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Cellular and Molecular Life Sciences, ISSN 1420-682X, 04/2009, Volume 66, Issue 7, pp. 1163 - 1177
Protein kinase inhibitors represent an important and still emerging class of targeted therapeutic agents. Drug discovery and development strategies have... 
Life Sciences | Biochemistry, general | kinase inhibitor | Life Sciences, general | drug discovery | Protein kinase | kinase signaling | Biomedicine general | Cell Biology | Kinase signaling | Drug discovery | Kinase inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | PP60(C-SRC) TYROSINE KINASE | ORAL MEK INHIBITOR | PHASE-II | MONOCLONAL-ANTIBODY | ADVANCED COLORECTAL-CANCER | CELL BIOLOGY | CELL LUNG-CANCER | CYCLIN-DEPENDENT KINASES | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | ATP COMPETITIVE INHIBITORS | Protein Kinases - metabolism | Signal Transduction | Humans | Models, Molecular | Neoplasms - enzymology | Antibodies, Monoclonal - therapeutic use | Neoplasms - blood supply | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Protein Kinase Inhibitors - adverse effects | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Neoplasms - drug therapy | Protein Kinase Inhibitors - chemistry | Antineoplastic Agents - adverse effects | Protein Kinase Inhibitors - therapeutic use | Angiogenesis Inhibitors - therapeutic use | Molecular Structure | Angiogenesis Inhibitors - adverse effects | Angiogenesis Inhibitors - chemistry | Tyrosine | Care and treatment | Health aspects | Protein kinases | Biopharmaceutics | Cancer | Studies | Kinases | Drug therapy | Molecular biology | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1083 - 1097
Genetic variation at the chromosome 9p21 risk locus promotes cardiovascular disease; however, it is unclear how or which proteins encoded at this locus... 
ENDOTHELIAL LIPASE | MEDICINE, RESEARCH & EXPERIMENTAL | SEQUENCE VARIANT | CHOLESTEROL EFFLUX | SUSCEPTIBILITY | MUSCLE-CELL APOPTOSIS | CHROMOSOME 9P21 | ABC TRANSPORTERS | CORONARY-HEART-DISEASE | EXPRESSION | MOUSE MODELS | Plaque, Atherosclerotic - genetics | Atherosclerosis - genetics | Coculture Techniques | Humans | Male | Atherosclerosis - enzymology | Plaque, Atherosclerotic - enzymology | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Calreticulin - metabolism | Female | Plaque, Atherosclerotic - pathology | E2F4 Transcription Factor - metabolism | Macrophages - physiology | Atherosclerosis - pathology | Coronary Vessels - pathology | Gene Expression | Myocytes, Smooth Muscle - enzymology | Down-Regulation | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Cells, Cultured | Mice, Knockout | E2F4 Transcription Factor - genetics | Animals | Retinoblastoma Protein - genetics | Carotid Arteries - pathology | Mice | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Quantitative Trait Loci | Necrosis - enzymology | Phagocytosis | Apoptosis | Physiological aspects | Development and progression | Enzyme inhibitors | Genetic variation | Identification and classification | Atherosclerosis | Studies | Heart attacks | Cardiovascular disease | Software | Genomes | Grants | Kinases | Laboratory animals | Gene expression | Experiments
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2010, Volume 9, Issue 8, pp. 2344 - 2353
Journal Article
Journal Article