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Neuropharmacology, ISSN 0028-3908, 01/2009, Volume 56, Issue 1, pp. 182 - 189
Inhibition in the brain is dominated by the neurotransmitter γ-aminobutyric acid (GABA); operating through GABA receptors. This form of neural inhibition was... 
Thalamus | Allosteric modulator | Extrasynaptic | GABAA receptor | Delta subunit | GABA | receptor
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2011, Volume 31, Issue 50, pp. 18198 - 18210
The hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body's response to stress, is largely under GABAergic control. Here we demonstrate that... 
PARAVENTRICULAR NUCLEUS NEURONS | PARVOCELLULAR NEURONS | NEUROPATHIC PAIN | LAMINA-I NEURONS | DELTA-SUBUNIT | TEMPORAL-LOBE EPILEPSY | CATION-CHLORIDE COTRANSPORTERS | NEUROACTIVE STEROIDS | DOWN-REGULATION | ELECTROPHYSIOLOGICAL PROPERTIES | NEUROSCIENCES
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 12/2011, Volume 7, Issue 12, pp. 942 - 949
Lipidated Rho and Rab GTP-binding proteins are transported between membranes in complex with solubilizing factors called 'guanine nucleotide dissociation... 
DELTA-SUBUNIT | PDE-DELTA | STRUCTURAL BASIS | RHEB | PRENYL-BINDING PROTEIN | DISSOCIATION INHIBITOR | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | RAB GTPASES
Journal Article
SCIENCE, ISSN 0036-8075, 03/2010, Volume 327, Issue 5972, pp. 1515 - 1518
The onset of puberty defines a developmental stage when some learning processes are diminished, but the mechanism for this deficit remains unknown. We found... 
DELTA-SUBUNIT | WATER MAZE | INHIBITION | RAT | ANXIETY | MULTIDISCIPLINARY SCIENCES | SPATIAL MEMORY | LONG-TERM POTENTIATION | STRESS | MATURATION | HIPPOCAMPAL-NEURONS
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 10/2009, Volume 29, Issue 41, pp. 12757 - 12763
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated... 
DELTA-SUBUNIT | TEMPORAL-LOBE EPILEPSY | THALAMIC RELAY NEURONS | AMINOBUTYRIC ACID(A) RECEPTOR | NEUROACTIVE STEROIDS | RAT SOMATOSENSORY CORTEX | DENTATE GYRUS | NEUROSCIENCES | NEUROSTEROID MODULATION | CEREBELLAR GRANULE CELLS | TONIC GABAERGIC INHIBITION
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 56, Issue 5, pp. 763 - 770
Some GABA receptors (GABA Rs) are activated by low transmitter levels present in the extracellular space and generate an uninterrupted conductance referred to... 
DELTA-SUBUNIT | A RECEPTORS | NEUROTRANSMITTER TRANSPORTERS | RAT CEREBELLUM | ENHANCES COGNITION | HIPPOCAMPAL PYRAMIDAL NEURONS | DENTATE GYRUS | TONIC INHIBITION | MEDIATED CONDUCTANCE | NEUROSCIENCES | CEREBELLAR GRANULE CELLS
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6
Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest... 
ETOMIDATE | PIPER-METHYSTICUM | DELTA-SUBUNIT | IN-VITRO | INHIBITION | KAVALACTONES | ENRICHED EXTRACT | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | BRAIN | PROPOFOL
Journal Article
NATURE NEUROSCIENCE, ISSN 1097-6256, 04/2007, Volume 10, Issue 4, pp. 469 - 477
Puberty is characterized by mood swings and anxiety, which are often produced by stress. Here we show that THP ( allopregnanolone), a steroid that is released... 
DELTA-SUBUNIT | CHANNEL | STEROIDS | ALLOPREGNANOLONE LEVELS | PREMENSTRUAL-SYNDROME | RAT-BRAIN | DENTATE GYRUS | STRESS | TONIC INHIBITION | HIPPOCAMPAL-NEURONS | NEUROSCIENCES
Journal Article
NEUROSCIENCE, ISSN 0306-4522, 04/2013, Volume 236, pp. 345 - 372
The GABA(A) receptor is the main inhibitory receptor in the brain and its subunits originate from different genes or gene families (alpha 1-alpha 6, beta... 
TEMPORAL-LOBE EPILEPSY | mouse brain | KNOCKOUT MICE | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | ADULT-RAT BRAIN | HIPPOCAMPUS | DELTA-SUBUNIT | OLFACTORY-BULB | immunohistochemistry | ALTERED EXPRESSION | TONIC INHIBITION | IMMUNOCYTOCHEMICAL DISTRIBUTION | GABA(A) receptor subunits | in situ hybridization
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 01/2019, Volume 368, Issue 1, pp. 100 - 105
Central alpha 4 beta delta receptors are the most abundant isoform of delta subunit-containing extrasynaptic GABA(A) receptors that mediate tonic inhibition.... 
