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The journal of clinical endocrinology and metabolism, ISSN 1945-7197, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
...). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Index Medicus | Abridged Index Medicus | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 01/2014, Volume 39, Issue 2, pp. 464 - 476
Journal Article
Ukrainian biochemical journal, ISSN 2409-4943, 01/2019, Volume 91, Issue 1, pp. 21 - 29
.... In this study, we examined whether expression levels of SIRT1 and SIRT2 were the key for the development of brain dysfunctions and whether PARP-1 inhibitors could affect the expression... 
is complex. In this study | 1.5-isoquinolinediol (ISO) | diabetes mellitus | PARP-1 inhibitors | respectively) for 2 weeks. The rats with blood glucose levels over 19.7 ± 2.1 mmol/l were taken into experiments. Western blots were performed to evaluate effects of PAPR-1 inhibitors on the levels of sirtuins | SIRT1 | one of the serious complications of diabetes mellitus | SIRT2 | expression of sirtuins | the ratio of free NAD/NADH couples decreased 3.1-fold compared to non-diabetic control. The administration of ISO increased only slightly the ratio of free NAD/NADH couples in the brain of diabetic rats while NAm increased this parameter 1.7-fold compared to diabetic rats. Therefore | while ISO didn’t affect expression of both sirtuins in diabetic rats. Furthermore | it was observed that in brain of diabetic rats | nicotinamide (NAm) | SIRT1 and SIRT2 expression. Diabetes induced significant reduction of SIRT1 expression and SIRT2 overexpression in brain nuclear extracts of diabetic rats compared to non-diabetic control. In brain | NAm attenuated SIRT2 overexpression in nuclear extracts of diabetic rats and slightly elevated SIRT1 expression | 1.5-isoquinolinediol (ISO) or nicotinamide (NAm) (3 or 100 mg/kg/daily i.p | we examined whether expression levels of SIRT1 and SIRT2 were the key for the development of brain dysfunctions and whether PARP-1 inhibitors could affect the expression of these proteins for prevention the development of DE in rats with type 1 diabetes. After 10 weeks of the streptozotocin-induced diabetes mellitus (70 mg/kg) | Wistar male rats were treated by i.p. injection with PARP-1 inhibitors
Journal Article
Indian journal of surgical oncology, ISSN 0975-7651, 12/2015, Volume 6, Issue 4, pp. 378 - 383
.... The aim of present study was to characterize the implication of BRCA2 expression in cases of non − hereditary (sporadic) breast cancer... 
Medicine & Public Health | Triple Negative Breast Cancer (TNBC) | Surgery | BRCA2 decreased expression | Oncology | Homology-directed Recombination (HR) | Double Strand Break (DSB) | Surgical Oncology | Original
Journal Article
Osteoarthritis and cartilage, ISSN 1063-4584, 2016, Volume 25, Issue 4, pp. 533 - 543
Journal Article
Journal Article