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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 26, pp. 12011 - 12016
Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease (AD). The ApoE4 isoform significantly reduces the mean age-of-onset of... 
Protein isoforms | Brain | Receptors | Phosphorylation | Neurons | N methyl D aspartate receptors | Long term potentiation | Recycling | Alzheimers disease | Experimental procedures | Lipoprotein receptor | Reelin | NMDA receptor | Neurodegeneration | Alzheimer's disease | LIPOPROTEIN RECEPTORS | lipoprotein receptor | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | DISEASE | neurodegeneration | BETA | Receptors, Glutamate - metabolism | Apolipoprotein E4 - genetics | LDL-Receptor Related Proteins | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Receptors, Lipoprotein - metabolism | Brain - metabolism | Neuronal Plasticity - physiology | Cell Adhesion Molecules, Neuronal - metabolism | Extracellular Matrix Proteins - metabolism | Receptors, AMPA - metabolism | Recombinant Proteins - metabolism | Apolipoprotein E4 - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Mice, Transgenic | Recombinant Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Alzheimer Disease - metabolism | Long-Term Potentiation | Mice | Serine Endopeptidases - metabolism | Models, Neurological | Alzheimer Disease - genetics | In Vitro Techniques | Neuroplasticity | Methyl aspartate | Cell receptors | Physiological aspects | Research | Properties | Neurophysiology | Neurosciences | Lipoproteins | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 06/2009, Volume 50, Issue 6, pp. 1090 - 1100
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR-/-) or apolipoprotein E (apoE(-/-))... 
Cholesterol 7α-hydroxylase | Sterol 12 α-hydroxylase | Atherosclerosis | Small heterodimer partner | atherosclerosis | TRIGLYCERIDE LEVELS | TRANSGENIC EXPRESSION | NEGATIVE FEEDBACK-REGULATION | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID SYNTHESIS | ESTROGEN-RECEPTOR | DENSITY-LIPOPROTEIN CHOLESTEROL | cholesterol 7 alpha-hydroxylase | NONFASTING TRIGLYCERIDES | small heterodimer partner | E-DEFICIENT MICE | sterol 12 alpha-hydroxylase | Dyslipidemias - genetics | Apolipoproteins E - deficiency | Gene Expression - drug effects | Steroid 12-alpha-Hydroxylase - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - deficiency | Atherosclerosis - genetics | Male | Lipids - blood | Receptors, LDL - deficiency | Dyslipidemias - prevention & control | Female | Indoles - pharmacology | Receptors, LDL - genetics | Atherosclerosis - pathology | Mice, Inbred C57BL | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Atherosclerosis - metabolism | Mice, Knockout | Azepines - pharmacology | Cholesterol 7-alpha-Hydroxylase - genetics | Steroid 12-alpha-Hydroxylase - genetics | Animals | Apolipoproteins E - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Dyslipidemias - metabolism | Mice | Cholesterol 7-alpha-Hydroxylase - antagonists & inhibitors | Atherosclerosis - prevention & control | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | sterol 12 α-hydroxylase | cholesterol 7α-hydroxylase
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1505 - 1512
OBJECTIVE—Sphingosine 1-phosphate (S1P) partly accounts for antiatherogenic properties of high-density lipoproteins. We previously demonstrated that FTY720, a... 
