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davis-beirut reaction (9) 9
chemistry, organic (6) 6
chemistry, medicinal (4) 4
2h-indazoles (3) 3
3-alkoxy-2h-indazoles (3) 3
article (3) 3
humans (3) 3
indazoles - chemistry (3) 3
index medicus (3) 3
n bond formation (3) 3
route (3) 3
2h-indazole (2) 2
3-substituted indazoles (2) 2
antineoplastic agents - chemistry (2) 2
antipsychotic (2) 2
antiretroviral (2) 2
antitumor (2) 2
axitinib (2) 2
benzimidazole derivatives (2) 2
biological-activity (2) 2
catalyzed coupling reactions (2) 2
cell proliferation - drug effects (2) 2
cells (2) 2
chronic pain (2) 2
davis–beirut reaction (2) 2
derivatives (2) 2
efficient synthesis (2) 2
narcotic (2) 2
regioselective synthesis (2) 2
substituted 1h-indazoles (2) 2
1-acyl 2-aryl 3h-indazol-3-ones (1) 1
1h-indazolones (1) 1
2h-indazole derivatives (1) 1
acid (1) 1
agents (1) 1
aldehydes (1) 1
alzheimer disease - drug therapy (1) 1
aminocarbonylation (1) 1
analysis (1) 1
animals (1) 1
antidepressants (1) 1
antineoplastic agents - chemical synthesis (1) 1
antineoplastic agents - pharmacology (1) 1
antineoplastic agents - toxicity (1) 1
antipsychotic agents - chemical synthesis (1) 1
antipsychotic agents - chemistry (1) 1
antipsychotic agents - pharmacology (1) 1
antipyretic activity (1) 1
aryl iodides (1) 1
azo-compounds (1) 1
azobenzenes (1) 1
binding sites (1) 1
biochemistry & molecular biology (1) 1
biological activity (1) 1
bond (1) 1
c-n (1) 1
carbon-monoxide (1) 1
cardiovascular diseases - drug therapy (1) 1
catalysis (1) 1
catalytic domain (1) 1
chemical reactions (1) 1
chemical synthesis (1) 1
chemistry (1) 1
chloramines - chemistry (1) 1
chloramines - metabolism (1) 1
chronic pain - drug therapy (1) 1
computational docking (1) 1
conformer generation (1) 1
coupling (1) 1
cross coupling (1) 1
cyclization (1) 1
cyclizative carbonylation (1) 1
cystic-fibrosis (1) 1
density functional theory (1) 1
design (1) 1
disease (1) 1
estrogens (1) 1
ethnopharmacological survey (1) 1
ferric oxide (1) 1
fertilization - drug effects (1) 1
functionalization (1) 1
heterocyclic compounds (1) 1
heterocyclization (1) 1
hyaluronan (1) 1
hyaluronic acid (1) 1
hypertension (1) 1
in silico toxicity (1) 1
in-vitro (1) 1
indazole (1) 1
indazoles (1) 1
indazoles - chemical synthesis (1) 1
indazoles - metabolism (1) 1
indazoles - pharmacology (1) 1
indazoles - therapeutic use (1) 1
indazoles - toxicity (1) 1
indazolone (1) 1
inhibitors (1) 1
innate (1) 1
iron compounds (1) 1
iron oxide nanoparticles (1) 1
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1. Full Text Access to 2-substituted-2H-indazoles via a copper-catalyzed regioselective cross-coupling reaction
by Zhang, R and Liu, Z and Peng, QJ and Zhou, YJ and Xu, LT and Pan, XH
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 03/2018, Volume 16, Issue 11, pp. 1816 - 1822
A CuCl catalyzed C-N cross-coupling reaction using commercially available 1H-indazoles with diaryliodonium salts is described. The methodology features ample... 
