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Journal of Neuroscience, ISSN 0270-6474, 10/2015, Volume 35, Issue 41, pp. 14017 - 14030
Transient changes in striatal dopamine (DA) concentration are considered to encode a reward prediction error (RPE) in reinforcement learning tasks. Often, a... 
Striatal plasticity | Acetylcholine | Dopamine | D2R/A2AR | Reward learning | D1R/M4R | TONICALLY ACTIVE NEURONS | BASAL GANGLIA | striatal plasticity | SYNAPTIC PLASTICITY | NEUROSCIENCES | MUSCARINIC ACETYLCHOLINE-RECEPTORS | PHASIC DOPAMINE RELEASE | DARPP-32 PHOSPHORYLATION | CHOLINERGIC INTERNEURONS | IN-VIVO | MIDBRAIN DOPAMINE | reward learning | DORSAL STRIATUM | acetylcholine | dopamine | Cyclic AMP-Dependent Protein Kinases - metabolism | Membrane Potentials - drug effects | Neural Pathways - drug effects | Receptors, G-Protein-Coupled - metabolism | Enzyme Inhibitors - pharmacology | Neurotransmitter Agents - metabolism | Adenylyl Cyclases - metabolism | Enzyme Activation - drug effects | Membrane Potentials - physiology | Corpus Striatum - cytology | Neural Pathways - physiology | Animals | Signal Transduction - drug effects | Neurotransmitter Agents - pharmacology | Neurons - physiology | Signal Transduction - physiology | Models, Neurological | Reward | Enzyme Activation - physiology | Dopamine - metabolism | Life Sciences | Cellular Biology | D1R | D2R | M4R | A2AR | SRA - Molekylär biovetenskap | Biological Sciences | Data- och informationsvetenskap | Basic Medicine | Bioinformatik (beräkningsbiologi) | Neurosciences | Medical and Health Sciences | Annan biologi | Medicin och hälsovetenskap | SRA - Molecular Bioscience | Computer and Information Sciences | Naturvetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | acetylcholine; D1R/M4R; D2R/A2AR; dopamine; reward learning; striatal plasticity | Other Biological Topics | Bioinformatics (Computational Biology) | Neurovetenskaper
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 08/2017, Volume 46, Issue 4, pp. 2026 - 2034
The orphan receptor, GPR88, is emerging as a key player in the pathophysiology of several neuropsychiatric diseases, including psychotic disorders. Knockout... 
D2R-medium spiny neurons | schizophrenia | GAP detection | striatum | Cross-modal PPI
Journal Article
Gene, ISSN 0378-1119, 10/2012, Volume 508, Issue 2, pp. 199 - 205
G protein-coupled receptor oligomerization is a concept which is changing the understanding of classical pharmacology. Both, oligomerization and functional... 
Striatal neurons | mGlu5R | Transcriptional profile | A2AR | D2R
Journal Article
CEREBRAL CORTEX, ISSN 1047-3211, 03/2019, Volume 29, Issue 3, pp. 1162 - 1173
Dopamine D-2 receptors (D(2)Rs) contribute to the inverted U-shaped relationship between dopamine signaling and prefrontal function. Genetic networks from... 
DOPAMINERGIC MODULATION | CAPACITY | bromocriptine | D2R | GENOTYPE | prefrontal cortex | SCHIZOPHRENIA | POLYMORPHISM | NEUROSCIENCES | AGONIST BROMOCRIPTINE | gene co-expression networks | WORKING-MEMORY PERFORMANCE | working memory | METHYLPHENIDATE | BRAIN ACTIVATION
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 09/2019, Volume 39, Issue 38, pp. 7551 - 7563
Mental disorders are caused by genetic and environmental factors. We here show that deficiency of an isoform of dopamine D-2 receptor (D2R), D2LR, causes... 
