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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2007, Volume 320, Issue 1, pp. 1 - 13
Journal Article
Journal of Psychopharmacology, ISSN 0269-8811, 01/2009, Volume 23, Issue 1, pp. 65 - 73
Asenapine is a novel psychopharmacologic agent under development for the treatment of schizophrenia and bipolar disorder. We determined and compared the human... 
Schizophrenia | Affinity | Bipolar disorder | Asenapine | Human receptor | NEGATIVE SYMPTOMS | PSYCHIATRY | FOCUS | SEROTONIN RECEPTORS | DISORDERS | RISPERIDONE | schizophrenia | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | bipolar disorder | DOPAMINE D-3 RECEPTOR | PSYCHOSIS | ATYPICAL ANTIPSYCHOTIC-DRUG | PHARMACOLOGY & PHARMACY | asenapine | human receptor | affinity | Humans | Receptors, Serotonin - drug effects | Substrate Specificity | Receptors, Serotonin - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Psychotropic Drugs - therapeutic use | Receptors, Dopamine - drug effects | Clozapine - pharmacology | Histamine Release - genetics | Receptors, Muscarinic - drug effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Receptors, Adrenergic - drug effects | Psychotropic Drugs - pharmacology | Cloning, Molecular | Receptors, Adrenergic - genetics | Receptors, Dopamine D2 - drug effects | Inhibitory Concentration 50 | Molecular Structure | Radioligand Assay | Histamine Release - drug effects | Receptors, Muscarinic - genetics | Benzodiazepines - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Clinical Trials as Topic | Psychotropic Drugs - chemistry | Bipolar Disorder - drug therapy | Receptors, Dopamine D2 - physiology | Schizophrenia - drug therapy | Receptors, Dopamine - genetics | Histamine receptors | Drugs | Neuroleptics | Olanzapine | Acetylcholine receptors (muscarinic) | Mental disorders | Dopamine D4 receptors | Serotonin S1 receptors | Serotonin S7 receptors | Psychotropic drugs | Receptors | Histamine H2 receptors | Risperidone | Dopamine D2 receptors | Binding | Dopamine | Serotonin | Dopamine D3 receptors | Serotonin S6 receptors | Serotonin S2 receptors | Histamine | Dopamine D1 receptors | Serotonin receptors | Receptors (physiology) | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 2, pp. 395 - 406.e7
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2017, Volume 140, Issue 8, pp. 1870 - 1880
The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study... 
drug resistance | dopamine | tumor stem cells | pituitary adenomas | somatostatin | NEUROENDOCRINE TUMORS | ANALOG | BROMOCRIPTINE | SCINTIGRAPHY | IN-VITRO | THERAPY | ONCOLOGY | CABERGOLINE | STEM-CELL | EXPRESSION | ADENOMAS | Neoplastic Stem Cells - drug effects | Humans | Middle Aged | Spheroids, Cellular - pathology | Neoplasm Recurrence, Local - drug therapy | Male | Neoplasm Recurrence, Local - pathology | Receptors, Somatostatin - genetics | Receptors, Somatostatin - agonists | Adult | DAX-1 Orphan Nuclear Receptor - biosynthesis | Female | Dopamine Agents - administration & dosage | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Gonadotropins - biosynthesis | Pituitary Neoplasms - genetics | Receptors, Dopamine D2 - agonists | Carcinogenesis - genetics | Pituitary Neoplasms - pathology | ERG1 Potassium Channel - biosynthesis | Receptors, Dopamine D2 - genetics | Carcinogenesis - drug effects | Drug Resistance, Neoplasm - genetics | Pituitary Neoplasms - drug therapy | Cyclin D3 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis | RNA Splicing Factors - biosynthesis | Neoplasm Recurrence, Local - genetics | Cell Proliferation - drug effects | Dopamine | Pituitary gland tumors | Analysis | Stem cells | Phenols | Gonadotropin | Drug resistance | Dopamine receptors | Cell proliferation | Drugs | Phenotypes | Transcription factors | Invasiveness | Brain tumors | Dopamine D3 receptors | Pituitary (anterior) | Gonadotropins | Kinases | Cyclin D3 | Pituitary | Agonists | Tumorigenesis | Inhibition | Somatostatin | Dopamine D2 receptors | Tumors
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 45, pp. 35092 - 35103
Journal Article
Journal Article