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Journal of Psychopharmacology, ISSN 0269-8811, 01/2009, Volume 23, Issue 1, pp. 65 - 73
Asenapine is a novel psychopharmacologic agent under development for the treatment of schizophrenia and bipolar disorder. We determined and compared the human... 
Schizophrenia | Affinity | Bipolar disorder | Asenapine | Human receptor | NEGATIVE SYMPTOMS | PSYCHIATRY | FOCUS | SEROTONIN RECEPTORS | DISORDERS | RISPERIDONE | schizophrenia | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | bipolar disorder | DOPAMINE D-3 RECEPTOR | PSYCHOSIS | ATYPICAL ANTIPSYCHOTIC-DRUG | PHARMACOLOGY & PHARMACY | asenapine | human receptor | affinity | Humans | Receptors, Serotonin - drug effects | Substrate Specificity | Receptors, Serotonin - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Psychotropic Drugs - therapeutic use | Receptors, Dopamine - drug effects | Clozapine - pharmacology | Histamine Release - genetics | Receptors, Muscarinic - drug effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Receptors, Adrenergic - drug effects | Psychotropic Drugs - pharmacology | Cloning, Molecular | Receptors, Adrenergic - genetics | Receptors, Dopamine D2 - drug effects | Inhibitory Concentration 50 | Molecular Structure | Radioligand Assay | Histamine Release - drug effects | Receptors, Muscarinic - genetics | Benzodiazepines - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Clinical Trials as Topic | Psychotropic Drugs - chemistry | Bipolar Disorder - drug therapy | Receptors, Dopamine D2 - physiology | Schizophrenia - drug therapy | Receptors, Dopamine - genetics | Histamine receptors | Drugs | Neuroleptics | Olanzapine | Acetylcholine receptors (muscarinic) | Mental disorders | Dopamine D4 receptors | Serotonin S1 receptors | Serotonin S7 receptors | Psychotropic drugs | Receptors | Histamine H2 receptors | Risperidone | Dopamine D2 receptors | Dopamine receptors | Binding | Dopamine | Serotonin | Dopamine D3 receptors | Serotonin S6 receptors | Serotonin S2 receptors | Histamine | Dopamine D1 receptors | Serotonin receptors | Receptors (physiology) | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2006, Volume 103, Issue 31, pp. 11736 - 11741
We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyteselective ablation of retinoid X... 
T lymphocytes | Receptors | Ethanol | Vitamin D | Cytokines | Cholecalciferols | Keratinocytes | Skin | Mast cells | Inflammation | Retinoic acid receptor | Retinoid X receptor | Retinoic acid | Vitamin D receptor | retinoid X receptor | ALLERGIC INFLAMMATION | CELLS | MULTIDISCIPLINARY SCIENCES | skin | NUCLEAR RECEPTOR SUPERFAMILY | retinoic acid receptor | retinoic acid | GENE | ASTHMA | ABLATION | vitamin D receptor | 1,25-DIHYDROXYVITAMIN D-3 | MICE | ASSOCIATION | Skin - cytology | Retinoid X Receptor alpha - metabolism | Calcium - metabolism | Dermatologic Agents - administration & dosage | Humans | Calcitriol - adverse effects | Dermatologic Agents - adverse effects | Receptors, Calcitriol - genetics | Receptors, Retinoic Acid - genetics | Calcitriol - administration & dosage | Calcitriol - analogs & derivatives | Dermatitis, Atopic - chemically induced | Vitamins - immunology | Receptors, Retinoic Acid - agonists | Dermatitis, Atopic - immunology | Female | Cytokines - genetics | Dimerization | Skin - pathology | Cytokines - immunology | Retinoid X Receptor beta - metabolism | Vitamins - chemistry | Cells, Cultured | Retinoid X Receptor beta - genetics | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Keratinocytes - cytology | Receptors, Calcitriol - metabolism | Keratinocytes - immunology | Mice, Knockout | Retinoid X Receptor alpha - agonists | Vitamins - adverse effects | Animals | Retinoid X Receptor alpha - genetics | Mice | Dermatologic Agents - immunology | Administration, Topical | Retinoids - immunology | Skin - drug effects | Vitamins - administration & dosage | Calcitriol - immunology | Retinoid X Receptor beta - agonists | Physiological aspects | Causes of | Vitamin D3 | Atopic dermatitis | Tretinoin | Dermatitis, Atopic | Calcium | Calcitriol | Retinoid X Receptor alpha | Retinoids | Life Sciences | Retinoid X Receptor beta | Receptors, Retinoic Acid | Biochemistry, Molecular Biology | Vitamins | Dermatologic Agents | Receptors, Calcitriol | Molecular biology | Biological Sciences
Journal Article
Neuroscience, ISSN 0306-4522, 05/2019, Volume 406, pp. 563 - 579
Substantia nigra pars reticulata is the output station in basal ganglia; its GABAergic neurons control the activity of thalamo-cortical premotor nuclei, thus... 
