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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1818
Journal Article
Journal Article
Journal Article
CANCER BIOLOGY & THERAPY, ISSN 1538-4047, 05/2011, Volume 11, Issue 9, pp. 793 - 800
The antibody trastuzumab and the tyrosine kinase inhibitor lapatinib are approved by the FDA for the treatment of HER2-overexpressing breast cancer. These... 
ADJUVANT CHEMOTHERAPY | GROWTH-FACTOR-RECEPTOR | LAPATINIB RESISTANCE | lapatinib | MONOCLONAL-ANTIBODY | TRASTUZUMAB RESISTANCE | SOMATIC MUTATIONS | trastuzumab | tyrosine kinase inhibitors | CELL LUNG-CANCER | ONCOLOGY | HER2 (ERBB2) | METASTATIC BREAST-CANCER | DUAL PI3K/MTOR INHIBITOR | antibodies | drug resistance | DEPENDENT ACTIVATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8061 - 8077
Advances in the genetics, function, and stage-specificity of Plasmodium kinases has driven robust efforts to identify targets for the design of antimalarial... 
CYCLIC-AMP | CHEMISTRY, MEDICINAL | 5-AMINOPYRAZOLE-4-CARBOXAMIDE ANALOGS | ARTEMISININ RESISTANCE | C. PARVUM | STAGE-SPECIFIC EXPRESSION | SELECTIVE INHIBITORS | DEPENDENT PROTEIN-KINASE | FIKK KINASE | MALARIA PARASITES | POTENT INHIBITORS
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2006, Volume 12, Issue 9, pp. 1056 - 1064
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
The Plant Cell, ISSN 1040-4651, 7/2001, Volume 13, Issue 7, pp. 1653 - 1667
Cyclin-dependent kinase inhibitors, such as the mammalian p27 Kip1 protein, regulate correct cell cycle progression and the integration of developmental... 
Proteins | Leaves | Yeasts | Epidermal cells | Cell cycle | Cell division | Plants | Transgenic plants | Cyclins | Plant cells | FISSION YEAST | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED TRANSFORMATION | ROOT-GROWTH | P27(KIP1) | PLANT SCIENCES | CELL BIOLOGY | CDK INHIBITORS | THALIANA | PLANTS | CELL-CYCLE | EXPRESSION | Cyclin-Dependent Kinases - metabolism | Mitosis | Molecular Sequence Data | Calcium-Binding Proteins - antagonists & inhibitors | Sequence Homology | Arabidopsis Proteins | Enzyme Inhibitors - chemistry | Plants, Genetically Modified | Cloning, Molecular | Gene Expression Regulation, Plant | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Cyclin-Dependent Kinases - genetics | Kinesin | Calcium-Binding Proteins - metabolism | Amino Acid Sequence | Arabidopsis - chemistry | Enzyme Inhibitors - metabolism | Cell Cycle Proteins - metabolism | Plant Leaves - cytology | Arabidopsis - metabolism | Cyclin-Dependent Kinase Inhibitor p27 | Arabidopsis - genetics | Muscle Proteins - genetics | Phenotype | Plant Leaves - physiology | Tumor Suppressor Proteins | Calcium-Binding Proteins - genetics | Physiological aspects | Genetic aspects | Research | Growth (Plants) | Arabidopsis | Kip-related protein | KRP gene | Kip1 gene | cyclin-dependent kinase | p27 protein | Index Medicus
Journal Article
Plant Cell, ISSN 1040-4651, 2001, Volume 13, Issue 7, pp. 1653 - 1667
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1083 - 1097
Genetic variation at the chromosome 9p21 risk locus promotes cardiovascular disease; however, it is unclear how or which proteins encoded at this locus... 
ENDOTHELIAL LIPASE | MEDICINE, RESEARCH & EXPERIMENTAL | SEQUENCE VARIANT | CHOLESTEROL EFFLUX | SUSCEPTIBILITY | MUSCLE-CELL APOPTOSIS | CHROMOSOME 9P21 | ABC TRANSPORTERS | CORONARY-HEART-DISEASE | EXPRESSION | MOUSE MODELS | Plaque, Atherosclerotic - genetics | Atherosclerosis - genetics | Coculture Techniques | Humans | Male | Atherosclerosis - enzymology | Plaque, Atherosclerotic - enzymology | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Calreticulin - metabolism | Female | Plaque, Atherosclerotic - pathology | E2F4 Transcription Factor - metabolism | Macrophages - physiology | Atherosclerosis - pathology | Coronary Vessels - pathology | Gene Expression | Myocytes, Smooth Muscle - enzymology | Down-Regulation | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Cells, Cultured | Mice, Knockout | E2F4 Transcription Factor - genetics | Animals | Retinoblastoma Protein - genetics | Carotid Arteries - pathology | Mice | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Quantitative Trait Loci | Necrosis - enzymology | Phagocytosis | Apoptosis | Physiological aspects | Development and progression | Enzyme inhibitors | Genetic variation | Identification and classification | Atherosclerosis | Studies | Heart attacks | Cardiovascular disease | Software | Genomes | Grants | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus | Abridged Index Medicus
Journal Article