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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2017, Volume 8, Issue 1, pp. 43 - 48
We describe the incorporation of a bicyclo[1.1.1]­pentane moiety within two known LpPLA2 inhibitors to act as bioisosteric phenyl replacements. An efficient... 
Physicochemical | LpPLA2 | Cardiovascular disease | Bioisostere | Darapladib | Bicyclo[1.1.1]pentane
Journal Article
European heart journal, ISSN 1522-9645, 2014, Volume 35, Issue 27, pp. 1782 - 1791
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the initiation and progression of... 
Darapladib | Atherosclerosis | Inflammasome | Inflammation | Colchicine | Salsalate | C reactive protein | Canakinumab | Methotrexate | Interleukin-6 | C-REACTIVE PROTEIN | FUTURE MYOCARDIAL-INFARCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | RANDOMIZED CLINICAL-TRIAL | SECRETORY PHOSPHOLIPASE A | ACUTE CORONARY SYNDROME | APPARENTLY HEALTHY-MEN | REVERSE CHOLESTEROL TRANSPORT | PLACEBO-CONTROLLED TRIAL | TYPE-2 DIABETES-MELLITUS | Hydroxychloroquine - therapeutic use | Interleukin-6 - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein | Colchicine - therapeutic use | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Methotrexate - therapeutic use | Sirtuins - therapeutic use | Vaccination - methods | Lipoproteins, HDL - drug effects | Interleukin-1 - physiology | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Interleukin-1 - antagonists & inhibitors | Leukotriene Antagonists - therapeutic use | Carrier Proteins - physiology | Adaptive Immunity - physiology | Phospholipase A2 Inhibitors - therapeutic use | Atherosclerosis - drug therapy | Serpins - therapeutic use | C-Reactive Protein - physiology | Antioxidants - therapeutic use | Tumor Necrosis Factor-alpha - drug effects | Signal Transduction - drug effects | Tumor Necrosis Factor-alpha - physiology | Thrombosis - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Review
Journal Article
Expert Review of Cardiovascular Therapy, ISSN 1477-9072, 01/2015, Volume 13, Issue 1, pp. 33 - 48
Elevated levels of phospholipase A2 have been linked to atherosclerotic plaque progression, instability via promoting inflammation and subsequent acute... 
atherosclerosis | darapladib | inflammation | phospholipase A2
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 70, Issue 14, pp. 1689 - 1700
Journal Article
European journal of preventive cardiology, ISSN 2047-4873, 03/2017, Volume 24, Issue 5, pp. 492 - 504
textabstractAims Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes... 
coronary heart disease | darapladib | target validation | lipoprotein-associated phospholipase A2 | Human genetics | lipoprotein-associated phospholipase A | Coronary Heart Disease
Journal Article
Journal Article
European Journal of Preventive Cardiology, ISSN 2047-4873, 3/2017, Volume 24, Issue 5, pp. 489 - 491
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 2017, Volume 6, Issue 10, p. n/a
Background It is unknown whether short sleep duration, obstructive sleep apnea, and overnight shift work are associated with the risk of recurrent... 
night shift | obstructive sleep apnea | sleep | sleep disorders | cardiovascular risk | Sleep disorders | Sleep | Obstructive sleep apnea | Night shift | Cardiovascular risk | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | MYOCARDIAL-INFARCTION | PREVALENCE | DARAPLADIB | ALL-CAUSE MORTALITY | HEART-DISEASE | WORK | HEALTH | HYPERTENSION | ASSOCIATION
Journal Article
Medicine (Baltimore), ISSN 0025-7974, 2018, Volume 97, Issue 28, p. e11517
Journal Article
Journal of Thoracic Disease, ISSN 2072-1439, 2016, Volume 8, Issue 9, pp. 2328 - 2330
Journal Article