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Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 01/2003, Volume 50, Issue 1, pp. 5 - 25
The aim of the current study is to investigate whether homology models of G‐Protein‐Coupled Receptors (GPCRs) that are based on bovine rhodopsin are reliable... 
docking | scoring | homology modeling | GPCRs | structure‐based ligand design | Docking | Scoring | Structure-based ligand design | Homology modeling | BETA ADRENERGIC-RECEPTOR | AGONIST ACTIVATION | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-based ligand design | MUSCARINIC RECEPTOR | DELTA-OPIOID RECEPTOR | INDUCED CONFORMATIONAL-CHANGES | TRANSMEMBRANE REGIONS | BIOPHYSICS | SCORING FUNCTIONS | 3-DIMENSIONAL MODELS | BETA-ADRENERGIC RECEPTOR | Humans | Molecular Sequence Data | Heterotrimeric GTP-Binding Proteins - metabolism | Adrenergic beta-2 Receptor Agonists | Receptors, Cell Surface - antagonists & inhibitors | Drug Delivery Systems | Receptors, Adrenergic, beta-2 - chemistry | Receptors, Vasopressin - chemistry | Cattle | Computer Simulation | Receptors, Dopamine D2 - chemistry | Receptors, Cell Surface - chemistry | Databases, Factual | Rhodopsin - chemistry | Amino Acid Sequence | Computational Biology - methods | Receptors, Opioid, delta - chemistry | Receptors, Dopamine D2 - agonists | Receptors, Cell Surface - agonists | Models, Molecular | Receptor, Muscarinic M1 | Receptors, Muscarinic - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Algorithms | Animals | Receptors, Dopamine D3 | Ligands | Antidiuretic Hormone Receptor Antagonists | Dopamine D2 Receptor Antagonists | Receptors, Opioid, delta - agonists | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | Index Medicus | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2012, Volume 166, Issue 4, pp. 1444 - 1460
BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non‐psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the... 
ileum | TRPA1 | 2‐arachydonoylglycerol | intestinal motility | cannabinoids | cannabichromene | cannabinoid receptors | anandamide | transient receptor potential (TRP) channels | gastrointestinal transit | 2-arachydonoylglycerol | TRP CHANNELS | PIG SMALL-INTESTINE | BOWEL-DISEASE | MOUSE INTESTINE | DELTA-OPIOID-RECEPTOR | EXPERIMENTAL COLITIS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL MOTILITY | POTENTIAL ANKYRIN 1 | CB1 RECEPTORS | Transient Receptor Potential Channels - antagonists & inhibitors | Gastrointestinal Motility - drug effects | Ileum - metabolism | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Ileum - immunology | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Jejunum - metabolism | Jejunum - drug effects | Arachidonic Acids - metabolism | Cannabis - chemistry | Ileum - drug effects | Receptor, Cannabinoid, CB1 - agonists | Jejunum - physiopathology | Duodenum - metabolism | Ileitis - physiopathology | Duodenum - physiopathology | Ileitis - metabolism | Transient Receptor Potential Channels - metabolism | Endocannabinoids | Duodenum - immunology | Ileitis - drug therapy | Jejunum - immunology | Ethanolamines | Polyunsaturated Alkamides - metabolism | Transient Receptor Potential Channels - agonists | Mice, Inbred ICR | Gene Expression Regulation - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Gastrointestinal Agents - pharmacology | Animals | Receptor, Cannabinoid, CB1 - genetics | Ileitis - immunology | Muscle Contraction - drug effects | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | Ileum - physiopathology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Palmitic Acids - metabolism | Duodenum - drug effects | Glycerol | Rodents | Motility | Index Medicus | Research Papers
Journal Article