Nature Genetics, ISSN 1061-4036, 10/2013, Volume 45, Issue 10, pp. 1141 - 1149
Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a computational platform that integrates the analysis of copy number...
DELTA-CATENIN | GENETICS & HEREDITY | RECEPTOR | BCOR | DIFFERENTIATION | UBIQUITIN LIGASE HUWE1 | ADAPTER PROTEIN | CANCER | HIGH-GRADE GLIOMA | SOMATIC MUTATIONS | BRAIN-TUMORS | Receptor, Epidermal Growth Factor - genetics | Glioblastoma - genetics | Genomics | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Mutation | Transcription Factors - genetics | Catenins - genetics | Ligases | Stem cells | Physiological aspects | Genetic aspects | Research | Glioblastoma multiforme | Risk factors | Medical research | Nominations | Kinases | Genes
DELTA-CATENIN | GENETICS & HEREDITY | RECEPTOR | BCOR | DIFFERENTIATION | UBIQUITIN LIGASE HUWE1 | ADAPTER PROTEIN | CANCER | HIGH-GRADE GLIOMA | SOMATIC MUTATIONS | BRAIN-TUMORS | Receptor, Epidermal Growth Factor - genetics | Glioblastoma - genetics | Genomics | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Mutation | Transcription Factors - genetics | Catenins - genetics | Ligases | Stem cells | Physiological aspects | Genetic aspects | Research | Glioblastoma multiforme | Risk factors | Medical research | Nominations | Kinases | Genes
Journal Article
Oncotarget, ISSN 1949-2553, 05/2018, Volume 9, Issue 36, p. 24428
The mechanism of prostate cancer (PCa) progression towards the hormone refractory state remains poorly understood. Treatment options for such patients are...
Journal Article
Nature Protocols, ISSN 1754-2189, 09/2012, Volume 7, Issue 9, pp. 1741 - 1754
The ability to culture and maintain postnatal mouse hippocampal and cortical neurons is highly advantageous, particularly for studies on genetically engineered...
DELTA-CATENIN | DENSITY | MORPHOGENESIS | LOCALIZATION | SPINE | BIOCHEMICAL RESEARCH METHODS | DISPERSED CELL-CULTURE | SYNAPSE FORMATION | BETA-CATENIN | Animals, Newborn | Animals | Neurons - cytology | Mice | Hippocampus - cytology | Pyramidal Tracts - cytology | Cell Culture Techniques - methods | Cerebral Cortex - cytology | Physiological aspects | Hippocampus (Brain) | Research | Neurons
DELTA-CATENIN | DENSITY | MORPHOGENESIS | LOCALIZATION | SPINE | BIOCHEMICAL RESEARCH METHODS | DISPERSED CELL-CULTURE | SYNAPSE FORMATION | BETA-CATENIN | Animals, Newborn | Animals | Neurons - cytology | Mice | Hippocampus - cytology | Pyramidal Tracts - cytology | Cell Culture Techniques - methods | Cerebral Cortex - cytology | Physiological aspects | Hippocampus (Brain) | Research | Neurons
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 09/2014, Volume 34, Issue 36, pp. 12168 - 12181
During brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial...
14-3-3 | MIGRATION | LOCALIZATION | COMPLEX | delta-catenin | 14-3-3 PROTEINS | DENDRITIC MORPHOGENESIS | SPINDLE ORIENTATION | PROLIFERATION | IDENTIFICATION | NEUROSCIENCES | neuronal differentiation | BROMODEOXYURIDINE | neuronal migration | neurogenesis | LIS1
14-3-3 | MIGRATION | LOCALIZATION | COMPLEX | delta-catenin | 14-3-3 PROTEINS | DENDRITIC MORPHOGENESIS | SPINDLE ORIENTATION | PROLIFERATION | IDENTIFICATION | NEUROSCIENCES | neuronal differentiation | BROMODEOXYURIDINE | neuronal migration | neurogenesis | LIS1
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 01/2016, Volume 17, Issue 1, pp. 55 - 64
beta-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins...
