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daphne genkwa (67) 67
pharmacology & pharmacy (36) 36
daphne-genkwa (31) 31
thymelaeaceae (30) 30
daphne - chemistry (29) 29
animals (27) 27
chemistry, medicinal (25) 25
flavonoids (24) 24
humans (18) 18
potent inhibitory-activity (15) 15
flower buds (14) 14
apoptosis (13) 13
mice (13) 13
molecular structure (13) 13
plant sciences (13) 13
yuanhuacine (13) 13
biochemistry & molecular biology (12) 12
cells (12) 12
chemistry, analytical (12) 12
esters (12) 12
male (12) 12
chemistry, multidisciplinary (11) 11
diterpene esters (11) 11
plant extracts - pharmacology (11) 11
chemistry, organic (10) 10
genkwadaphnin (10) 10
rats (10) 10
cytotoxicity (9) 9
daphne (9) 9
diterpenes - chemistry (9) 9
diterpenes - isolation & purification (9) 9
roots (9) 9
toxicity (9) 9
biochemical research methods (8) 8
cancer (8) 8
cell line (8) 8
daphne genkwa sieb. et zucc (8) 8
diterpene (8) 8
diterpenes - pharmacology (8) 8
flowers - chemistry (8) 8
cell line, tumor (7) 7
chemistry, applied (7) 7
constituents (7) 7
flavonoids - pharmacology (7) 7
flos (7) 7
genkwanin (7) 7
growth (7) 7
inflammation (7) 7
integrative & complementary medicine (7) 7
luteolin (7) 7
magnetic resonance spectroscopy (7) 7
plant roots - chemistry (7) 7
analysis (6) 6
anti-tumor agents (6) 6
apigenin (6) 6
cell proliferation - drug effects (6) 6
cell survival - drug effects (6) 6
diterpenes (6) 6
flavonoid (6) 6
in-vitro (6) 6
metabolism (6) 6
molecular conformation (6) 6
plant extracts (6) 6
stereochemistry (6) 6
activation (5) 5
agents (5) 5
chromatography (5) 5
daphnane-type diterpene (5) 5
female (5) 5
flavones (5) 5
flowers (5) 5
immunology (5) 5
lipopolysaccharides (5) 5
lymphocytic-leukemia cells (5) 5
pharmacokinetics (5) 5
tissue distribution (5) 5
toxicology (5) 5
traditional chinese medicine (5) 5
antineoplastic agents, phytogenic - pharmacology (4) 4
arthritis (4) 4
bioflavonoids (4) 4
chromatography, high pressure liquid (4) 4
dose-response relationship, drug (4) 4
drugs, chinese herbal - chemistry (4) 4
expression (4) 4
extract (4) 4
flavonoids - chemistry (4) 4
flavonoids - isolation & purification (4) 4
genkwa (4) 4
genkwa flos (4) 4
health aspects (4) 4
hydroxygenkwanin (4) 4
inhibition (4) 4
isoflavones (4) 4
lignans (4) 4
lung neoplasms - drug therapy (4) 4
macrophages (4) 4
mass spectrometry (4) 4
medicine, botanic (4) 4
medicine, herbal (4) 4
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Planta Medica, ISSN 0032-0943, 11/2019, Volume 85, Issue 16, pp. 1275 - 1286
Abstract Breast cancer is one of the most common cancers diagnosed among women worldwide. Estrogen receptor alpha (ER α ) is a transcriptional factor that... 
Natural Product Chemistry and Analytical Studies | CHEMISTRY, MEDICINAL | DITERPENE ESTERS | REACTIVE OXYGEN | Daphne genkwa | Thymelaeaceae | INTEGRATIVE & COMPLEMENTARY MEDICINE | estrogen receptor alpha | breast cancer | apoptosis | PHARMACOLOGY & PHARMACY | MECHANISMS | PLANT SCIENCES | Index Medicus
Journal Article
Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, 04/2014, Volume 37, Issue 6, pp. 773 - 785
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 3828 - 13
Journal Article
Journal Article
Synlett, ISSN 0936-5214, 2012, Volume 23, Issue 15, pp. 2227 - 2230
Abstract The reaction of formylchromones with alkyl isocyanides was reinvestigated. In earlier reports from other research groups, two different structures... 
letter | multicomponent reactions | natural products | fused-ring systems | cycloaddition reactions | heterocycles | furans | DAPHNE-GENKWA | ONE-POT SYNTHESIS | CHEMISTRY, ORGANIC | LIBRARIES | ACID-DERIVATIVES | FACILE SYNTHESIS | PRODUCT | CHEMISTRY | DAPHNODORINS | CONSTITUENTS
Journal Article
MOLECULES, ISSN 1420-3049, 02/2020, Volume 25, Issue 4, p. 941
Epidermal growth factor receptor (EGFR) is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC), which is the major type of lung cancer.... 