TRIETHYL PHOSPHITE | FUNCTIONALIZATION | INDAZOLE | NITROGEN-HETEROCYCLES | 2H-INDAZOLES | C-N | AZOBENZENES | CHEMISTRY, ORGANIC | N BOND FORMATION | DAVIS-BEIRUT REACTION | CYCLIZATION | Substitutes | Oxidation process | Cross coupling | Salts | Regioselectivity | Estrogens | Chemical reactions | Density functional theory | Oxidation | Coupling | Chemical synthesis
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2. Full Text Acid and base catalyzed Davis–Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles
by Avila, Belem and El-Dakdouki, Mohammad H and Nazer, Musa Z and Harrison, Jason G and Tantillo, Dean J and Haddadin, Makhluf J and Kurth, Mark J
Tetrahedron Letters, ISSN 0040-4039, 11/2012, Volume 53, Issue 48, pp. 6475 - 6478
The Davis–Beirut reaction, which provides an efficient synthesis of 2 -indazoles and, subsequently, indazolones, is shown to proceed rapidly from... 
Catalysis | o-Nitrosobenzaldehyde | 2H-Indazole | Mechanism | Davis–Beirut reaction | Davis-Beirut reaction | ROUTE | CHEMISTRY, ORGANIC | 2H-indazole | catalysis | o-nitrosobenzaldehyde | mechanism
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3. Full Text Synthesis of novel 2H-indazole analogues via the Davis-Beirut reaction and conjugation onto magnetic nanoparticles
by El-Dakdouki, Mohammad H and Hussein, AbdulSattar and Abdallah, Hiba and Shatila, Rania and Mouneimne, Youssef
Tetrahedron, ISSN 0040-4020, 09/2017, Volume 73, Issue 39, pp. 5769 - 5777
Methods for the construction of C3-amino substituted 2 -indazole motifs are scarce. While the Davis-Beirut reaction proved useful and versatile in the... 
In silico toxicity | Davis-Beirut reaction | Iron oxide nanoparticles | 2H-indazoles | Hyaluronic acid | CELLS | 3-ALKOXY-2H-INDAZOLES | INDAZOLES | CHEMISTRY, ORGANIC | HYALURONAN | BOND | DERIVATIVES | Nanoparticles | Analysis | Iron compounds | Ferric oxide
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4. The davis-beirut reaction: A novel entry into 2h-indazoles and indazolones. Recent biological activity of indazoles
by Haddadin, Makhluf J and Conrad, Wayne E and Kurth, Mark J
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2012, Volume 12, Issue 12, pp. 1293 - 1300
A novel, easy method for the syntheses of richly diversified 2H-indazoles and indazolones, called the Davis-Beirut reaction, and other recent 2H-indazole... 
Indazolone | 2H-indazoles | Biological activity | Davis-beirut reaction | 1H-INDAZOLONES | Davis-Beirut reaction | ROUTE | CELLS | 3-ALKOXY-2H-INDAZOLES | CHEMISTRY, MEDICINAL | NITRIC-OXIDE SYNTHASE | NUCLEOPHILIC-SUBSTITUTION | IN-VITRO | Biological Activity | AGENTS | INHIBITORS | DERIVATIVES | Indazoles - chemistry | Cardiovascular Diseases - drug therapy | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Antineoplastic Agents - chemistry | Isomerism | Antineoplastic Agents - toxicity | Animals | Fertilization - drug effects | Indazoles - toxicity | Cell Proliferation - drug effects | Nitric Oxide Synthase - metabolism | Indazoles - therapeutic use
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5. Full Text N–N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2‑Substituted Indazolones with Mechanistic Insights
by Zhu, Jie S and Kraemer, Niklas and Shatskikh, Marina E and Li, Clarabella J and Son, Jung-Ho and Haddadin, Makhluf J and Tantillo, Dean J and Kurth, Mark J
Organic Letters, ISSN 1523-7060, 08/2018, Volume 20, Issue 16, pp. 4736 - 4739
A concise, one-step route to indazolones from primary alkyl amines and o-nitrobenzyl alcohols is reported. The key step in this readily scalable indazolone... 
CHEMISTRY | CHEMISTRY, ORGANIC | HETEROCYCLIZATION | 3-ALKOXY-2H-INDAZOLES | DAVIS-BEIRUT REACTION
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6. Full Text Synthesis of indazole motifs and their medicinal importance: An overview
by Gaikwad, Digambar D and Chapolikar, Archana D and Devkate, Chandrashekhar G and Warad, Khandu D and Tayade, Amit P and Pawar, Rajendra P and Domb, Abraham J
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 707 - 731
Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the... 