ETS TRANSCRIPTION FACTORS | RNA-POLYMERASE-II | DELTA-CATENIN | ALPHA-CATENIN | P120 CATENIN | E-CADHERIN | CELL-CELL ADHESION | WNT-SIGNALING PATHWAY | NF-KAPPA-B | DESMOSOMAL ADHESION | CELL BIOLOGY | Animals | Cell Nucleus - metabolism | Signal Transduction | Models, Biological | Humans | Armadillo Domain Proteins - metabolism | Armadillo Domain Proteins - chemistry | beta Catenin - chemistry | Wnt Proteins - metabolism | beta Catenin - metabolism
ETS TRANSCRIPTION FACTORS | RNA-POLYMERASE-II | DELTA-CATENIN | ALPHA-CATENIN | P120 CATENIN | E-CADHERIN | CELL-CELL ADHESION | WNT-SIGNALING PATHWAY | NF-KAPPA-B | DESMOSOMAL ADHESION | CELL BIOLOGY | Animals | Cell Nucleus - metabolism | Signal Transduction | Models, Biological | Humans | Armadillo Domain Proteins - metabolism | Armadillo Domain Proteins - chemistry | beta Catenin - chemistry | Wnt Proteins - metabolism | beta Catenin - metabolism
Journal Article
Experimental Neurology, ISSN 0014-4886, 08/2019, Volume 318, pp. 22 - 31
δ-Catenin is abundant in the brain and affects its synaptic plasticity. Furthermore, loss of δ-catenin is related to the deficits of learning and memory,...
δ-Catenin | Glutamate receptor | Sociability | Anxiety | N-cadherin | Memory | PHOSPHORYLATION | CTNND2 | delta-Catenin | BETA-CATENIN | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | DELETION | MORPHOGENESIS | GENE | MOUSE MODEL | ARMADILLO PROTEIN
δ-Catenin | Glutamate receptor | Sociability | Anxiety | N-cadherin | Memory | PHOSPHORYLATION | CTNND2 | delta-Catenin | BETA-CATENIN | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | DELETION | MORPHOGENESIS | GENE | MOUSE MODEL | ARMADILLO PROTEIN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 29, pp. 11625 - 11638
Neural wiring and activity are essential for proper brain function and behavioral outputs and rely on mechanisms that guide the formation, elimination, and...
DELTA-CATENIN | CELLS | LOCALIZATION | catenin | REPEAT PROTEIN/DELTA-CATENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | neuron | ACIDIFICATION | dendritic spine | neural development | HIPPOCAMPAL-NEURONS | FAMILY | calpain | SYNAPSE MORPHOGENESIS | proteolysis | PLASTICITY
DELTA-CATENIN | CELLS | LOCALIZATION | catenin | REPEAT PROTEIN/DELTA-CATENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | neuron | ACIDIFICATION | dendritic spine | neural development | HIPPOCAMPAL-NEURONS | FAMILY | calpain | SYNAPSE MORPHOGENESIS | proteolysis | PLASTICITY
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2008, Volume 83, Issue 4, pp. 504 - 510
Schizophrenia is a severe psychiatric disease with complex etiology, affecting approximately 1% of the general population. Most genetics studies so far have...
NEURONAL MIGRATION | DELTA-CATENIN | SNP GENOTYPING DATA | MENTAL-RETARDATION | COPY-NUMBER | HIDDEN-MARKOV MODEL | DU-CHAT SYNDROME | STRUCTURAL VARIANTS | GENETICS & HEREDITY | AUTISM SPECTRUM DISORDER | GENOME | Recurrence | Genetic Predisposition to Disease | Oligonucleotide Array Sequence Analysis | Exons | Humans | Male | Genetic Variation | Schizophrenia - genetics | Adolescent | Adult | Female | Models, Genetic | Neurons - metabolism | Polymorphism, Single Nucleotide | Cohort Studies | Schizophrenia | Genetic aspects | Research | Human genome | Gene expression | Analysis | Report
NEURONAL MIGRATION | DELTA-CATENIN | SNP GENOTYPING DATA | MENTAL-RETARDATION | COPY-NUMBER | HIDDEN-MARKOV MODEL | DU-CHAT SYNDROME | STRUCTURAL VARIANTS | GENETICS & HEREDITY | AUTISM SPECTRUM DISORDER | GENOME | Recurrence | Genetic Predisposition to Disease | Oligonucleotide Array Sequence Analysis | Exons | Humans | Male | Genetic Variation | Schizophrenia - genetics | Adolescent | Adult | Female | Models, Genetic | Neurons - metabolism | Polymorphism, Single Nucleotide | Cohort Studies | Schizophrenia | Genetic aspects | Research | Human genome | Gene expression | Analysis | Report
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2008, Volume 31, Issue 9, pp. 487 - 494
Synapse formation involves reciprocal interactions between cells resulting in formation of a structure optimized for efficient information transfer. Recent...
