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Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 2, pp. 616 - 630.e6
Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite... 
CRISPR genome-wide screening | DDR | iPSC | PAWR | PMAIP1 | human pluripotent stem cells | hESC | APOPTOSIS | CONTRACTILITY | PATHWAY | EMBRYONIC STEM-CELLS | COPY NUMBER | TRANSCRIPTION | PROLIFERATION | GENERATION | DIFFERENTIATION | PAR-4 | CELL BIOLOGY
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Journal Article
European Urology, ISSN 0302-2838, 05/2018, Volume 73, Issue 5, pp. 751 - 759
Chemotherapy may exert immunomodulatory effects, thereby combining favorably with the immune checkpoint blockade. The pharmacodynamic effects of such... 
Urothelial cancer | Chemotherapy | DDR | Gemcitabine | DNA damage response | Immunotherapy | CTLA-4 | Metastatic | Cisplatin | CTLA-4 BLOCKADE | BLADDER-CANCER | IMMUNITY | MULTICENTER | SINGLE-ARM | CELL-DEATH | THERAPY | ERCC2 | UROLOGY & NEPHROLOGY | CARCINOMA | Carcinoma, Transitional Cell - mortality | Prognosis | Prospective Studies | Humans | Middle Aged | Male | Cisplatin - administration & dosage | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | DNA Mutational Analysis | Neoplasm Invasiveness - pathology | Aged, 80 and over | Female | Ipilimumab - administration & dosage | Molecular Targeted Therapy - methods | Carcinoma, Transitional Cell - genetics | DNA Damage - drug effects | Risk Assessment | Urologic Neoplasms - mortality | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Treatment Outcome | Mutation - genetics | Disease-Free Survival | Carcinoma, Transitional Cell - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Transitional Cell - drug therapy | Survival Analysis | Aged | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Care and treatment | Patient outcomes | DNA damage | Genes | Metastasis | DNA repair | Gene mutations | Analysis | DNA | Genetic aspects | Cancer | Index Medicus
Journal Article
Journal Article
生物学前沿:英文版, ISSN 1674-7984, 2017, Volume 12, Issue 1, pp. 49 - 62
BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disorder. It arises from a single point mutation in the LMNA gene.... 
Biochemistry, general | Life Sciences | Genetics and Population Dynamics | DDR | HGPS | Neurobiology | Proteomics | DSB repair | Developmental Biology | Cell Biology | Anopheles | Gene mutations | Progeria | Genes | Genomics | Physiological aspects | Genomes | Gene expression | Cells | Signal transduction | Mutation | Gene regulation | Genomic instability
Journal Article
EBioMedicine, ISSN 2352-3964, 03/2019, Volume 41, pp. 185 - 199
DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR... 
DNA damage repair | Glioma microenvironment | Midkine | Microglia | p53 | MEDICINE, RESEARCH & EXPERIMENTAL | TERT PROMOTER | CELL-LINES | CANCER | TEMOZOLOMIDE | TARGETS | HOMOLOGOUS RECOMBINATION | GROWTH-FACTOR | MUTATIONS | REVEALS
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 5, pp. 2917 - 2927
Journal Article
The Journal of Pathology, ISSN 0022-3417, 10/2018, Volume 246, Issue 2, pp. 134 - 140
Journal Article