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by Tu, YF and Wu, XF and Yu, FY and Dang, JZ and Wang, J and Wei, YX and Cai, ZT and Zhou, ZP and Liao, WL and Li, L and Zhang, Y
BMC IMMUNOLOGY, ISSN 1471-2172, 05/2019, Volume 20, Issue 1, pp. 13 - 13
Journal Article
BMC MOLECULAR AND CELL BIOLOGY, ISSN 2661-8850, 06/2019, Volume 20, Issue 1, pp. 18 - 18
The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the... 
PAN2 | DEADENYLATION | DATABASE | MECHANISM | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDRUG | SEQUENCE | CLASSIFICATION | REVEALS | CELL BIOLOGY
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 1 - 14
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression principally via shortening of poly(A) tails of messenger RNA or... 
MESSENGER-RNA DEADENYLATION | CAF1 PROTEINS | RECRUITMENT | COMPLEX | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PURIFICATION | DROSOPHILA | SUBUNIT | NUCLEASE | Proteins | Poly(A) | Modules | mRNA | Gene expression | Ribonucleic acid--RNA | Protein interaction | Recombinant | Complexity
Journal Article
RNA Biology, ISSN 1547-6286, 09/2019, Volume 16, Issue 9, pp. 1147 - 1155
Evidence from yeast and mammals argues the existence of cross-talk between transcription and mRNA decay. Stabilization of transcripts upon depletion of mRNA... 
coupling | transcription | regulation | human cells | translation | cancer | Gene expression | mRNA decay | BIOCHEMISTRY & MOLECULAR BIOLOGY | RPB4P | DEADENYLATION | GENE-EXPRESSION | DEGRADATION | POLYMERASE-II | SUBUNIT | Index Medicus
Journal Article
ELIFE, ISSN 2050-084X, 08/2019, Volume 8
In the Caenorhabditis elegans germline, fem-3 Binding Factor (FBF) partners with LST-1 to maintain stem cells. A crystal structure of an FBF-2/LST-1/RNA... 
GERMLINE STEM-CELLS | RECRUITMENT | PUF PROTEIN | DEADENYLATION | WIDE IDENTIFICATION | SEQUENCE | BIOLOGY | ASH1 MESSENGER-RNA | BINDING PROTEIN | PUMILIO | DROSOPHILA | Proteins | Yeast | Site selection | Stem cells | Ribonucleic acid--RNA | Localization | Kinases | Protein structure | Crystal structure | Index Medicus
Journal Article
RNA, ISSN 1355-8382, 08/2019, Volume 25, Issue 8, pp. 975 - 984
The 3' end of the similar to 7 kb lncRNA MALAT1 contains an evolutionarily and structurally conserved element for nuclear expression (ENE) which confers... 
RNA dynamics | MOLECULAR-DYNAMICS | lncRNA | LONG NONCODING RNAS | MECHANISM | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RIBOSWITCH | molecular dynamics | ELEMENT | THERMODYNAMICS | DEADENYLATION | KINETICS | small angle X-ray scattering | ENE | X-ray scattering | Transcription | Base pairs | Conformation
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 515, Issue 3, pp. 403 - 409
Dengue virus (DENV) infection is a public health problem worldwide. To establish infection in host cells, DENV require host cellular mechanism to suppress and... 
IFN | ISGs | Dengue virus | CNOT2 | JAK-STAT pathway | DEADENYLATION | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CCR4-NOT COMPLEX | MESSENGER-RNA DECAY | Virus diseases | Antiviral agents | RNA | Analysis | Dengue viruses | Genetic research | Protein biosynthesis | Health aspects
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 07/2019, Volume 39, Issue 13
Tristetraprolin (TTP) is an anti-inflammatory protein that modulates the stability of certain cytokine/chemokine mRNAs. After initial high-affinity binding to... 
RECRUITMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | CCR4-NOT DEADENYLASE COMPLEX | BONE HOMEOSTASIS | FAMILY | CELL BIOLOGY | MESSENGER-RNA DEADENYLATION | PALINDROMIC RHEUMATISM | TTP | REGULATOR | AU-rich regions | inflammation | AU-RICH ELEMENTS | CCR4/NOT | deadenylation | tristetraprolin | RNA binding proteins
Journal Article
GENOME RESEARCH, ISSN 1088-9051, 07/2019, Volume 29, Issue 7, pp. 1100 - 1114
Posttranscriptional regulation plays a crucial role in shaping gene expression. During the maternal-to-zygotic transition (MZT), thousands of maternal... 
CLEARANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOUND PROTEOME | BINDING PROTEIN | TRANSLATION | IDENTIFICATION | MICRORNA TARGET SITES | DROSOPHILA | CODON OPTIMALITY | DEADENYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | REVEALS
Journal Article
Wiley Interdisciplinary Reviews: RNA, ISSN 1757-7004, 07/2019, Volume 10, Issue 4, pp. e1531 - n/a
Journal Article
Journal Article
Wiley Interdisciplinary Reviews: RNA, ISSN 1757-7004, 2019, pp. e1557 - e1557
Post-transcriptional regulation of gene expression is largely achieved at the level of splicing in the nucleus, and translation and mRNA decay in the cytosol.... 
3′-5′ decay | 5′-3′ decay | alternative splicing | RNA processing | deadenylation | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Current Opinion in Systems Biology, ISSN 2452-3100, 06/2019, Volume 15, pp. 48 - 57
An appropriate equilibrium between transcription and mRNA decay is vital for the function of the cell. The RNA-binding complexes regulating mRNA degradation,... 
Deadenylation | Computational modelling | PUF3 | CCR4-NOT | Multiomics | mRNA decay | RNA binding proteins
Journal Article
by Yan, ZP and Zeng, N and Wu, D and Ni, GX
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 06/2019, Volume 46, Issue 6, pp. 545 - 554
Poly(A) binding protein (PABP) family is commonly considered a protective barrier for the mRNA poly(A) tail. As a member of PABP family, cytoplasmic poly(A)... 
poly(A) binding protein (PABP) | DOMAIN | RECOGNITION | CYTOPLASMIC POLY(A)-BINDING PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | mRNA | MECHANISMS | DEADENYLATION | BIOPHYSICS | MESSENGER-RNA | GENE | GW182 PROTEINS | INTERACTS | TRANSLATIONAL CONTROL ELEMENT | PABPC1
Journal Article
Wiley Interdisciplinary Reviews: RNA, ISSN 1757-7004, 05/2019, Volume 10, Issue 3, pp. e1524 - n/a
In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their... 
stress granules | translation | P‐body | stress | phase separation | PROTEIN | PHASE-TRANSITIONS | GENE ONTOLOGY | CELL BIOLOGY | MESSENGER-RNA DEADENYLATION | TIA-1 | P-BODIES | P-body | INHIBITION | DYNAMICS | BODY | Proteins | Post-transcription | Translation | Cell survival | RNA transport | Gene regulation | Environmental changes | Granules | Gene expression | Protein transport | Localization | Cytoplasm
Journal Article