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European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 08/2019, Volume 141, pp. 37 - 50
Specific cell targeting and efficient intracellular delivery are major hurdles for the widespread therapeutic use of nucleic acid technologies, particularly... 
Endocytosis | Bioconjugation | siRNA | Targeting | DARPins | LIPID NANOPARTICLES | REPEAT PROTEINS DARPINS | ANKYRIN | ASIALOGLYCOPROTEIN RECEPTOR | INTERNALIZATION | IMPACT | AFFINITY | PHARMACOLOGY & PHARMACY | Crosslinked polymers | Cysteine | Thiols | Triazoles | Genes | Genetic engineering | Nucleic acids | Fluorescence microscopy | Cystine
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2019, Volume 431, Issue 15, pp. 2852 - 2868
Recombinant therapeutic proteins are playing an ever-increasing role in the clinic. High-affinity binding candidates can be produced in a high-throughput... 
homology modeling | protein–protein docking | DARPin | ClusPro | Rosetta | protein-protein docking | DOCKING | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONFORMATIONAL FLEXIBILITY | DARPINS | POTENTIALS | SIMULATION | PREDICTION | BACKBONE | BINDING | WEB SERVER | Proteins | Computer-generated environments | Computer simulation | Analysis
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10
Proteins smaller than about 50 kDa are currently too small to be imaged at high resolution by cryo-electron microscopy (cryo-EM), leaving most protein... 
SYSTEM | GFP | DESIGN | MULTIDISCIPLINARY SCIENCES | COMBINATORIAL LIBRARIES | DARPINS | ANKYRIN REPEAT PROTEINS | MOLECULES
Journal Article
ACS Applied Materials & Interfaces, ISSN 1944-8244, 05/2018, Volume 10, Issue 20, pp. 17437 - 17447
Nanoparticle surface engineering can change its chemical identity to enable surface coupling with functional biomolecules. However, common surface coupling... 
Research | CELLS | DESIGN | Barnase | DARPin | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | DARPINS | targeted delivery | NANOSCIENCE & NANOTECHNOLOGY | cancer cells | HER2/neu | bioengineering | DISPLAY | MODULE | nanoparticle modification | Barstar | UP-CONVERSION NANOPARTICLES | THERANOSTICS | NANOTECHNOLOGY | BINDING PEPTIDES
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 13, pp. 3362 - 3367
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 03/2019, Volume 16, Issue 3, pp. 995 - 1008
Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins that can be selected for binding to desirable molecular targets. High... 
Tc-99m | I-125 | targeting | DARPin | imaging | radionuclide | MEDICINE, RESEARCH & EXPERIMENTAL | REPEAT PROTEINS DARPINS | AFFIBODY MOLECULES | BIODISTRIBUTION | HISTIDINE-CONTAINING TAGS | BINDING-PROTEINS | BREAST-CANCER | IN-VITRO | POSITRON-EMISSION-TOMOGRAPHY | I-12S | HER2 EXPRESSION | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR
Journal Article
Tuberculosis, ISSN 1472-9792, 09/2019, Volume 118, p. 101852
Tuberculosis (TB), a life threatening communicable disease, is mainly caused by the bacterium named ( ). This high burden infectious threat is the ninth... 
GMR (Giant Magnetoresistance) | Tuberculosis | ESAT-6 | GNP (Gold Nanoparticles) | DARPins | ELISA
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 10, pp. 2020 - 2039
MET, the product of the proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation and migration during... 
X-ray crystallography | biparatopic | protein engineering | MET | DARPins | Proteins | Growth | Analysis | Crystals | Metastasis | Structure | Cancer | Antigenic determinants
Journal Article
Toxicological Sciences, ISSN 1096-6080, 07/2019, Volume 170, Issue 1, pp. 123 - 132
Abstract Upconversion nanoparticles (UCNPs) are new-generation photoluminescent nanomaterials gaining considerable recognition in the life sciences due to... 
animal imaging | DRUG-DELIVERY | pharmacodynamics | pharmacokinetics | DARPINS | upconversion nanoparticles | TOXICITY | BIODISTRIBUTION | TOXICOLOGY | photoluminescent nanomaterials | nanotoxicology
Journal Article
Journal of Mazandaran University of Medical Sciences, ISSN 1735-9279, 2017, Volume 27, Issue 151, pp. 12 - 23
Journal Article
Biochemical Engineering Journal, ISSN 1369-703X, 08/2019, Volume 148, pp. 1 - 8
Designed ankyrin repeat proteins (DARPins) are a kind of proteins containing the similar characteristics to antibodies. Which can specifically bind the target... 
PD-L1 | Direct evolution | Immunity check point reagent | DARPin | Surface display | SYSTEM | CELLS | DARPINS | MPDL3280A | ENGINEERING, CHEMICAL | ANTI-PD-L1 ANTIBODY | AFFINITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SELECTION | Animal experimentation | Proteins | Viral antibodies | Antigens | Biological products | Chemical tests and reagents | Immunotherapy | Escherichia coli | Antibodies
Journal Article
Biology open, ISSN 2046-6390, 10/2018, Volume 7, Issue 11
Over the last few years, protein-based affinity reagents have proven very helpful in cell and developmental biology. While many of these versatile small... 
Relocalization | Protein binder | mTFP1 | DARPins | Crystal structure
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1 - 11
Multivalent binding proteins can gain biological activities beyond what is inherent in the individual binders, by bringing together different target molecules,... 
CRYSTALLIZATION | LIBRARIES | CELLS | DESIGN | ACTIVATION | STABILIZATION | MULTIDISCIPLINARY SCIENCES | DARPINS | ANKYRIN REPEAT PROTEINS | HER2 | BINDING-PROTEINS | X-ray crystallography | Proteins | Ankyrin | Localization | Protein structure | Crystallography
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 03/2015, Volume 202, pp. 14 - 20
The modification of liposomal surfaces is of interest for many different applications and a variety of chemistries are available that makes this possible. A... 
Liposomes | Strain-promoted azido-alkyne cycloaddition | Site specific conjugation | Copper-free click chemistry | DARPins
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 8, pp. 2121 - 2131.e5
The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by... 
antibody design | IL-17A | protein modeling | in silico protein design | YEAST | SYSTEM | DOCKING | SURFACE | DARPINS | RECEPTOR | BINDING-PROTEINS | PEPTIDE | CELL BIOLOGY
Journal Article