DAPHNE-GENKWA | NSCLC | TOTAL FLAVONOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | CHEMISTRY, MULTIDISCIPLINARY | EGFR | GROWTH-FACTOR RECEPTOR | Daphne genkwa | RESISTANCE | MUTATIONS | CARCINOMA | DITERPENE | hydroxygenkwanin | FLOWER BUDS | egfr | nsclc | daphne genkwa
Journal Article
PloS one, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e115146
The flower buds of Daphne genkwa Sieb. et Zucc. have been used as a traditional Chinese medicine although their functional mechanisms have not been discovered... 
DAPHNE-GENKWA | VIRUS-INFECTION | INTERFERON-GAMMA | DIRECT STIMULATION | INNATE IMMUNE-RESPONSES | IL-18 | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | NK-CELLS | ACTIVATING RECEPTORS | NF-KAPPA-B | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Killer Cells, Natural - pathology | Interferon-gamma - metabolism | Lymphoma - metabolism | Lymphoma - drug therapy | STAT1 Transcription Factor - metabolism | Lymphoma - pathology | Gene Expression Regulation, Neoplastic - drug effects | Interferon-gamma - genetics | Phosphorylation - drug effects | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | TRPP Cation Channels - metabolism | Diterpenes - pharmacology | NF-kappa B - antagonists & inhibitors | Enzyme-Linked Immunosorbent Assay | TRPP Cation Channels - antagonists & inhibitors | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - antagonists & inhibitors | Blotting, Western | TRPP Cation Channels - genetics | NF-kappa B - genetics | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Biotechnology | Phosphorylation | Protein kinase C | Transcription | Genomics | Cytotoxicity | Infections | Activation | Feedback loops | Kinases | Positive feedback | Proteins | Cell activation | Cell cycle | Autocrine signalling | Natural killer cells | Localization | Stat1 protein | Elongation | NF-κB protein | Antigens | Cytokines | Secretion | Traditional Chinese medicine | Extracellular signal-regulated kinase | Plant extracts | Inhibitors | γ-Interferon | Interferon | Viral infections | Cancer
Journal Article
Chemistry Central Journal, ISSN 1752-153X, 12/2013, Volume 7, Issue 1, pp. 1 - 9
Flos Genkwa (yuanhua in Chinese), the dried flower buds of Daphne genkwa Sieb.et Zucc. (Thymelaeaceae), is a traditional Chinese medicinal herb mainly used for... 
Western blot | Chemistry | Daphne genkwa | Chemistry/Food Science, general | Antitumor | Flow cytometric | MTT | CELLS | APOPTOSIS | DAPHNORETIN | CHEMISTRY, MULTIDISCIPLINARY | ARREST | ROOTS | AGENTS | DITERPENE | Proteins | Medical research | Chinese medicine | Ethanol | Cytotoxicity | Experiments | Cancer | Partitioning | Peptides | Medicinal herbs | Dichloromethane | Diuretics | Flowers | Ethers
Journal Article
Molecular medicine reports, ISSN 1791-2997, 08/2015, Volume 12, Issue 2, pp. 2348 - 2354
Rhizoma Atractylodes macrocephala, Radix Isatidis, Coptis chinensis and Flos Genkwa are common herbal remedies used by pregnant woman in China. In this study,... 
MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | DAPHNE-GENKWA | ONCOLOGY | embryotoxicity | VALIDATION | RATS | traditional Chinese medicine | TOXICITY | embryonic stem cell test | PREGNANCY
Journal Article
Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, 11/2011, Volume 34, Issue 19, pp. 2360 - 2372
Journal Article
Journal Article
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ISSN 1570-0232, 03/2018, Volume 1079, pp. 34 - 40
A sensitive UHPLC–MS/MS approach was developed and validated for the quantification of genkwanin, 3′-hydroxygenkwanin, apigenin, luteolin, yuanhuacine and... 
Daphne genkwa | UHPLC-MS/MS | Vinegar | Pharmacokinetics | CHEMISTRY, ANALYTICAL | BUPLEURI | PLASMA APPLICATION | RADIX | BIOCHEMICAL RESEARCH METHODS | FLOS | FLAVONOIDS | TOXICITY | TANDEM MASS-SPECTROMETRY | PROFILE
Journal Article