D1-like receptors | substantia nigra | subthalamo-nigral pathway | D3 receptors | ACTIVATION | STIMULATION | BASAL GANGLIA | HIGH-AFFINITY | CYCLASE ACTIVITY | NEUROSCIENCES | PROJECTION | SUBTHALAMIC NUCLEUS | GLUTAMATE | NEURONS | PARS RETICULATA | Phenols | GABA | Dopamine | Glutamate | Dopamine receptors
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 01/2003, Volume 50, Issue 1, pp. 5 - 25
The aim of the current study is to investigate whether homology models of G‐Protein‐Coupled Receptors (GPCRs) that are based on bovine rhodopsin are reliable... 
docking | scoring | homology modeling | GPCRs | structure‐based ligand design | Docking | Scoring | Structure-based ligand design | Homology modeling | BETA ADRENERGIC-RECEPTOR | AGONIST ACTIVATION | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-based ligand design | MUSCARINIC RECEPTOR | DELTA-OPIOID RECEPTOR | INDUCED CONFORMATIONAL-CHANGES | TRANSMEMBRANE REGIONS | BIOPHYSICS | SCORING FUNCTIONS | 3-DIMENSIONAL MODELS | BETA-ADRENERGIC RECEPTOR | Humans | Molecular Sequence Data | Heterotrimeric GTP-Binding Proteins - metabolism | Adrenergic beta-2 Receptor Agonists | Receptors, Cell Surface - antagonists & inhibitors | Drug Delivery Systems | Receptors, Adrenergic, beta-2 - chemistry | Receptors, Vasopressin - chemistry | Cattle | Computer Simulation | Receptors, Dopamine D2 - chemistry | Receptors, Cell Surface - chemistry | Databases, Factual | Rhodopsin - chemistry | Amino Acid Sequence | Computational Biology - methods | Receptors, Opioid, delta - chemistry | Receptors, Dopamine D2 - agonists | Receptors, Cell Surface - agonists | Models, Molecular | Receptor, Muscarinic M1 | Receptors, Muscarinic - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Algorithms | Animals | Receptors, Dopamine D3 | Ligands | Antidiuretic Hormone Receptor Antagonists | Dopamine D2 Receptor Antagonists | Receptors, Opioid, delta - agonists
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65860
Dopamine (DA), a neurotransmitter in the nervous system, has been shown to modulate immune function. We have previously reported that five subtypes of DA... 
PROTEIN-KINASE-A | ACTIVATED T-CELLS | NUCLEAR-FACTOR | MULTIDISCIPLINARY SCIENCES | FACTOR-KAPPA-B | PROLIFERATION | SECRETION | MEDIATED MECHANISM | EXPRESSION | LYMPHOCYTES | Enzyme Activators - pharmacology | Phosphorylation | Receptors, Dopamine D3 - metabolism | Receptors, Dopamine D4 - genetics | Receptors, Dopamine D3 - genetics | Isoquinolines - pharmacology | Killer Cells, Natural - immunology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Second Messenger Systems | Cyclic AMP-Dependent Protein Kinases - metabolism | Dopamine Agonists - pharmacology | Gene Expression | Colforsin - pharmacology | Adenylyl Cyclases - metabolism | Benzazepines - pharmacology | Sulfonamides - pharmacology | Mice, Inbred ICR | Animals | Dopamine Antagonists - pharmacology | Cyclic AMP Response Element-Binding Protein - metabolism | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Cell Line, Tumor | Receptors, Dopamine D5 - metabolism | Receptors, Dopamine D4 - metabolism | Protein Processing, Post-Translational | Quinpirole - pharmacology | Receptors, Dopamine D5 - genetics | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic | Phenols | Cyclic adenylic acid | Dopamine | Lymphocytes | Dopamine receptors | Drugs | Flow cytometry | Toxicity | Cytotoxicity | Nervous system | Lymphocytes T | mRNA | Activation | Haloperidol | Kinases | Dopamine D4 receptors | Immunosuppressive agents | Proteins | Signal transduction | Receptors | Cell activation | Modulation | Clonal selection | Physiology | Natural killer cells | Dopamine D2 receptors | Spleen | Dopamine D5 receptors | Adenosine | Immune response | Cytokines | Dopamine D3 receptors | T cell receptors | Cyclic AMP response element-binding protein | Gene expression | Lymphoma | Medicine | Cytometry | Signaling | Dopamine D1 receptors | Forskolin | Receptor mechanisms | Laboratory animals
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2017, Volume 140, Issue 8, pp. 1870 - 1880
The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study... 