Inflammation | High-density lipoproteins | T cells | Macrophage | Murine models of disease | Sphingosine 1-phosphate | CELLS | ACTIVATION | APOLIPOPROTEIN M | SPHINGOSINE-1-PHOSPHATE ANALOG | macrophage | high-density lipoproteins | DEFICIENT MICE | HYPERLIPIDEMIC MICE | murine models of disease | HIGH-DENSITY-LIPOPROTEIN | REDUCES ATHEROSCLEROSIS | inflammation | IMMUNE-RESPONSES | FTY720 | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate | HEMATOLOGY | Inflammation - pathology | Sulfhydryl Compounds - pharmacology | Atherosclerosis - genetics | Dendritic Cells - immunology | Humans | Aorta - metabolism | Aortic Diseases - metabolism | CD4-Positive T-Lymphocytes - immunology | Inflammation - metabolism | U937 Cells | Lipids - blood | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Dendritic Cells - drug effects | Receptors, Lysosphingolipid - metabolism | Macrophages - immunology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Aortic Diseases - immunology | Aorta - drug effects | Aorta - immunology | Inflammation - immunology | Biomarkers - blood | Atherosclerosis - metabolism | Cardiovascular Agents - pharmacology | Mice, Knockout | Aorta - pathology | Endothelial Cells - immunology | Aortic Diseases - genetics | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Inflammation - genetics | Receptors, Lysosphingolipid - agonists | Macrophages - drug effects | Inflammation - prevention & control | Lymphopenia - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Macrophage Activation - drug effects | Atherosclerosis - prevention & control | CD4-Positive T-Lymphocytes - drug effects | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2011, Volume 364, Issue 2, pp. 136 - 145
Journal Article
Circulation, ISSN 0009-7322, 06/2013, Volume 127, Issue 24, pp. 2403 - 2413
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2017, Volume 47, pp. 31 - 43
Abstract Introduction Endarterectomized human atherosclerotic plaques are a valuable basis for gene expression studies to disclose novel imaging biomarkers and... 
Radiology | ApoE KO | Shear stress | Cannabinoid receptor type 2 | Gene expression | Positron emission tomography | Plaque inflammation | MICE DEFICIENT | ENDOCANNABINOID SYSTEM | COSTIMULATORY MOLECULES | IN-VIVO | SHEAR-STRESS | MOUSE MODEL | BIOLOGICAL EVALUATION | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | DENSITY-LIPOPROTEIN RECEPTOR | Biomarkers - metabolism | Plaque, Atherosclerotic - diagnostic imaging | Radioactive Tracers | Plaque, Atherosclerotic - genetics | Plaque, Atherosclerotic - metabolism | Adamantane - metabolism | Humans | Gene Expression Regulation | Quinolones - metabolism | Male | Receptor, Cannabinoid, CB2 - genetics | Antigens, CD - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carotid Artery Diseases - diagnostic imaging | Antigens, Differentiation, Myelomonocytic - metabolism | Carotid Artery Diseases - genetics | Mice | Carotid Artery Diseases - metabolism | Adamantane - analogs & derivatives | Carbon Radioisotopes | Positron Emission Tomography Computed Tomography - methods | Genetic research | Genes | Atherosclerosis | PET imaging | Lymphocytes | Apolipoproteins | Target recognition | Addition polymerization | CD86 antigen | Emission analysis | Lymphocytes T | Matrix metalloproteinase | Arteries | Cell activation | Histopathology | Apolipoprotein E | Imaging | Tomography | Bioindicators | Metalloproteinase | Lesions | Plaques | Antigens | Positron emission | CD80 antigen | Inflammation | Cells | Polymerase chain reaction | Immune systems | Autoradiography | Arteriosclerosis | Biomarkers | Mechanical stimuli | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2010, Volume 327, Issue 5964, pp. 459 - 463
Wnt/ß-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal... 
Receptors | Phosphorylation | Blastomeres | Messenger RNA | HEK293 cells | Neurons | Genes | Small interfering RNA | Acidification | Reports | Embryos | CELLS | ACTIVATION | PROTEIN | RENIN | PATHWAY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ANGIOTENSIN-II | (PRO)RENIN RECEPTOR | BETA-CATENIN | LRP6 | LDL-Receptor Related Proteins - metabolism | Xenopus Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Wnt Proteins - metabolism | Central Nervous System - embryology | Vacuolar Proton-Translocating ATPases - metabolism | Xenopus - embryology | Gene Expression Regulation, Developmental | Body Patterning | Cell Line | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Frizzled Receptors - metabolism | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Xenopus - metabolism | Central Nervous System - cytology | Cell Line, Tumor | Wnt3 Protein | Xenopus Proteins - metabolism | Mice | RNA, Small Interfering | Hydrogen-Ion Concentration | Receptors, Cell Surface - genetics | Proteins | Signal transduction | Biochemistry | Cellular biology | Index Medicus
Journal Article