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PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e115579
Vision loss in glaucoma is caused by progressive dysfunction of retinal ganglion cells (RGCs) and optic nerve atrophy. Here, we investigated the effectiveness... 
RECEPTOR TRKB | OPTIC-NERVE INJURY | VISUAL-ACUITY | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | DBA/2J MOUSE | AXONAL-TRANSPORT | MICE | GROWTH-FACTOR | PATTERN ELECTRORETINOGRAM | GANGLION-CELL SURVIVAL | Electroretinography | Retina - drug effects | Administration, Ophthalmic | Intraocular Pressure - drug effects | Intravitreal Injections | Rats, Wistar | Humans | Mice, Inbred C57BL | Retina - physiopathology | Glaucoma - drug therapy | Transcription Factor Brn-3A - metabolism | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - pathology | Brain-Derived Neurotrophic Factor - administration & dosage | Brain-Derived Neurotrophic Factor - pharmacology | Animals | Evoked Potentials, Visual - drug effects | Mice, Inbred DBA | Brain-Derived Neurotrophic Factor - therapeutic use | Retina - pathology | Glaucoma - physiopathology | Retinal Ganglion Cells - drug effects | Disease Models, Animal | Hypertension | Glaucoma | Physiological aspects | Analysis | Enzyme-linked immunosorbent assay | Neurosciences | Physiological effects | Retina | Visual evoked potentials | Confocal | Visual perception | Eye | Atrophy | Reduction | Rodents | Physiology | Ganglion cells | Growth factors | Age | Recombinant | Optic nerve | Cortex | Injection | Sodium chloride | Electroretinograms | Retinal ganglion cells | Brain research | Brain-derived neurotrophic factor | Councils | Visual impairment | Vision | Mice | Laboratory animals | Apoptosis | Intraocular pressure
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 01/2014, Volume 55, Issue 2, pp. 993 - 1005
PURPOSE. To test whether a diet supplemented with coenzyme Q10 (CoQ10) ameliorates glutamate excitotoxicity and oxidative stress-mediated retinal ganglion cell... 
Glaucoma | Oxidative stress | Coenzyme Q10 | Excitotoxicity | Mitochondrial alteration | mitochondrial alteration | coenzyme Q10 | LIPID-PEROXIDATION | PROAPOPTOTIC BAX | glaucoma | DBA/2J MOUSE | INTRAOCULAR-PRESSURE | PROTECTS | RETINAL GANGLION-CELLS | IN-VITRO | OPHTHALMOLOGY | excitotoxicity | TRANSCRIPTION FACTOR | oxidative stress | MOLECULAR-MECHANISMS | Heme Oxygenase-1 - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Retinal Degeneration - metabolism | Retinal Degeneration - prevention & control | Retinal Ganglion Cells - pathology | Glial Fibrillary Acidic Protein | Ubiquinone - therapeutic use | bcl-Associated Death Protein - metabolism | Female | Mice, Inbred DBA | Membrane Proteins - metabolism | Glaucoma - metabolism | Real-Time Polymerase Chain Reaction | Superoxide Dismutase - metabolism | Disease Models, Animal | In Situ Nick-End Labeling | Ubiquinone - administration & dosage | Ubiquinone - analogs & derivatives | Axons - drug effects | Glaucoma - drug therapy | Mitochondria - metabolism | Mitochondria - drug effects | Vitamins - therapeutic use | Blotting, Western | Nerve Tissue Proteins - metabolism | Animals | Axons - pathology | Glutamic Acid - metabolism | Mice | Oxidative Stress - drug effects | Retinal Degeneration - pathology | Retinal Ganglion Cells - drug effects | Vitamins - administration & dosage
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1246 - 1261
Journal Article
Experimental Eye Research, ISSN 0014-4835, 05/2014, Volume 122, pp. 40 - 49
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 13, pp. 5473 - 5480
PURPOSE. To determine if bone marrow-derived stem cell (BMSC) small extracellular vesicles (sEV) promote retinal ganglion cell (RGC) neuroprotection in the... 
Glaucoma | Extracellular vesicles | Retinal ganglion cells | Exosomes | DBA/2J | Mesenchymal stem cells | SURVIVAL | FUNCTIONAL RECOVERY | POPULATION | extracellular vesicles | glaucoma | RNA-BINDING PROTEIN | RETINAL GANGLION-CELLS | INNER RETINA | mesenchymal stem cells | exosomes | ANIMAL-MODELS | OPHTHALMOLOGY | retinal ganglion cells | MICE | DYSFUNCTION
Journal Article