... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | TRANSCRIPTION 3 | PROMOTION STAGES | EPITHELIAL CARCINOGENESIS | SUBSTRATE | BIOLOGY | SKIN CARCINOGENESIS | PROLIFERATION | SIGNAL TRANSDUCER | NEGATIVE REGULATOR | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 382, Issue 1, pp. 13 - 25
Cortactin was first identified over a decade ago, and its initial characterization as both an F-actin binding protein and v-Src substrate suggested that it was... 
Actin-related protein (Arp2/3) complex | Cell motility | Endocytosis | Suppressor of cAMP receptor (SCAR)/WASP family verprolin homologous (WAVE) | Wiskott-Aldrich syndrome protein (WASP) | Src | TYROSINE KINASE-ACTIVITY | 11Q13 AMPLIFICATION | family verprolin homologous (WAVE) | actin-related protein (Arp2/3) complex | PRIMARY BREAST-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | ARP2/3 COMPLEX | MODULATE CELL-SHAPE | suppressor of cAMP receptor (SCAR)/WASP | ALDRICH-SYNDROME PROTEIN | TIGHT JUNCTION | cell motility | endocytosis | N-WASP | EXTRACELLULAR-MATRIX | Cortactin | Signal Transduction - physiology | Animals | Actins - physiology | Humans | Microfilament Proteins - physiology | SH, Src homology | 3) complex | WH, WASP homology | EGF, epidermal growth factor | SCAR, suppressor of cAMP receptor | WIP, WASP-interacting protein | NTA, N-terminal acidic (domain) | actin-related protein (Arp2 | GBD, GTPase binding domain | WAVE, WASP family verprolin homologous | PDZ, PSD-95 | WCA, WH2-central–acidic region | Wiskott–Aldrich syndrome protein (WASP) | Hip1R, Huntingtin-interacting protein 1-related | GST, glutathione S-transferase | EVH1, Ena VASP homology 1 | WASP family verprolin homologous (WAVE) | GK(AP), guanylate kinase (associated protein) | HS1, haematopoietic lineage cell-specific protein 1 | ZO-1 | PDGF, platelet-derived growth factor | Dlg | Fgd1, faciogenital dysplasia 1 | NPF, nucleation promoting factor | CortBP1, cortactin binding protein 1 | Arp, actin-related protein | CD2AP, CD2-associated protein | Review | EC MLCK, endothelial cell myosin light-chain kinase | ERK kinase | suppressor of cAMP receptor (SCAR) | WASP, Wiskott–Aldrich syndrome protein | EHEC, enterohaemorrhagic Escherichia coli | N-WASP, neural WASP | PIP2, phosphatidylinositol 4,5 bisphosphate | MEK, MAP kinase | Abp1, actin-binding protein 1 | PAK, p21-activated kinase | ADF-H, actin depolymerizing factor homology | NMDA, N-methyl-D-aspartate | EPEC, enteropathogenic E. coli | ZO-1, zonnula occludens 1 | PSD, post-synaptic density | GEF, guanine nucleotide exchange factor | HP, helical and proline-rich (region) | HGF, hepatocyte growth factor | CCND1, cell cycle regulatory protein cyclin D1
Journal Article
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 12/2012, Volume 367, Issue 1608, pp. 3444 - 3454
Photosystem II (PSII) mutants are useful experimental tools to trap potential intermediates involved in the assembly of the oxygen-evolving PSII complex. Here,... 
Gels | Materials | Antibodies | Thylakoids | Mass spectroscopy | Photosystem II | Biochemistry | Chemical composition | Absorption spectra | Chlorophylls | Psb28 | RC47 | Synechocystis | Accessory factor | Low-molecular-mass subunit | ScpC | CRYSTAL-STRUCTURE | accessory factor | RESOLUTION | SP PCC-6803 | CORE COMPLEX | CAB-LIKE PROTEINS | CYANOBACTERIUM | D1 PROTEIN | THERMOSYNECHOCOCCUS-ELONGATUS | BIOLOGY | low-molecular-mass subunit | REDUCTION KINETICS | CHLOROPHYLL | Electron Transport | Light-Harvesting Protein Complexes - genetics | Molecular Weight | Light-Harvesting Protein Complexes - metabolism | Light-Harvesting Protein Complexes - isolation & purification | Oxygen - metabolism | Photochemical Processes | Holoenzymes - metabolism | Gene Deletion | Photosystem II Protein Complex - genetics | Membrane Proteins - metabolism | Plant Proteins - metabolism | Protein Stability | Synechocystis - genetics | Genes, Bacterial | Oxidation-Reduction | Membrane Proteins - genetics | Electrophoresis, Polyacrylamide Gel | Bacterial Proteins - genetics | Thylakoids - metabolism | Photosystem II Protein Complex - metabolism | Protein Interaction Mapping | Protein Transport | Plant Proteins - genetics | Protein Binding | Bacterial Proteins - metabolism | Holoenzymes - genetics | Bacterial Proteins - isolation & purification | Synechocystis - metabolism | 204
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 17, pp. 3491 - 3500
Proviral integration site for Moloney murine leukemia virus (Pim) kinases are serine/threonine/tyrosine kinases and oncoproteins that promote tumor... 
SIGNALING PATHWAYS | IN-VITRO | MULTIPLE SITES | THERAPEUTIC TARGET | BONE-MARROW | C-MYC | CHRONIC LYMPHOCYTIC-LEUKEMIA | ACUTE MYELOID-LEUKEMIA | CYCLE PROGRESSION | KAPPA-B | HEMATOLOGY | Cell Cycle - genetics | Cyclin D1 - metabolism | RNA, Small Interfering - genetics | Transcription, Genetic - drug effects | Phosphorylation | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-pim-1 - metabolism | Apoptosis - genetics | Pyridazines - pharmacology | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Lymphoma, Mantle-Cell - drug therapy | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Phosphoproteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Cyclin D1 - genetics | Myeloid Cell Leukemia Sequence 1 Protein | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | Protein Biosynthesis - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Lymphoid Neoplasia
Journal Article