drug resistance | dopamine | tumor stem cells | pituitary adenomas | somatostatin | NEUROENDOCRINE TUMORS | ANALOG | BROMOCRIPTINE | SCINTIGRAPHY | IN-VITRO | THERAPY | ONCOLOGY | CABERGOLINE | STEM-CELL | EXPRESSION | ADENOMAS | Neoplastic Stem Cells - drug effects | Humans | Middle Aged | Spheroids, Cellular - pathology | Neoplasm Recurrence, Local - drug therapy | Male | Neoplasm Recurrence, Local - pathology | Receptors, Somatostatin - genetics | Receptors, Somatostatin - agonists | Adult | DAX-1 Orphan Nuclear Receptor - biosynthesis | Female | Dopamine Agents - administration & dosage | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Gonadotropins - biosynthesis | Pituitary Neoplasms - genetics | Receptors, Dopamine D2 - agonists | Carcinogenesis - genetics | Pituitary Neoplasms - pathology | ERG1 Potassium Channel - biosynthesis | Receptors, Dopamine D2 - genetics | Carcinogenesis - drug effects | Drug Resistance, Neoplasm - genetics | Pituitary Neoplasms - drug therapy | Cyclin D3 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis | RNA Splicing Factors - biosynthesis | Neoplasm Recurrence, Local - genetics | Cell Proliferation - drug effects | Dopamine | Pituitary gland tumors | Analysis | Stem cells | Phenols | Gonadotropin | Drug resistance | Dopamine receptors | Cell proliferation | Drugs | Phenotypes | Transcription factors | Invasiveness | Brain tumors | Dopamine D3 receptors | Pituitary (anterior) | Gonadotropins | Kinases | Cyclin D3 | Pituitary | Agonists | Tumorigenesis | Inhibition | Somatostatin | Dopamine D2 receptors | Tumors
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 269 - 273
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal... 
LIGANDS | CLONING | CRYSTAL-STRUCTURE | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | CHARGES | RHODOPSIN | MODEL | BETA-ADRENERGIC RECEPTOR | DISCOVERY | AGONIST | Receptors, Dopamine D4 - chemistry | Humans | Receptors, Dopamine D3 - chemistry | Receptors, Dopamine D3 - metabolism | Mutant Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Mutant Proteins - metabolism | Risperidone - chemistry | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Antipsychotic Agents - chemistry | Mutant Proteins - chemistry | Drug Design | Hydrophobic and Hydrophilic Interactions | Receptors, Dopamine D2 - chemistry | Antipsychotic Agents - metabolism | Ligands | Receptors, Dopamine D4 - metabolism | Risperidone - metabolism | Kinetics | Mutation | Binding Sites | Pharmacology, Experimental | Drug interactions | Physiological aspects | Research | Risperidone | Structure | Dopamine receptors | Drugs | Attention deficit disorder | Neuroleptics | Parkinson's disease | Molecular structure | Mental disorders | Parkinsons disease | Schizophrenia | Mental depression | Proteins | Psychotropic drugs | Receptors | Vomiting | Reinforcement | Dopamine D2 receptors | Movement disorders | Crystal structure | Dopamine | Neurodegenerative diseases | Secretion | Attention deficit hyperactivity disorder | Nausea | Metabolism | Side effects | Addiction | Structure-function relationships
Journal Article
Journal Article
NeuroImage, ISSN 1053-8119, 01/2011, Volume 54, Issue 1, pp. 264 - 277
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0136267
Journal Article