DELTA-SUBUNIT | INTRAVENOUS ANESTHETICS | SUBTYPES | SITES | TRANSMEMBRANE DOMAIN | ALPHA-1-BETA-3-DELTA | PHARMACOLOGY & PHARMACY | GAMMA-AMINOBUTYRIC-ACID | ALLOSTERIC MODULATION | TONIC INHIBITION | BINDING
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, ISSN 0005-2736, 07/2013, Volume 1828, Issue 7, pp. 1541 - 1549
Voltage-gated calcium channels consist of the main pore-forming alpha(1) subunit, together, except in the case of the T-type channels, with beta and... 
Auxiliary subunit | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIHYDROPYRIDINE RECEPTOR | Electrophysiology | TISSUE-SPECIFIC EXPRESSION | Calcium channel | SKELETAL-MUSCLE | NEUROPATHIC PAIN | TARGETED DISRUPTION | Alpha2delta | BIOPHYSICS | CA2+ CHANNEL | XENOPUS OOCYTES | GABAPENTIN-BINDING | ALPHA 2/DELTA SUBUNIT
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2004, Volume 101, Issue 10, pp. 3662 - 3667
The principal inhibitory neurotransmitter in the mammalian brain, gamma-aminobutyric acid (GABA), is thought to regulate memory processes by activating... 
MESSENGER-RNAS | DELTA-SUBUNIT | AMINO-ACID | GABAERGIC INHIBITION | GABA(A)-RECEPTOR SUBTYPES | MULTIDISCIPLINARY SCIENCES | RAT-BRAIN | LIGAND | CONTAINING GABA(A) RECEPTORS | MICE LACKING | CEREBELLAR GRANULE CELLS
Journal Article
Current Molecular Pharmacology, ISSN 1874-4672, 2013, Volume 6, Issue 1, pp. 44 - 49
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2010, Volume 13, Issue 4, pp. 431 - 438
Presynaptic GABA(A) receptors (GABA(A)Rs) occur at hippocampal mossy fiber synapses. Whether and how they modulate orthodromic signaling to postsynaptic... 
TRANSMITTER RELEASE | DELTA-SUBUNIT | PYRAMIDAL NEURONS | ACTIVATION | INHIBITION | GLUTAMATE RELEASE | RAT | DENTATE GYRUS | GRANULE CELLS | NEUROSCIENCES | MODULATION
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 01/2016, Volume 356, Issue 1, pp. 148 - 156
Ethanol produces changes in GABA(A) receptor trafficking and function that contribute to ethanol dependence symptomatology. Extrasynaptic gamma-aminobutyric... 
GAMMA | DELTA-SUBUNIT | MUTANT MICE | ALCOHOL | PHOSPHORYLATION | PHARMACOLOGY & PHARMACY | SUBUNIT EXPRESSION | TONIC INHIBITION | HIPPOCAMPAL-NEURONS | MICE LACKING | CONSUMPTION
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2009, Volume 14, Issue 17, pp. 866 - 875
Gamma-amino butyric acid (GABA) is the most abundant inhibitory neurotransmitter in the central nervous system (CNS) and many physiological actions are... 
DELTA-SUBUNIT | A RECEPTORS | ENHANCES COGNITION | ALPHA-5 SUBUNIT | NEUROACTIVE STEROIDS | INVERSE AGONIST | PHARMACOLOGY & PHARMACY | RAT-BRAIN | NEURONAL EXCITABILITY | TONIC INHIBITION | SUBUNIT-DEFICIENT MICE
Journal Article
Biophysical Journal, ISSN 0006-3495, 08/2019, Volume 117, Issue 3, pp. 587 - 601
The ring-shaped sliding clamp proteins have crucial roles in the regulation of DNA replication, recombination, and repair in all organisms. We previously... 
INTRINSIC STABILITY | MOLECULAR-DYNAMICS | DELTA-SUBUNIT | REPLICATION MACHINE | BIOPHYSICS | CELL NUCLEAR ANTIGEN | SLIDING-CLAMP | CRYSTAL-STRUCTURE | ESCHERICHIA-COLI | PROCESSIVITY FACTOR | POLYMERASE-III HOLOENZYME | Index Medicus
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2003, Volume 100, Issue 25, pp. 15218 - 15223
gamma-Aminobutyric acid type A receptors (GABARs) have long been implicated in mediating ethanol (EtOH) actions, but so far most of the reported recombinant... 
RECTIFYING POTASSIUM CHANNELS | DELTA-SUBUNIT | SUBUNIT KNOCKOUT MICE | GABA(A) RECEPTOR | POSTSYNAPTIC POTENTIALS | GABAERGIC TRANSMISSION | ION CURRENT | MULTIDISCIPLINARY SCIENCES | GENERAL-ANESTHETICS | GRANULE CELLS | HIPPOCAMPAL-NEURONS
Journal Article
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