ELECTROSTATIC INTERACTIONS | SYSTEM | DEPRESSION | PET-1 | D2R | ANXIETY | AUTORECEPTORS | NEUROSCIENCES | 5-HT1AR | mental disorders | serotonin | GENE | stress vulnerability | dopamine | BINDING | EXPRESSION | D2L
Journal Article
Hypertension, ISSN 0194-911X, 3/2014, Volume 63, Issue 3, pp. e74 - e80
The dopamine D2 receptor (D 2 R) negatively regulates inflammation in mouse renal proximal tubule cells (RPTCs) and lack or downregulation of the receptor in... 
kidney | dopamine 2 receptor | D2R | renal injury
Journal Article
BIOLOGICAL PSYCHIATRY, ISSN 0006-3223, 06/2016, Volume 79, Issue 11, pp. 887 - 897
BACKGROUND: The dopamine D-2 receptor (D2R) has received much attention in obesity studies. Data indicate that D2R is reduced in obesity and that the TaqA1 D2R... 
Dietary induced obesity | Behavioral thrift | D2R | FOOD-INTAKE | SEDENTARY TIME | DIET-INDUCED OBESITY | REWARD | NEUROSCIENCES | EXERCISE | D2 RECEPTORS | BODY-WEIGHT | Reward deficiency | LIFE-STYLE | MESSENGER-RNA | AVAILABILITY | Voluntary exercise | Running wheels
Journal Article
EUROPEAN JOURNAL OF NEUROSCIENCE, ISSN 0953-816X, 08/2017, Volume 46, Issue 4, pp. 2026 - 2034
The orphan receptor, GPR88, is emerging as a key player in the pathophysiology of several neuropsychiatric diseases, including psychotic disorders. Knockout... 
GAP detection | PREPULSE INHIBITION | SUPERSENSITIVITY | RATS | DISORDERS | schizophrenia | REWARD | NEUROSCIENCES | D2R-medium spiny neurons | OPTOGENETIC CONTROL | striatum | cross-modal PPI | MOTOR BEHAVIORS | MICE | DEFICITS
Journal Article
Neuropharmacology, ISSN 0028-3908, 2014, Volume 76, pp. 498 - 509
Dependence to drugs of abuse is closely associated with impulsivity, or the propensity to choose a lower, but immediate, reward over a delayed, but more... 
Striatum | Impulsivity | Dopamine | Addiction | receptors | Motivation | Imaging | NUCLEUS-ACCUMBENS DOPAMINE | D2R DNA TRANSFER | BRAIN DOPAMINE | NICOTINIC ACETYLCHOLINE-RECEPTORS | NEUROSCIENCES | REACTION-TIME-TASK | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | POSITRON-EMISSION-TOMOGRAPHY | D-2 receptors | IN-VIVO | CHRONIC COCAINE | PHARMACOLOGY & PHARMACY | VENTRAL STRIATUM
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 03/2015, Volume 92, pp. 221 - 235
We describe a novel class of designed multiple ligands (DMLs) combining serotonin 5-HT6 receptor (5-HT6R) antagonism with dopamine D-2 receptor (D2R) partial... 
5-HT6R antagonist | BPSD | SEROTONIN 5-HT6 | DEPRESSION | Designed multiple ligand (DML) | CHEMISTRY, MEDICINAL | PROTEIN | ANXIETY | ALZHEIMERS-DISEASE | DISORDERS | SWISS-MODEL | POTENT | D2R partial agonist | ANTIPSYCHOTIC-DRUGS | LIGAND | Dementia
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 221 - 235
We describe a novel class of designed multiple ligands (DMLs) combining serotonin 5-HT receptor (5-HT R) antagonism with dopamine D receptor (D R) partial... 
5-HT6R antagonist | BPSD | Designed multiple ligand (DML) | D2R partial agonist | Dementia
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 50, pp. E8178 - E8186
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2010, Volume 401, Issue 4, pp. 605 - 610
In view of the co-distribution of dopamine D R and 5-hydroxytryptamine 5-HT receptors (D R and 5-HT R, respectively) within inter alia regions of the dorsal... 
G protein-coupled receptors | receptor | Heteromerization | R receptor | Serotonin 5-HT | Dopamine D | Allosteric modulation | Protein-protein interactions | BIOPHYSICS | Dopamine D2R receptor | RAT | G protein coupled receptors | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUGS | SCHIZOPHRENIA | Serotonin 5 HT2A receptor
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2019, Volume 151, Issue 2, pp. 204 - 226
Journal Article