Antiretroviral | Axitinib | Antipsychotic | Narcotic | Chronic pain | Antitumor | CHEMISTRY, MEDICINAL | BENZIMIDAZOLE DERIVATIVES | EFFICIENT SYNTHESIS | ETHNOPHARMACOLOGICAL SURVEY | CATALYZED COUPLING REACTIONS | SUBSTITUTED 1H-INDAZOLES | 3-SUBSTITUTED INDAZOLES | BIOLOGICAL-ACTIVITY | REGIOSELECTIVE SYNTHESIS | N BOND FORMATION | DAVIS-BEIRUT REACTION | Chronic Pain - drug therapy | Indazoles - chemistry | Indazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Alzheimer Disease - drug therapy | Antineoplastic Agents - chemistry | Narcotics - chemical synthesis | Antipsychotic Agents - chemical synthesis | Indazoles - pharmacology | Narcotics - chemistry | Antipsychotic Agents - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Antipsychotic Agents - pharmacology | Narcotics - pharmacology | Hypertension | Jewish schools | Antidepressants | Heterocyclic compounds
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7. Full Text Inhibition of myeloperoxidase: Evaluation of 2H-indazoles and 1H-indazolones
by Roth, Aaron and Ott, Sean and Farber, Kelli M and Palazzo, Teresa A and Conrad, Wayne E and Haddadin, Makhluf J and Tantillo, Dean J and Cross, Carroll E and Eiserich, Jason P and Kurth, Mark J
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 22, pp. 6422 - 6429
Myeloperoxidase (MPO) produces hypohalous acids as a key component of the innate immune response; however, release of these acids extracellularly results in... 
Computational docking | Myeloperoxidase | 2H-Indazole | Structure–activity relationship | Davis–Beirut reaction | Davis-Beirut reaction | Structure-activity relationship | ROUTE | DESIGN | CHEMISTRY, MEDICINAL | CONFORMER GENERATION | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | CHEMISTRY, ORGANIC | MECHANISMS | DISEASE | CYSTIC-FIBROSIS | Peroxidase - antagonists & inhibitors | Catalytic Domain | Indazoles - chemistry | Humans | Chloramines - metabolism | Indazoles - metabolism | Structure-Activity Relationship | Chloramines - chemistry | Protein Binding | Molecular Docking Simulation | Taurine - chemistry | Binding Sites | Taurine - metabolism | Peroxidase - metabolism | 2H-indazole
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8. Full Text Palladium-catalyzed cyclizative carbonylation of azobenzenes toward 3H-Indazol-3-ones using formic acid as CO source
by Gu, Ning and Sun, Song and Cheng, Jiang
Tetrahedron Letters, ISSN 0040-4039, 03/2018, Volume 59, Issue 11, pp. 1069 - 1072
A palladium-catalyzed cyclizative carbonylation of azobenzenes has been developed to access 1-acyl 2-aryl 3 -indazol-3-ones in moderate to good yields with... 
Cyclizative carbonylation | 1-Acyl 2-aryl 3H-indazol-3-ones | Palladium-catalyzed | Ortho-C–H functionalization | CHEMISTRY, ORGANIC | ALDEHYDES | Ortho-C-H functionalization | NONSTEROIDAL ANTIINFLAMMATORY AGENTS | AZO-COMPOUNDS | CARBON-MONOXIDE | PARAFORMALDEHYDE | N BOND FORMATION | ARYL IODIDES | AMINOCARBONYLATION | DAVIS-BEIRUT REACTION | ANTIPYRETIC ACTIVITY
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9. Full Text Synthesis of indazole motifs and their medicinal importance: An overview
by Gaikwad, DD and Chapolikar, AD and Devkate, CG and Warad, KD and Tayade, AP and Pawar, RP and Domb, AJ
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 11/2014, Volume 87, pp. 707 - 731
Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the... 
CHEMISTRY, MEDICINAL | BENZIMIDAZOLE DERIVATIVES | Narcotic | Antiretroviral | EFFICIENT SYNTHESIS | KINASE INHIBITORS | CATALYZED COUPLING REACTIONS | Chronic pain | SUBSTITUTED 1H-INDAZOLES | 3-SUBSTITUTED INDAZOLES | Antitumor | BIOLOGICAL-ACTIVITY | REGIOSELECTIVE SYNTHESIS | Axitinib | Antipsychotic | DAVIS-BEIRUT REACTION | 2H-INDAZOLE DERIVATIVES
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