Neurology | DELTA-CATENIN | MEDIATED ADHESION | NERVOUS-SYSTEM | CELL-CELL CONTACTS | REPEAT PROTEIN/DELTA-CATENIN | ALPHA-CATENIN | P120 CATENIN | BETA-CATENIN | NEUROSCIENCES | REGULATES DENDRITIC SPINE | N-CADHERIN | Adaptation, Physiological | Central Nervous System - physiology | Animals | Neuronal Plasticity - physiology | Central Nervous System - cytology | Cell Adhesion - physiology | Synapses - physiology | Humans | Neurons - physiology | Cadherins - physiology | Catenins - physiology | Neuroplasticity | Cell adhesion | Influence | Research | Properties | Synapses | Membrane proteins
Neurology | DELTA-CATENIN | MEDIATED ADHESION | NERVOUS-SYSTEM | CELL-CELL CONTACTS | REPEAT PROTEIN/DELTA-CATENIN | ALPHA-CATENIN | P120 CATENIN | BETA-CATENIN | NEUROSCIENCES | REGULATES DENDRITIC SPINE | N-CADHERIN | Adaptation, Physiological | Central Nervous System - physiology | Animals | Neuronal Plasticity - physiology | Central Nervous System - cytology | Cell Adhesion - physiology | Synapses - physiology | Humans | Neurons - physiology | Cadherins - physiology | Catenins - physiology | Neuroplasticity | Cell adhesion | Influence | Research | Properties | Synapses | Membrane proteins
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2013, Volume 45, Issue 10, pp. 1105 - 1107
Identifying genomic alterations in cancer does not guarantee therapeutic benefit. A new study combining DNA and RNA sequencing with functional validation...
DELTA-CATENIN | SURVIVAL | CELLS | GENETICS & HEREDITY | EXPRESSION | CANCER | PROGRESSION | Brain Neoplasms - genetics | Glioblastoma - genetics | Genomics | Humans | Genetic aspects | Diagnosis | Research | Glioblastoma multiforme | Risk factors | Mutation | Genes | Tumors
DELTA-CATENIN | SURVIVAL | CELLS | GENETICS & HEREDITY | EXPRESSION | CANCER | PROGRESSION | Brain Neoplasms - genetics | Glioblastoma - genetics | Genomics | Humans | Genetic aspects | Diagnosis | Research | Glioblastoma multiforme | Risk factors | Mutation | Genes | Tumors
Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 12/2012, Volume 169, Issue 12, pp. 1309 - 1317
ObjectiveMultiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first...
DELTA-CATENIN | COMMON VARIANTS | MENTAL-RETARDATION | GENOTYPE | PSYCHIATRY | RISK | CLASSIFICATION | PHENOTYPES | MUTATIONS | HAPLOTYPE | FEATURES | Multifactorial Inheritance - genetics | Genome-Wide Association Study | Psychiatric Status Rating Scales | Schizophrenia - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Female | Male | Factor Analysis, Statistical | Schizophrenic Psychology | Case-Control Studies | Linkage Disequilibrium | Schizophrenia | Genome-wide association studies | Genetic aspects | Genetic variation
DELTA-CATENIN | COMMON VARIANTS | MENTAL-RETARDATION | GENOTYPE | PSYCHIATRY | RISK | CLASSIFICATION | PHENOTYPES | MUTATIONS | HAPLOTYPE | FEATURES | Multifactorial Inheritance - genetics | Genome-Wide Association Study | Psychiatric Status Rating Scales | Schizophrenia - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Female | Male | Factor Analysis, Statistical | Schizophrenic Psychology | Case-Control Studies | Linkage Disequilibrium | Schizophrenia | Genome-wide association studies | Genetic aspects | Genetic variation
Journal Article