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Molecular Cell, ISSN 1097-2765, 2008, Volume 29, Issue 2, pp. 169 - 179
The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by... 
RNA | MOLIMMUNO | RESPONSES | HELICASE LGP2 | VIRUS | ACID | REPLICATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIVIRAL INNATE IMMUNITY | HOST | IDENTIFICATION | ADAPTER PROTEIN | CELL BIOLOGY | RNA Caps - immunology | RNA Helicases - metabolism | Zinc - metabolism | Humans | rab GTP-Binding Proteins - genetics | Structure-Activity Relationship | RNA Helicases - chemistry | Interferons - immunology | RNA Caps - metabolism | Zinc - chemistry | Adenosine Triphosphatases - immunology | Interferon-Induced Helicase, IFIH1 | RNA, Viral - genetics | Immunity, Innate - physiology | RNA Caps - chemistry | Zinc - immunology | RNA Helicases - genetics | RNA, Viral - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Dimerization | RNA Caps - genetics | rab GTP-Binding Proteins - metabolism | Cell Line | DEAD Box Protein 58 | Adenosine Triphosphatases - metabolism | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Substrate Specificity - genetics | Polyphosphates - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Viral - chemistry | Polyphosphates - immunology | rab GTP-Binding Proteins - immunology | DEAD-box RNA Helicases - immunology | Interferons - metabolism | Adenosine Triphosphatases - chemistry | RNA, Viral - immunology | rab GTP-Binding Proteins - chemistry | Adenosine Triphosphatases - genetics | Structural Homology, Protein | RNA Helicases - immunology | Polyphosphates - chemistry | Sensors | G proteins | Biological response modifiers | Adenosine triphosphatase | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 4, pp. 1512 - 1517
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15181 - 15186
Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in plasmacytoid dendritic cells (pDCs). Previous studies suggest the... 
RNA | Dendritic cells | DNA | Cell lines | Antivirals | Antibodies | Small interfering RNA | Innate immunity | Cellular immunity | Sensors | Cytosolic sensor | VIRUS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | CYTOSOLIC DNA | ALPHA | INDUCTION | cytosolic sensor | innate immunity | PATHWAY | INFECTION | ADAPTER PROTEIN | RNA, Small Interfering - genetics | Dendritic Cells - immunology | Humans | Neoplasm Proteins - antagonists & inhibitors | Phylogeny | Neoplasm Proteins - metabolism | DEAD-box RNA Helicases - antagonists & inhibitors | Base Sequence | B-Lymphocytes - virology | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Neoplasm Proteins - genetics | Binding Sites | DEAD-box RNA Helicases - chemistry | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B p50 Subunit - metabolism | Signal Transduction | DNA, Viral - metabolism | Neoplasm Proteins - chemistry | Immunity, Innate | Interferon Regulatory Factor-7 - metabolism | Receptors, Transferrin - metabolism | DEAD-box RNA Helicases - genetics | B-Lymphocytes - immunology | CpG Islands | Myeloid Differentiation Factor 88 - metabolism | Natural immunity | Genetic aspects | Research | Biological response modifiers | Properties | Binding proteins | Human immunogenetics | Phosphates | Amino acids | Cytokines | Ribonucleic acid--RNA | Neurons | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
The Plant Journal, ISSN 0960-7412, 10/2013, Volume 76, Issue 1, pp. 115 - 127
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 31, Issue 1, pp. 25 - 34
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2011, Volume 12, Issue 2, pp. 137 - 143
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7648, pp. 115 - 119
Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene regulation and genome evolution in diverse ways(1). More than half... 
CELLS | COMPLEX | REPETITIVE ELEMENTS | CIRCULAR RNAS | DOSAGE COMPENSATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | CROSS-LINKING | SEQUENCING DATA | IDENTIFICATION | WEB SERVER | RNA-Binding Proteins - genetics | Adenosine Deaminase - chemistry | Protein Biosynthesis | Adenosine Deaminase - metabolism | RNA Editing - genetics | Humans | Male | Neoplasm Proteins - metabolism | Protein Isoforms - isolation & purification | RNA-Binding Proteins - isolation & purification | RNA - genetics | Adenosine Deaminase - isolation & purification | Protein Isoforms - metabolism | Protein Isoforms - chemistry | DEAD-box RNA Helicases - deficiency | HEK293 Cells | Transcription, Genetic | RNA, Double-Stranded - metabolism | Adenosine Deaminase - deficiency | DEAD-box RNA Helicases - metabolism | Neoplasm Proteins - genetics | Nucleic Acid Conformation | Alu Elements - genetics | RNA, Double-Stranded - chemistry | RNA - metabolism | Inverted Repeat Sequences - genetics | Cell Line | Adenosine Deaminase - genetics | RNA-Binding Proteins - chemistry | Gene Expression Regulation | Mutagenesis - genetics | Exons - genetics | Genes, Reporter - genetics | RNA - chemistry | Genome, Human - genetics | DEAD-box RNA Helicases - genetics | RNA - biosynthesis | Animals | RNA, Double-Stranded - genetics | Protein Binding | Mice | Neoplasm Proteins - deficiency | RNA-Binding Proteins - metabolism | Evolution, Molecular | Protein Isoforms - genetics | Genetic research | Research | RNA | Human genome | Genomics | Methods | Proteins | Amino acids | Genomes | Stem cells | Index Medicus
Journal Article